Browsing by Author "Çim, N."

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The Effect of Super-Oxidized Water on the Tissues of Uterus and Ovary: an Experimental Rat Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Aras, A.; Karaman, E.; Çim, N.; Yıldırım, S.; Kızıltan, R.; Yılmaz, Ö.
Super-oxidized solutions are known to be potent disinfectants for external surfaces and also for wound care. There are limited data about the use of superoxidized water in the intraperitoneal organs. The aim of the present study was to evalaute its effect on the uterus and ovary when applied via intraperitoneal infusion in a rat model. Thirty Wistar-Albino rats weighing 250-300 g were randomly divided into three groups (10 rats/group). Group1(control group) rats received single dose of 10 mg/kg saline solution intraperitoneally. Group 2(single dose group) rats received single dose of 10 mg/kg pH-neutral SOW intraperitoneally. Group 3(multiple doses group) rats received multiple doses of 10 mg/kg pH-neutral SOW intraperitoneall at first, third and fifth days. All animals were sacrificed at one week after infusion. The macro- and microscopic histopathological examinations were performed for each rat. All rats remained healthy follow up of one week. The macroscopic examinations of the three groups showed no significant differences. No toxicity findings were found in three groups. The microscopic examinations revealed active endometial glandular structures in uterus and functional follicules at different stages of maturation in ovary. There were no significant differences with regards to the microscopic findings between three groups. Intraperitoneal infusion of pH-neutral SOW does not result in any significant toxicity and complications on the tissues of uterus and ovary. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Evaluation of Maternal Thyroid Autoimmune Status in Gestational Trophoblastic Disorders
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Karaman, E.; Çetin, O.; Çim, N.; Kolusarı, A.; Güler, S.; Yıldızhan, R.; Şahin, H.G.
To investigate the maternal autoimmune status of patients with molar pregnancies. The study was conducted at Yuzuncu Yil University, Department of Obstetrics and Gynecology between January 2012 and June 2016. The medical records of patients who were diagnosed and followed for complete and partial molar pregnancies were reviewed retrospectively. The data of patients who were studied for maternal thyroid auto-antibodies including AntiThyroid peroxidase (TPO) and Anti-Tyroglobulin (Tg) were included in the study. The mean maternal age of complete molar pregnancies were significantly higher than partial molar pregnancies (p=0.010). There were no significant differences between two groups in terms of beta-hCG, TSH, and free T4 (p=0.815, p=0.204, and p=0.072, respectively). None of the patients were anti-TPO positive in the study. There was no significant difference in anti-thyroglobulin positivity between the two groups (p=0.950). Maternal thyroid autoantibody status did not show any difference between the partial and complete molar pregnancies. Thyroid dysfunction seen in molar pregnancies seems to be due to the stimulation of follicular cell receptors with hCG rather than auto-antibodies against thyroid gland. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Examination of Atypical Located Hydatid Cyst Disease in Eastern Turkey
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Bora, G.; Sünnetçioğlu, A.; Sünnetçioğlu, M.; Bora, A.; Yılmaz, Ö.; Çim, N.; Baran, A.İ.
The hydatid cyst disease is a zoonotic infection caused by Echinococcus granulosus. It usually causes infection in the liver and lungs. To a lesser extent, it may cause infection in the spleen, heart, bones and central nervous system. In this study, serological examination of hydatid cyst cases showing localization out of liver and lungs has been aimed. The clinical, radiological, and serological findings of a total 435 patients included to the examination between May 2010 and 2013, have been evaluated together. The indirect hemagglutination (IHA) test results were retrospectively scanned from hospital database of 288 patients among those who have received treatment because of hydatid cyst. The findings have been evaluated statistically through Chi-square trend analysis method according to ages and their localizations. According to the data obtained, 12 (7.2%) of 288 patients showing atypical localization in IHA (Indirect hemagglutination) results were positive and 13(9.6%) of them were found negative (p=3.393). According to the IHA results of 263 patients showing localization in liver and lungs 151 of them were positive and 112 of them were negative (p=3.393). The hydatid cyst is a disease that can be seen in every age range, besides, atypical localizations can also be seen in any age range. In terms of protecting public health, the public’s awareness should be raised and a greater emphasis on prevention methods are needed. © 2017 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Galactorrhea Case Unrelated To the Hyperprolactinemia Caused by Paliperidone Use: a Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Çim, E.F.A.; Çim, N.; Değer, Ö.D.
Paliperidone is an atypical antipsychotic derived from the combination of 9-hydroxy risperidone which is an active metabolite of risperidone with OROS (osmotic controlled-release oral delivery system) technology. Galactorrhea may develop as a result of hyperprolactinemia caused by paliperidone use. In our case, paliperidone was added to the treatment of a 35-year old female patient having a hypomanic episode. 2.5 months after the start of paliperidone treatment, the patient experienced galactorrhea and menstruation delays. Unexpectedly, normal hyperprolactinemia does not accompany galactorrhea and other symptoms. © 2015, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Histopathological and Mechanical Properties of Different Meshes in a Rat Model of Pelvic Prolapse Surgery
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Elçi, G.G.; Elçi, E.; Kaya, C.; Çim, N.; Kolusarı, A.; Erten, R.; Bulut, G.
Different types of mesh materials are used to support pelvic structures in urogynecologic procedures. Our aim was to compare histopathological and mechanical effects of Prolene®, UltraPro®, Vypro II®, and Permacol® meshes used in pelvic organ prolapse. Thirty Sprague-Dawley rats were randomized into five groups. Group 1 served as a sham-operated control (n=6); Prolene® was used in group 2 (n=6), UltraPro® in group 3 (n=6), Vypro II® in group 4 (n=6), and Permacol® in group 5 (n=6). A 0.5 × 1 cm mesh was placed between the paravaginal tissue and bladder. After 12 weeks, the rats were reoperated and meshes were excised. Histopathological tissue reactions were compared. The muscle penetration rate was 67% in the Prolene® group, which was significantly higher than that in the other groups (p=0.026). Minimum preserved postoperative surface area was seen with Prolene® at 0.31 cm2 and maximum with UltraPro® at 0.45 cm2, which was statistically significant. UltraPro® had the most preserved postoperative surface area and less shrinkage than the other meshes. The mesh materials cause an inflammatory reaction in surrounding tissue. Prolene® mesh had superior muscle penetration and tensile strength compared to the other materials. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Ileosigmoid Knot as a Cause of Acute Abdomen at 28 Weeks of Pregnancy: a Rare Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Toktaş, O.; Çim, N.
Ileosigmoid knot (ISK), also known as compound volvulus or double volvulus, is an unusual surgical emergency and is a rare condition leading to intestinal obstruction. ISK is an unusual phenomenon in the West but is relatively more common in some African, Asian, and Middle Eastern nations. This condition is serious, usually progressing rapidly to gangrene. Awareness of the condition is vital for the early diagnosis and optimal management of the patients. ISK should be considered in the differential diagnosis of patients presenting with ileus. In this report, we present a rare case of ISK in a 41-year-old, 28-week pregnant woman whose diagnosis was established intraoperatively. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Recurrent Spontaneous Ohss in a 10 Week Pregnant: a Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Çim, N.; Tolunay, H.E.; Boza, B.; Sayan, S.; Şahin, H.G.; Yıldızhan, R.
Ovarian hyperstimulation syndrome (OHSS) most often occurs in the context of assisted conception like in-vitro fertilization (IVF). OHSS can be a reason of acute abdomen. USG is very important in the diagnosis of OHSS. Severe complications can be seen in OHSS. Incidence of OHSS is increasing in recent years, so this situation should be kept in mind and the early diagnosis of OHSS is very important. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Trends and Causes of Maternal Mortality in Eastern Province of Turkey
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Çim, N.; Elçi, E.; Sayan, S.; Elçi, G.G.; Aksin, Ş.; Yıldızhan, R.
We aimed to analyse causes of maternal mortality cases in Eastern province of Turkey. Maternal mortality cases were retrospectively investigated. The cases were evaluated for age, gravida, age at first birth, gestational week, postpartum death time, educational status, illnesses in their history, high risk pregnan cies, pregnancy termination type, delivery methods and death causes. The distribution of these cases by type of death and years is examined. In addition, the causes of death were compared among groups according to their death pattern and years. A total of 69 maternal deaths were detected between January 2010 and December 2016. The maternal mortality rate was 20.1 per, 100000 livebirths. The mean age of the cases was 30.4 ± 7.6 and they had their first births when they were 20.9 ± 5.1 years old. Mean number of gravida was 3.9 ± 2.8. These cases were 32.3 ± 7.4 in the week of gestation when mortality occurred. The mean number of pregnancy follow-ups was 4.24 ± 4.0, postpartum direct maternal mortality time was 13.7 ± 25.5 days. The number of maternal mortality according to the years was respectively; 6, 12, 15, 16, 7, 13. When the causes of maternal mortality are examined; 26.1% of the cases had preeclamptic diseases, 15.9% had hemorrhage, 10.1% committed suicide, 8.7% had pulmonary embolism, 7.2% had cerebrova scular disease, 5.8% had heart disease, 5.8% had amnion fluid embolism, 4.3% had sepsis, 4.3% had traffic accidents, 4.3% had firearm injuries, 2.9% had malignancy, 1.4% had pneumonia, 1.4% had multiple organ failure, and 1.4% had died due to electric sho ck. Among the direct causes of death; preeclamptic diseases, hemorrhage and pulmonary embolism were the most common and among the causes of indirect death; cerebrovascular diseases, heart diseases and sepsis were the most common. Maternal mortality is an important obstetric complication that needs to be paid attention to. Preeclamptic diseases and hemorrhage continue to be the most common cause of maternal mortality. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.