Arslantaş, AliAgirtas, M. Salih2025-05-102025-05-1020172149-21232148-4171https://search.trdizin.gov.tr/en/yayin/detay/271564/study-on-dna-binding-properties-of-nickle-ii-phthalocyanine-compound-with-2-isopropyl-5-methylphenoxy-substituentshttps://hdl.handle.net/20.500.14720/8748I n this study, previously synthesized Ni (II) phthalocyanine compound bearing 2,10,16,24-tetrakis(2-isopropyl-5-methylphenoxy group was chosen for its interaction with calf thymus-DNA. Calf thymus-DNA was used to determine DNA binding properties of Ni (II) phthalocyanine compound. The DNA binding activities of Ni (II) phthalocyanine compound bearing 2-isopropyl-5-methylphenoxy substituent was investigated by using absorption titration, fluorescence emission, cyclic voltammetry, gel elctrophoresis in Tris-HCl buffer at pH 7.0. In addition to above methods, melting point and viscosity experiment were performed to determine the DNA intercation of the compound in Tris-HCl buffer solution. The results showed that Ni (II) phthalocyanine compound binds strongly to calf thymus-DNA via intercalation bindingeninfo:eu-repo/semantics/openAccessBiyolojiKimyaTıbbiBiyokimya Ve Moleküler BiyolojiArticle42N/AN/A9197271564