Isik, MesutKurhan, FarukUlkevan, TubaOzdemir, Pinar Guzel2025-05-102025-05-1020220362-56641537-162X10.1097/WNF.00000000000004902-s2.0-85123651377https://doi.org/10.1097/WNF.0000000000000490https://hdl.handle.net/20.500.14720/14327Kurhan, Faruk/0000-0003-3718-0458; Isik, Mesut/0000-0003-1707-7402Background: Vortioxetine is a novel multimodal antidepressant for the treatment of major depressive disorders and is widely used in clinical practice. Vortioxetine has a safe profile. However, there are case reports of other adverse effects in the literature. In this article, a case of amenorrhea due to vortioxetine is presented. Case: The patient is 36 years old, married, female, and is an anesthesiologist. She applied to the psychiatric outpatient clinic with symptoms of major depression. Vortioxetine was initiated at 10 mg/d and then gradually increased to 20 mg/d. She had regular menstruation until now. However, she did not menstruate after taking vortioxetine. The patient used vortioxetine for 3months and never had a period. Pregnancy test and other tests to investigate organic etiology were normal. Twoweeks after discontinuation of vortioxetine, the patient had a menstrual period. Conclusions: Further research is needed on the relationship and possible mechanisms between vortioxetine and amenorrhea.eninfo:eu-repo/semantics/closedAccessVortioxetineAmenorrheaAdverse EffectArticle451Q4Q37835029863WOS:000968226900002