Taskiran, AysegulAcikgoz, EdaOktem, Gulperi2026-04-022026-04-0220260304-419X1879-256110.1016/j.bbcan.2026.1895652-s2.0-105033154007https://hdl.handle.net/123456789/30027https://doi.org/10.1016/j.bbcan.2026.189565A principal challenge in modern biology and biomedical research is the comprehensive elucidation of the molecular and cellular mechanisms that underpin human disease, with the ultimate aim of identifying novel and effective therapeutic targets. Embryogenesis represents a paradigm of tightly regulated biological complexity, orchestrated by elaborate networks of signaling pathways and transcriptional programs. This highly dynamic process, which initially unfolds within a seemingly disordered and heterogeneous microenvironment, is progressively structured through the establishment of intricate molecular equilibriums mediated by a diverse array of regulatory factors. Perturbations of these homeostatic balances at later stages frequently precipitate the emergence of various pathological conditions. Raf kinase inhibitor protein (RKIP) and Yin Yang 1 (YY1) are pleiotropic regulatory molecules implicated in a broad range of fundamental cellular processes, including proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition. Although these factors have conventionally been examined as discrete entities, emerging evidence indicates that RKIP and, YY1 may engage in significant molecular cross-talk that not only influences embryonic development but also contributes to the pathogenesis of diverse diseases, including cancer, autoimmune disorders, and immunological dysfunctions. Focusing on the pivotal developmental process of embryogenesis, this review explores the individual regulatory functions of RKIP and YY1, while emphasizing their potential points of convergence within signaling networks during both physiological development and pathological states.eninfo:eu-repo/semantics/closedAccessYY1Embriyonic DevelopmentCancerImmune ModulationRKIPInflammationArticle