Browsing by Author "Çalka, Ö"

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Anti-Inflammatory Effects of Tretinoin (all-Trans Acid) 0.1% and Adapalene 0.1% in Rats
(Wiley, 2005) Akdeniz, N; Çalka, Ö; Özbek, H; Metin, A
In this study, the anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% cream and adapalene 0.1% gel were compared in rats to determine whether there was a difference between these agents. Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher than adapalene and controls (P < 0.05). Adapalene was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity. We conclude that tretinoin has a higher anti-inflammatory activity than adapalene and thus should be preferred for the treatment of inflammatory lesions.
A Case of Disseminated and Recurrent Infundibulofolliculitis Responsive To Treatment With Systemic Isotretinoin
(Wiley, 2002) Çalka, Ö; Metin, A; Özen, S
We report a 16-year-old Turkish patient who developed disseminated and recurrent infundibulofolliculitis (DRIF) and responded well to systemic isotretinoin therapy after three months.
A Destructive Ulcer
(Blackwell Publishing, 2005) Akdeniz, N; Çalka, Ö; Metin, A; Yuca, K; Özen, S
Effect of Cyproheptadine on Serum Leptin Levels
(Springer, 2005) Çalka, Ö; Metin, A; Dülger, H; Erkoç, R
Leptin is a 167 amino acid protein encoded by the obesity gene that is synthesized in adipose tissue and interacts with receptors in the hypothalamus linked to the regulation of appetite and metabolism. It is known to suppress appetite and increase energy expenditure. Cyproheptadine is a piperidine antihistamine that increases appetite through its antiserotonergic effect on 5-HT2 receptors in the brain. Although both leptin and cyproheptacline are effective in controlling appetite, their interaction has not been addressed in clinical studies. This study evaluated serum leptin concentrations in patients who received cyproheptadine to treat a variety of disorders. Sixteen patients aged 7 to 71 years (mean, 26.25 years) were given cyproheptacline 2 to 6 mg/day for a minimum of 7 days. Body weight was measured and blood samples were obtained at baseline and after 1 week of treatment. Serum leptin levels were determined by leptin radioimmunoassay. The mean body weight at baseline (52.59 kg) did not differ significantly from that at 1 week after treatment (52.84 kg; P >.05), but the mean leptin level after 1 week of treatment with cyproheptacline (3.14 ng/mL) was 14.2% higher than that at baseline (2.75 ng/mL; P <.05). This increase may suggest that both leptin and cyproheptacline may affect appetite via similar receptors and that cyproheptacline does not impair leptin activity through these receptors. Further study will be necessary to clarify this relationship.
Lichen Planopilaris Coexisting With Erythema Dyschromicum Perstans
(Blackwell Science Ltd, 2001) Metin, A; Çalka, Ö; Ugras, S
Phototoxic Dermatitis Due To Chenopodium Album in a Mother and Son
(Wiley, 2005) Çalka, Ö; Akdeniz, N; Metin, A; Behçet, L
Phytodermatitis From Ceratocephalus Falcatus
(Blackwell Publishing, 2005) Metin, A; Çalka, Ö; Akdeniz, N; Behçet, L
Ceratocephalus falcatus (L.) Pers. (Ranunculaceae) is a wild plant. It grows abundantly in the Van province. The species of Ceratocephalus genus possess irritant properties from the presence of an innocuous glycoside, ranunculin. Here, we document 3 patients who were admitted to our clinic in different times from different districts with a common complaint of a large irritant contact dermatitis, resembling second-degree burn injury after application of a plant poultice. The plant specimens in all patients were identified as C. falcatus and it was assessed worthwhile to report.
Phytodermatitis From Ranunculus Damascenus
(Munksgaard int Publ Ltd, 2001) Metin, A; Çalka, Ö; Behçet, L; Yildirim, E
Primary Varicella Infection Associated With Stevens-Johnson Syndrome in a Turkish Child
(Japanese dermatolgical Assoc, 2005) Bay, A; Akdeniz, N; Çalka, Ö; Kösem, M; Öner, AF; Dogan, M
Stevens-Johnson syndrome (SJS) is defined as a severe erythema-multiforme-like eruption of the skin and lesions of the oral, genital and anal mucosa and hemorrhagic crusting on the lips; it is associated with fever, headache, and arthralgia. The disease is a part of a continuum of immunologically mediated mucocutaneous diseases at various grades of severity. SJS is often induced by drugs, but the pathophysiologic mechanism is completely unknown. Patients and their first degree-relatives may have genetic defects in their metabolic pathways that lead to the accumulation of toxic metabolites. However, viral infections are known triggers of this skin disorder. Varicella zoster virus has been only very rarely reported as an etiological agent in SJS, despite its high incidence as a pathogen in childhood. In this study, we report a case of primary varicella infection associated with SJS because of its rare presentation. To the best of our knowledge, our case is the youngest child in the literature.
Report of a Turkish Child With Sjogren-Larsson Syndrome Associated With Peripheral Nerve Involvement
(Japanese dermatolgical Assoc, 2003) Akdeniz, N; Çalka, Ö; Anlar, Ö; Akbayram, S; Çaksen, H; Metin, A; Çinal, A
Sjogren-Larsson syndrome is a rare hereditary neurocutaneous disorder characterized by ichthyosis, spastic di- or tetra-plegia, and mild to moderate mental retardation. In this article, we present a nine-year-old girl with the classical features of the syndrome associated with peripheral nerve involvement because of its rare presentation. To the best of our knowledge, only three cases of Sjogren-Larsson syndrome with peripheral nerve involvement have been previously reported in the literature. We assume that Sjogren-Larsson syndrome involves extensive disorders of the ectodermal tissues, including the peripheral nerves as well as the skin and the central nervous system.
Tinea Capitis in Van, Turkey
(Wiley, 2002) Metin, A; Subasi, S; Bozkurt, H; Çalka, Ö
Forty patients with an average age of 6.5 +/- 3.2 years (28 male 12 female) who applied to the YYU Medical Faculty Dermatology Department outpatient clinic were investigated. Tinea capitis profunda was determined as the most frequent clinical type. The isolated dermatophytic flora of the patients consisted of Trichophyton verrucosum (43%), T. violaceum (30%), T. rubrum (23%) and T. mentagrophytes (3%). The patients with tinea capitis profunda were mostly from rural areas.
A Verrucous Swelling in a Child
(Blackwell Publishing, 2006) Akdeniz, N; Çalka, Ö; Metin, A; Günes Bilgili, S; Kösem, M