Browsing by Author "Çaksen, H"

Now showing 1 - 20 of 110

Acute Amitriptyline Intoxication
(Sage Publications Ltd, 2006) Çaksen, H; Akbayram, S; Odabas, D; Özbek, H; Erol, M; Akgün, C; Yilmaz, C
The tricyclic antidepressant agents, particularly amitriptyline and dothiepin, are recognized for their potentially lethal cardiovascular and neurological effects in poisoned patients. In this article, the clinical and laboratory findings of 44 children with amitriptyline intoxication are reviewed. Our purpose was to investigate amitriptyline intoxication in childhood. Of 44 patients, 21 ( 47.7%) were boys, 23 ( 52.3%) were girls, and the ages ranged from 12 months to 14 years ( mean +/- SD; 4.09 +/- 2.9 years). All children except one who took an overdose of amitriptyline to decrease his pain accidentally ingested an overdose of amitriptyline. The amount of amitriptyline ingested was between 2 mg/kg and 97.5 mg/kg (mean +/- SD; 13.6 +/- 17.7 mg/kg per dose) (the drug dosage was not known in 13 children). The most commonly observed clinical and laboratory findings were lethargy, tachycardia, convulsion, hyperglycemia and leukocytosis. In all patients except for two children who died the abnormal clinical and laboratory findings returned to normal within a few days after admission and they were discharged from the hospital in good health within the fourth day of admission. One of the children ingested 97.5 mg/kg amitriptyline and probably died due to status epilepticus and another child who died ingested 36 mg/kg amitriptyline and died due to cardiopulmonary arrest. In conclusion, our findings showed that initial symptoms and signs of acute amitriptyline intoxication appeared severe, but they disappeared with only supportive care required in most children except for cases that ingested high doses of drug within a few days. In contrast to adults, we infrequently noted respiratory insufficiency, arrhythmia and hypotension in children with acute amitriptyline intoxication.
An Adrenal Cyst in a Newborn
(Springer-verlag, 2003) Içagasioglu, D; Çaksen, H; Yildiz, E; Koçyigit, C; Cevit, Ö
Adrenal cysts (AC) are rare, particularly in the newborn period. Almost all ACs in newborns were diagnosed on exploratory laparotomy or at autopsy. We report a newborn with an AC that was diagnosed after an exploratory laparotomy due to its rare presentation. This case shows that ACs should be considered in the differential diagnosis of an abdominal mass in the newborn period.
Anal Protrusion of Ventriculo-Peritoneal Shunt Catheter in an Infant
(Elsevier Science Bv, 2003) Çaksen, H; Kiymaz, N; Odabas, D; Tuncer, O; Atas, B
An Analysis of Seven Infants With Brachmann-De Lange Syndrome, of Whom Two Identical Twin Sisters
(Medecine Et Hygiene, 2001) Çaksen, H; Kurtoglu, S; Cesur, Y; Öztürk, A
An analysis of seven Infants with Brachmann-de Lange syndrome, of whom two identical twin sisters: Brachmann-de Lange syndrome (BDLS) is characterized by typical facial features, intrauterine growth retardation, short stature, microbrachycephaly, hirsutism and limb anomalies. Here, we reviewed the findings of seven infants with BDLS, of whom two were identical twin sisters of normal parents. All of the infants' parents were normal, and no consanguinity between the parents was noted although the ratio of consanguineous marriages is very high (21.1%) in Turkey. It is well known that most cases of BDLS are sporadic, some cases of this disorder are inherited in an autosomal dominant trait. Our findings suggested that familial cases of BDLS were infrequent, and vast majority of cases appeared to be sporadic and the occurrence of the syndrome in the identical twin sisters of normal parents was also thought a heterogeneity in this condition, overlapping with other conditions and syndromes as mentioned by Fryns et al. (6).
Anhidrotic Ectodermal Dysplasia in a Child With a Fever of Unknown Origin
(Japanese dermatolgical Assoc, 2001) Üner, A; Çaksen, H; Odabas, D
Anti-Oxidant Activity in Measles
(Maney Publishing, 2005) Cemek, M; Bayiroglu, F; Çaksen, H; Cemek, F; Dede, S
Background: Measles leads to serious complications, especially in developing countries. Aim: Our aim was to evaluate the effect of oxidative stress on the enzymatic and non-enzymatic anti-oxidant status in children with measles. Methods: Levels of superoxide dismutase, glutathione peroxidase, catalase, ceruloplasmin, albumin, total bilirubin and uric acid were studied in 17 children with measles and 29 healthy controls. Results and conclusions: There was a statistically significant difference between the groups for all parameters. All of the anti-oxidant activities except for albumin level were increased in the study group. Both enzymatic and nonenzymatic anti-oxidant defence systems were affected in measles.
An Association of Foamy Cells in Liver and Hemolytic Anemia in a Fatal Newborn Infant
(Elsevier Science inc, 2003) Çaksen, H; Kurtoglu, S
Asymmetric Crying Facies and Congenital Hypothyroidism
(Freund Publishing House Ltd, 2001) Kurtoglu, S; Çaksen, H; Per, H; Narin, N; Üzum, K
A congenital asymmetric crying facies (ACF) is caused by congenital hypoplasia or agenesis of the depressor anguli oris muscle. Associations of this facial defect with major congenital anomalies have been reported, most commonly in the cardiovascular system and less frequently involving the genitourinary, musculoskeletal, cervicofacial, respiratory, and rarely, the endocrine system. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac defects. Two newborn infants who had ACF associated with congenital heart defect and congenital hypothyroidism are described. To the best of our knowledge the association of ACF and congenital hypothyroidism has not previously been published.
Auditory Brainstem Potentials in Children With Protein Energy Malnutrition
(Elsevier Ireland Ltd, 2005) Odabas, D; Çaksen, H; Sar, S; Tombul, T; Kisli, M; Tuncer, J; Yilmaz, C
Objective: In this study, auditory brainstern potentials (ABPs) were studied in children with protein energy malnutrition (PEM) to determine the effects of PEM on the developing brain in children. Methods: A total of 31 children, aged 3-36 months with moderate/severe PEM and 25 healthy children, aged 3-48 months were included in the study. Nutritional status of the children was assessed by the Gomez classification. Recordings of ABPs were performed by using Nihon Kohden Neuropack 2 device. Results: Of 31 children, 22 (71%) had severe malnutrition, 9 (29%) had moderate malnutrition. Additionally, 8 (26%) and 9 (29%) children had iron deficiency anemia and hypoalbuminemi, respectively. There were significant differences in the mean latencies of the waves I-V on the right and left ears and in the mean interpeak latencies (IPLs) of the waves III-V and I-V on the right ear between the study and control groups (P < 0.05). The mean IPLs of I-V on the left side were found to be longer in the moderate PEM group than those of severe PEM group (P < 0.05). There was not any difference between the groups of PEM with low serum albumin and PEM with normal serum albumin. While the mean IPLs of I-III on the right side were found longer in the cases of PEM without iron deficiency anemia, the mean latency of wave I on the left side, and the mean IPLs of III-Von the right side were longer in the children with PEM plus iron deficiency anemia (P < 0.05). Conclusions: Our findings showed that children with moderate/severe PEM had ABPs abnormalities in different degrees, which reflect defects in myelination of auditory brainstem pathways in children with moderate/severe PEM. However, we found contradictory results between abnormalities in ABPs and degree of malnutrition and iron deficiency anemia. We think that more extensive studies should be performed to determine whether or not there was a relationship between these parameters. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Aural Myiasis in Children and Literature Review
(Tohoku Univ Medical Press, 2005) Yuca, K; Çaksen, H; Sakin, YF; Yuca, SA; Kiris, M; Yilmaz, H; Çankaya, H
Myiasis is a disease caused by fly larvae. The term "myiasis" is derived from the Greek word "myia" meaning fly. Aural myiasis is a rare clinical state and occurs frequently in children. In this article, six children with aural myiasis, caused by the fly larvae, are reported because of unusual presentation. All of the children with aural myiasis were associated with chronic otitis media. In the treatment, a combination of suctioning and alligator forceps was used to remove maggots under the light microscopic field. Additionally, antibiotics were used in all children. Thus, aural myiasis is successfully treated by direct extraction of larvae and application of preventative methods. - myiasis; fly larvae; chronic otitis media; maggots; children (c) 2005 Tohoku University Medical Press.
Bilateral Brachial Plexopathy Complicating Henoch-Schonlein Purpura
(Elsevier Science Bv, 2006) Yilmaz, C; Çaksen, H; Arslan, S; Anlar, Ö; Atas, B; Güven, AS; Odabas, D
An 11-year-old boy presented with convulsion, fever, rash, abdominal pain, swelling on the eyelids, elbow and wrists, oliguria and hematuria. Based on the abnormal findings the patient was diagnosed with Henoch-Schonlein purpura. On the 3rd day of admission, neurological examination showed ataxic gait, loss of deep tendon reflexes, and decreased (4/5) of muscle strength on all extremities. Additionally, bilateral loss of touch, pain and temperature sensation in a glove, from the elbows to distal region (on C5-T1 level) was diagnosed. Cerebrospinal fluid examination and cranial magnetic resonance imaging (MRI) were normal. The patient was discharged with oral prednisolone on the 7th day of admission. One week after discharging from the hospital, he was re-admitted with vertigo and seizures. He was in coma. MRI of cranial, cervical and cervical plexus were normal. Electromyography showed severe bilateral brachial plexopathy. Prednisolone and intravenous immunglobulin (IVIG) therapy were given without significant improvement. He was discharged from the hospital on the 17th day of admission. On the second month of follow-up, a second cure of IVIG was given because of no clinical improvement. Now, he is on the 4th month of follow-up, unfortunately, no improvement was noted on his muscle strength and sensorial abnormalities on the upper extremities. (c) 2006 Elsevier B.V. All rights reserved.
Bilateral Galactocele in a Male Infant
(Freund Publishing House Ltd, 2001) Cesur, Y; Çaksen, H; Demirtas, I; Kösem, M; Üner, A; Özer, R
A galactocele is a rare benign breast lesion usually occurring in females during or following lactation. These lesions are a rare cause of breast enlargement in infants and children. In this article we present a 10 month-old boy who was admitted with a two-month history of bilateral progressive breast enlargement, and diagnosed as having galactocele. Our purpose was to emphasize the importance of galactocele as a benign condition in the differential diagnosis of gynecomastia in childhood.
A Boy With Organophosphate Poisoning Mimicking a Foreign Body Aspiration
(Elsevier Science inc, 2005) Çaksen, H; Demirtas, M; Tuncer, O; Odabas, D; Ceylan, N; Kati, I; Köseoglu, B
Cardiac Findings in Childhood Staphylococcal Sepsis
(Japan Heart Journal, Second dept of internal Med, 2002) Çaksen, H; Üzüm, K; Yüksel, S; Basrîüstünbas, H; Öztürk, MK; Narin, N
The clinical and laboratory findings of eight (20%) cases of cardiac involvement of 39 patients with sepsis caused by S. aureus (Staphylococcus aureus) were reviewed retrospectively. Our purpose was to emphasize the importance of the cardiac findings in patients with sepsis caused by S. aureus in childhood. The ages of the patients ranged from 6 to 14 years. All patients had pericardial effusion which was confirmed by echocardiographic (ECHO) examination in all cases except the one in whom ECHO examination could not be performed because he died 2.5 days after admission to the hospital. This patient also had myocarditis and heart failure. Aside from these, mitral insufficiency was diagnosed in the other patient; it was accepted as a sequela of rheumatic fever acquired previously. Open pericardial drainage was conducted Successfully in the case who had a progression to cardiac tamponade. In the other patients pericardial effusion completely resolved with Supportive and antibiotic therapy one to two weeks. Two of eight patients died from sepsis and septic shock; the mortality rate was 25%. Our findings show that cardiac involvement was fairly high (20%) in S. aureus sepsis in childhood. Therefore, it is suggested that children with S. aureus sepsis Should be carefully monitored for cardiac involvement.
A Case of Acquired Gastric Outlet Obstruction Diagnosed at 16 Years of Age
(Springer, 2004) Abuhandan, M; Çaksen, H; Eskiçubuk, S
A 16-year-old boy was admitted with an 8-year history of abdominal pain, vomiting, and growth retardation. There was no history of peptic ulcer or caustic ingestion. He was severely cachexic, and barium meal showed a dilated stomach with delayed gastric emptying time and no contrast in the duodenum afterward. Exploratory laparotomy demonstrated a grossly dilated stomach with a smooth wall and a stenotic ring at the pylorus but without any muscular hypertrophy. There was no extrinsic compression of the pylorus or any scarring near it. Heineke-Mikulicz' pyloroplasty was performed. Histopathological examination of the pylorus showed normal cellular pattern without any neoplastic or inflammatory cells. The patient improved postoperatively and gained 8 kg in the first month following the operation.
A Case of Adams-Oliver Syndrome Associated With Acrania, Microcephaly, Hemiplegia, Epilepsy, and Mental Retardation
(Acta Medica Belgica, 2000) Çaksen, H; Kurtoglu, S
Adams-Oliver syndrome (AOS) is a rare congenital disorder, characterized by aplasia cutis congenita (ACC) of the scalp and variable degrees of terminal transverse limb defects. In this article, a newborn infant diagnosed as AOS for a large scalp defect, acrania, and finger malformations is presented. The patient was hospitalized and the scalp defect was successfully repaired with several surgical operations. During the hospitalization septicemia. meningitis, and convulsions developed, but they were successfully treated with appropriate antibiotics, antifungal. and anticonvulsive agents. He was discharged five months after admission to the hospital. Now, he is 3 years old, and has microcephaly, moderate mental retardation, left spastic hemiplegia, and epilepsy.
A Case of Allgrove (Triple A) Syndrome Associated With Renal Ectopia
(Medecine Et Hygiene, 2002) Çaksen, H; Cesur, Y; Kirimi, E; Üner, A; Arslan, S; Çelebi, V; Odabas, D
Allgrove syndrome (triple A syndrome) is an autosomal recessive disorder characterized by adrenocorticotropin hormone-resistant adrenal insufficiency, achalasia and alacrima. Aside from the classic features of the syndrome, several abnormalities including mainly neurological abnormalities have been reported in the syndrome. Herein, we presented a case of Allgrove syndrome associated with left renal ectopia. To the best of our knowledge renal abnormality in Allgrove syndrome has not been reported in the literature until now. We think that ectopic kidney diagnosed in our patient is coincidental because the incidence of renal ectopia is high, approximately I in 900 in population.
A Case of Chronic Renal Failure Misdiagnosed as Status Asthmaticus
(Elsevier Science inc, 2002) Çaksen, H; Odabas, D; Arslan, S
A Case of Enteric Fever Presenting With Insidious Neuropsychiatric Manifestations
(Elsevier Science inc, 2004) Çaksen, H; Akbayram, S; Odabas, D; Anlar, Ö
A Case of Immune Thrombocytopenic Purpura Presenting With Recurrent Intracranial Hemorrhage
(Wiley, 2005) Bay, A; Öner, AF; Etlik, Ö; Çaksen, H