Gumus, AysegulOkumus, Veysi2025-05-102025-05-1020181300-052710.3906/kim-1804-182-s2.0-85054924363https://doi.org/10.3906/kim-1804-18https://hdl.handle.net/20.500.14720/7586Gumus, Aysegul/0000-0002-1613-7074; Okumus, Veysi/0000-0002-5505-2700One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b > 3a > 1b and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 mu g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis.eninfo:eu-repo/semantics/openAccessQuinolineQuinoloneTriazoleAntioxidantAntibacterialArticle425Q4Q313441357381672WOS:000451313100013