Browsing by Author "Çetin, S."

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The Effect of Body Mass Index on the Outcomes of Open Simple Prostatectomy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Bulut, E.C.; Ertaş, K.; Koparal, M.Y.; Çetin, S.
Simple prostatectomy remains the gold standard treatment for patients with severe lower urinary tract symptoms (LUTS) and patients with enlarged prostate. Obesity, defined as a body mass index over 30kg/m2 by the World Health Organization (WHO), is associated with some perioperative complications. This study aims to investigate the effects of obesity on the outcomes of open simple prostatectomy. The study includes 72 patients that underwent open simple prostatectomy. We compared the treatment outcomes of 49 patients with a body mass index (BMI)<30kg/m2 and 16 patients with a BMI>30kg/m2. We compared t he two groups in terms of change in International Prostate Symptom Score (IPSS), change in uroflowmetry maximum flow rate (Qmax), operation time, intraoperative blood loss, transfusion requirements. The median of change in IPSS scores was 16(11-30) for the group where BMI>30kg/m2 and 15.5(10-20) for the group where BMI<30kg/m2. This difference was not statistically significant (p=0.383). The mean duration of operation was 90.61±17.45 minutes for patients with BMI<30kg/m2 and 121.87±18.78 minutes for patient s with a BMI>30kg/m2. The difference between the two groups was statistically significant (p<0.001). The median of blood loss was 450(200-700) cc for the BMI<30kg/m2 group and 725 (550-850) cc for the BMI>30kg/m2 group, and this difference was statistically significant (p<0.001). However, the blood transfusion requirements of the two groups were statistically similar (p=0.885). Open simple prostatectomy is very important technic in the treatment of BPH patients with enlarged prostates. Despite obesity is associated with a prolonged operation and increased transfusion rates in open simple prostatectomy, it can still be considered a safe treatment method. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effect of Thymoquinone Treatment on Total Oxidant and Total Antioxidant Level in Experimental Diabetic Rats
(Ataturk Universitesi, 2018) Usta, A.; Dede, S.; Çetin, S.
In this study, the effects of thymoquinone implementation to total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were investigated in liver and kidney tissues of diabetic rats induced with STZ. The 24 male Wistar-Albino rats, weighing between 200-250 g were used as material. Rats were divided into four groups, each consisting of six rats; control (C), thymoquinone (TQ), diabetes (D) and diabetes+ thymoquinone (DT) groups. To induce diabetes, a single dose of 45mg/kg streptozotocin (STZ) were administered intraperitoneally (ip) to the rats in groups D and DT. TQ was administered to the rats in DT and TQ groups as 30 mg/kg/21 days by oral gavage. The values of TAS and TOS were measured in liver and kidney tissues at the end of the study. OSI was calculated according to TAS and TOS levels. TAS value in liver tissue was found to be the lowest in the diabetes group (P≤0.05). It was noticed that there was no difference between K and TQ groups with DT group. No difference was detected among groups in terms of liver TOS. It was determined that the OSI in the liver increased in all groups compared to the control (P≤0.05), the highest value was determined in group D, it approached to the control by partially decrease after the application of TQ. While TAS and TOS levels in kidney tissue were found to be the highest in the TQ group and the lowest in the diabetic group (P≤0.05), there was no difference between the other groups. There was no significant difference among the groups in the kidney OSI. As a result, it was determined that TOS, TAS values in liver and kidney tissues of experimental diabetic rats were affected from the TQ application and the OSI value in the liver of the STZ treated groups approached that of the control group, after TQ application. © 2016 Ataturk Universitesi. All rights reserved.
The Effect of Vitamin C and Vitamin E Administration for Treatment and Protection on Serum Vitamin Levels in Rats With Experimentally Fluorosis Created
(Ataturk Universitesi, 2021) Öner, A.C.; Çetin, S.; Yörük, I.H.; Dede, S.
This study aimed to determine the vitamins A-D and E levels in rats with experimental fluorosis and in whom vitamins, C and E were administered for prevention and treatment. One-month-old Wistar-Albino rats were used as material in the study. Nine groups of 8 animals each were studied. Sodium fluoride (NaF) solutions (150 mg/kg) prepared in drinking water were administered ad-libitum during the study. Vitamin C (100 mg/kg), Vitamin E (300 mg/kg) and Vitamin C + Vitamin E (100 mg/kg + 300 mg/kg) were administered to the protection group with water containing 150 ppm NaF for 16 weeks/day. Water containing 150 ppm NaF was given ad-libitum for 16 weeks in the treatment group, and then Vitamin C (100 mg/kg), Vitamin E (300 mg/kg) and Vitamin C + Vitamin E (100 mg/kg + 300 mg/kg) were administered along with normal drinking water for 4 weeks. At the end of sixteen weeks, blood samples were taken from the rats and their serums were removed. Serum Retinol, α-Tocopherol, Vitamin D3 levels were determined by HPLC. In the fluorosis group, it was found that there was no change in serum vitamin A and vitamin D levels with the application of vitamins C and E for treatment and protection, but a decrease in vitamin E level. As a result, it was concluded that the administration of vitamin E is effective in both the prevention and treatment of fluorosis cases. © 2021 Ataturk Universitesi. All rights reserved.
Serum Protein Fraction Profile in Sheep Infected With Sarcoptes Ovis
(Ataturk Universitesi, 2020) Çetin, S.; Usta, A.; Ekici, P.; Dede, S.; Yüksek, V.
Scabies is an ectoparasitic infestation that is rapidly transmitted to sheep of any age. The present study was conducted to identify the significance of serum protein fractions in the diagnosis and treatment of animals infected by Sarcoptes ovis. The study group included 1-4 years old 18 Akkaraman sheeps with excessive itching and molting and infected with natural Sarcoptes ovis scabies and the control group included 1-4 years old 18 healthy sheeps, a total of 36 sheeps were included in the present study. Serum protein fractions were determined with the cellulose-acetate electrophoresis method in collected blood samples. There were no significant differences between total protein and α-2 globulin serum protein concentrations in the study and control groups. Although α-1, β-globulin and albumin concentrations were statistically higher in the patient group, gamma globulin levels decreased in the patient group (P<0.05). While the percentage (%) g protein did not differ based on α-2 globulin when compared to control, α-1, beta globulin, albumin and A/G ratio statistically increased in the patient group when compared to the control (P<0.05). There was a significant decrease in gamma globulins in the patient group when compared to the control (P<0.01). It was concluded that monitoring the serum protein parameters might be significant in the follow-up and treatment of scabies in sheep. © 2020 Ataturk Universitesi. All rights reserved.