Yilmaz, OCabalar, MOzbilgin, S2025-05-102025-05-1019990145-62962-s2.0-0032794441https://hdl.handle.net/20.500.14720/4340Cabalar, Mehmet/0000-0001-9505-0809Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.eninfo:eu-repo/semantics/closedAccessArticle414N/AN/A22222510434375WOS:000081641900007