Mercan, U.Öner, A.C.Öntürk, H.Cengiz, N.Erten, R.Özgökç, F.Özbek, H.2025-05-102025-05-1020081827-86202-s2.0-43549125216https://hdl.handle.net/20.500.14720/18142The aim of this study was to investigate hepatoprotective and anti-inflammatory activities of Artemisia austriaca J. Jacq. essential oil (AA). Artemisia groups were injected AA in doses of 0.05 mL/kg (AA-I), 0.1 mL/kg (AA-II) and 0.2 mL/kg (AA-III) in both inflammatory and hepatotoxicity experiments. The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Artemisia did not have an anti-inflammatory effect matching to that of control group at any doses. It was found that reduction in inflammation was 96.62% with indomethacin, 5.71% with AA-I, 10.54% with AA-II and 31.37% with AA-III. AA-I significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the AA-I and CCl4 groups. The results showed that Artemisia austriaca J. Jacq. had considerable hepatoprotective activity while it did not show an anti-inflammatory activity.eninfo:eu-repo/semantics/closedAccessAnti-Inflammatory ActivityArtemisia Austriaca J. Jacq.Hepatoprotective ActivityRatArticle1N/AN/A131138