Browsing by Author "Çetin, O."

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Cervical Conization and the Risk of Preterm Birth: a Population-Based Multicentric Trial of Turkish Cohort
(Journal of Clinical and Diagnostic Research, 2017) Zebitay, A.G.; Güngör, E.S.; Ilhan, G.; Çetin, O.; Dane, C.; Furtuna, C.; Tuna, M.
Introduction: Cold Knife Conization (CKC) is one of the most effective methods for the treatment of Cervical Intraepithelial Neoplasia (CIN). Some studies showed a relation between preterm birth and the treatment of CIN; on the other hand, other studies do not show such a relationship. Aim: The present study was conducted with the aim to investigate the pregnancy outcomes of Turkish women regarding demographic characteristics, obstetric history, removed tissue, and residual cervical length after CKC and to determine the effect of removed cervical tissue volume and height on preterm birth. Materials and Methods: This study was a population-based, multicenter trial that was conducted on singleton pregnancies between January 2007 and December 2013. The control group comprised of 38,892 patients who gave birth during this period. On the other hand, patients who conceived after CKC during this period were invited to the hospital and included in the case group (n=20). The course of pregnancy following CKC was studied. Preterm birth rates, risk factors for preterm birth, conisation age, cervical smear and colposcopic biopsy results and the volume and height of the removed cervical tissue of those patients were evaluated. Results: There was no statistically significant difference in preterm birth rates between the case and the control groups. None of our cases had any identified preterm birth risk factor except for one case. The average height of removed cervical tissue was 12.6±5.4 mm and the average length of the residual cervix after birth was 28.7±4.3 mm. Conclusion: Removal of cervical tissue of 12.6±5.4 mm in height and 2.35±2.27 cm³ in volume will not increase the risk of preterm birth of women who do not have any other preterm birth risk factors. If there is no other preterm birth risk factors, term birth is most probably possible after conisation. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Effects of Different Progestins in Oral Contraceptives on Sexual Function and Well-Being of Women
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Çetin, O.; Keskin, S.; Verit, F.F.; Yücel, O.
To compare the effects of different progestins in combined oral contraceptives (COC) on sexual functions and well-being of women. In this prospective and observational study, 52 participants used drosperinone, 48 participants used gestodene, 55 participants used levonorgestrele and 60 participants used non- hormonal contraception. All participants completed the Female Sexual Function Index (FSFI) and Beck Depression Inventory (BDI) at baseline and after six cycles of treatment. There was a statistically significant improvement between FSFI scores at baseline and after six cycles of treatment compared with each other. There was no significant difference between FSFI scores compared with each other. In the hormonal contraception group, there was a statistically significant increase between BDI scores at baseline and after six cycles of treatment. In each hormonal contraception subgroup, there was no significant difference between BDI scores. These data show that COC pills make positive effects on female sexuality. Androgenic or antiandrogenic progestins have similar improvements on female sexual function. In addition, COC pills have negative impacts on depression. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Maternal Thyroid Autoimmune Status in Gestational Trophoblastic Disorders
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Karaman, E.; Çetin, O.; Çim, N.; Kolusarı, A.; Güler, S.; Yıldızhan, R.; Şahin, H.G.
To investigate the maternal autoimmune status of patients with molar pregnancies. The study was conducted at Yuzuncu Yil University, Department of Obstetrics and Gynecology between January 2012 and June 2016. The medical records of patients who were diagnosed and followed for complete and partial molar pregnancies were reviewed retrospectively. The data of patients who were studied for maternal thyroid auto-antibodies including AntiThyroid peroxidase (TPO) and Anti-Tyroglobulin (Tg) were included in the study. The mean maternal age of complete molar pregnancies were significantly higher than partial molar pregnancies (p=0.010). There were no significant differences between two groups in terms of beta-hCG, TSH, and free T4 (p=0.815, p=0.204, and p=0.072, respectively). None of the patients were anti-TPO positive in the study. There was no significant difference in anti-thyroglobulin positivity between the two groups (p=0.950). Maternal thyroid autoantibody status did not show any difference between the partial and complete molar pregnancies. Thyroid dysfunction seen in molar pregnancies seems to be due to the stimulation of follicular cell receptors with hCG rather than auto-antibodies against thyroid gland. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Maternal Serum Ischemia Modified Albumin Level Does Not Change in the Presence of Intrauterine Growth Restriction
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Çetin, O.; Karaman, E.; Tolunay, H.E.; Boza, B.; Cim, N.; Alisik, M.; Şahin, H.G.
Maternal vascular hypoperfusion is the most common cause of fetal growth restrict ion. Maternal oxidative status features are identifiable on placental pathology, and antepartum diagnostic methods are rapidly evolving. The current study was constructed to determine the maternal oxidative status by measuring serum ischemia modified album in (IMA) levels in pregnancies complicated with idiopathic intrauterine growth restriction (IUGR). The current study was designed as a descriptive and cohort trial. A total of 87 pregnant women; 45 healthy controls and 42 pregnancies complicated with idiopathic IUGR were included to the study population. Maternal serum IMA concentration was measured prior to the administration of any medication. The perinatal outcomes of patie nts were also recorded. Maternal serum IMA concentration in pregnancies complicated by idiopathic IUGR was higher than in healthy controls. There was no significant difference between the groups (0.54±0.04 versus 0.55±0.06 ABSU, p: 0.314). IUGR is a significant pregnancy complication. Elevated oxidative stress which leads to an ischemic microenvironment is associated with IUGR. Maternal serum IMA which is a possible marker for oxidative stress is not increase in pregnancies complicated with idiopathic IUGR. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Relationships Between Somatosensory Amplification, Health Anxiety and Low Back Pain Among Pregnant Women
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Yıldırım, A.; Boysan, M.; Karaman, E.; Çetin, O.; Şahin, H.G.
Introduction: A great proportion of pregnant women experience low back pain during pregnancy. The aim of this study was to uncover potential psychological mechanisms underlying pregnancy-related back pain. Method: Fifty two women with low back pain and forty seven women without low back pain were volunteered to participate in the study. A battery set containing the Health Anxiety Inventory (HAI), Hospital Anxiety and Depression Scale (HADS), Somatosensory Amplification Scale (SSAS), and Visual Analog Scale (VAS) was completed by all participants. Group comparisons were conducted using logistic regression analysis. Relationships of psychological symptoms with pain as measured by the VAS were assessed using regression analysis. Results: Regression models showed that somatosensory amplification satisfactorily explained the group difference between pregnant women with and without low back pain. A tendency to anomalous somatic sensation was associated with the individual differences on scores of the VAS. Conclusion: We concluded that pregnant women high in somatosensory amplification were at greater risk of development of low back pain during pregnancy. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All Rights Reserved.