Bildirici, IshakCetin, AdnanMenges, NurettinAlan, Yusuf2025-05-102025-05-1020180352-513910.2298/JSC170313029B2-s2.0-85053694338https://doi.org/10.2298/JSC170313029Bhttps://hdl.handle.net/20.500.14720/7549Bildirici, Ishak/0000-0001-8590-3070; Cetin, Adnan/0000-0003-4838-1503; Alan, Yusuf/0000-0003-0007-0212; Menges, Nurettin/0000-0002-5990-6275A series of tetrasubstituted pyrazole-3-carboxamides (3a-c) and pyrazole-3-carbonyl thioureides (6a-c) were synthesized and their structures characterized by IR, NMR and elemental analysis. The antibacterial potential against specific Gram-positive and Gram-negative strains and the antifungal activities of all novel compounds were investigated. Structure-activity relationships (SAR) studies and some theoretical parameters (ClogP, CMR, PSA and ESP) of the compounds were performed on these two pyrazole derivatives. Pyrazole-3-carboxylate ester 2 was used for the synthesis of the carboxamide derivatives. The reactions of pyrazole-3-carbonyl isothiocyanate 5 with appropriate chiral amino alcohols were utilized for synthesizing the thioureide derivatives. Both of these types of pyrazole derivatives including a chiral moiety exhibited pronounced antibacterial activities. According to the present in vitro study, some of the promising compounds might be new candidates for a new generation of antibacterial drugs.eninfo:eu-repo/semantics/openAccessBiological ActivityChiral Amino AlcoholsPyrazoleHeterocyclic CompoundsArticle837-8Q4Q3795807WOS:000441529600001