Yunusoglu, OrucAllahverdiyeva, ShabnamYardim, YavuzSenturk, Zuhre2025-05-102025-05-1020201040-03971521-410910.1002/elan.2019004522-s2.0-85073975991https://doi.org/10.1002/elan.201900452https://hdl.handle.net/20.500.14720/13530Yardim, Yavuz/0000-0002-9587-096X; Senturk, Zuhre/0000-0002-0356-9345; Yunusoglu, Oruc/0000-0003-1075-9574The present work describes the individual, selective and simultaneous quantification of acetaminophen (ACP) and tramadol hydrochloride (TRA) using a modification-free boron-doped diamond (BDD) electrode. Cyclic voltammetric measurements revealed that the profile of the binary mixtures of ACP and TRA were manifested by two irreversible oxidation peaks at about +1.04 V (for ACP) and +1.61 V (for TRA) in Britton-Robinson (BR) buffer pH 3.0. TRA oxidation peak was significantly improved in the presence of anionic surfactant, sodium dodecyl sulfate (SDS), while ACP signal did not change. By employing square-wave stripping mode in BR buffer pH 3.0 containing 8x10(-4) mol L-1 SDS after 30 s accumulation under open-circuit voltage, the BDD electrode could be used for quantification of ACP and TRA simultaneously in the ranges 1.0-70 mu g mL(-1) (6.6x10(-6)-4.6x10(-4) mol L-1) and 1.0-70 mu g mL(-1) (3.3x10(-6)-2.3x10(-4) mol L-1), with detection limits of 0.11 mu g mL(-1) (7.3x10(-7) mol L-1) and 0.13 mu g mL(-1) (4.3x10(-7) mol L-1), respectively. The practical applicability of the proposed approach was tested for the individual and simultaneous quantification of ACP and/or TRA in the pharmaceutical dosage forms.eninfo:eu-repo/semantics/closedAccessAcetaminophenTramadolBoron-Doped Diamond ElectrodeSodium Dodecyl SulfateSquare-Wave Adsorptive Stripping VoltammetryPharmaceutical FormulationArticle322Q2Q2429436WOS:000486818500001