Browsing by Author "Öner, A.C."

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Anti-Inflammatory and Hepatoprotective Activities of Trigonella Foenum-Graecum L
(2008) Öner, A.C.; Mercan, U.; Öntürk, H.; Cengiz, N.; Erten, R.; Özbek, H.
The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Trigonella foenum graecum L. (TFG). Anti-inflammatory activity: Control group was administered saline solution and reference group was administered indomethacin. TFG groups were injected TFG:olive oil (1:4) in doses of 0.1 mL/kg (TFG-I), 0.5 mL/ kg (TFG-II) and 1.0 mL/kg (TFG-III). Before the injections and three hours after the injections the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control group and CCl4 group received saline solution and 0.8 mL/kg CCl4:olive oil (1:1) respectively for seven days. TFG group and silibinin group (reference group) received TFG:olive oil (1:4) in doses of 0.1 mL/kg and 50 mg/kg, respectively for seven days. Blood samples were collected on the 8th day and the liver was extracted after the animals were killed. TFG had an anti-inflammatory effect matching to that of control group at all doses. It was found that reduction in the inflammation was 93.20% with indomethacin, 31.70% with TFG-I, 43.47% with TFG-II and 44.95% with TFG-III. Median effective dose (ED50) value of TFG was found to be 0.0645 mL/kg. TFG significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to CCl4 group. The histopathological findings showed a significant difference between the TFG and CCl4 groups. The results showed that TFG had considerable anti-inflammatory and hepatoprotective activities.
The Effect of Vitamin C and Vitamin E Administration for Treatment and Protection on Serum Vitamin Levels in Rats With Experimentally Fluorosis Created
(Ataturk Universitesi, 2021) Öner, A.C.; Çetin, S.; Yörük, I.H.; Dede, S.
This study aimed to determine the vitamins A-D and E levels in rats with experimental fluorosis and in whom vitamins, C and E were administered for prevention and treatment. One-month-old Wistar-Albino rats were used as material in the study. Nine groups of 8 animals each were studied. Sodium fluoride (NaF) solutions (150 mg/kg) prepared in drinking water were administered ad-libitum during the study. Vitamin C (100 mg/kg), Vitamin E (300 mg/kg) and Vitamin C + Vitamin E (100 mg/kg + 300 mg/kg) were administered to the protection group with water containing 150 ppm NaF for 16 weeks/day. Water containing 150 ppm NaF was given ad-libitum for 16 weeks in the treatment group, and then Vitamin C (100 mg/kg), Vitamin E (300 mg/kg) and Vitamin C + Vitamin E (100 mg/kg + 300 mg/kg) were administered along with normal drinking water for 4 weeks. At the end of sixteen weeks, blood samples were taken from the rats and their serums were removed. Serum Retinol, α-Tocopherol, Vitamin D3 levels were determined by HPLC. In the fluorosis group, it was found that there was no change in serum vitamin A and vitamin D levels with the application of vitamins C and E for treatment and protection, but a decrease in vitamin E level. As a result, it was concluded that the administration of vitamin E is effective in both the prevention and treatment of fluorosis cases. © 2021 Ataturk Universitesi. All rights reserved.
Investigation of Acute Liver Toxicity and Anti-Inflammatory Effects of Artemisia Austriaca J. Jacq
(2008) Mercan, U.; Öner, A.C.; Öntürk, H.; Cengiz, N.; Erten, R.; Özgökç, F.; Özbek, H.
The aim of this study was to investigate hepatoprotective and anti-inflammatory activities of Artemisia austriaca J. Jacq. essential oil (AA). Artemisia groups were injected AA in doses of 0.05 mL/kg (AA-I), 0.1 mL/kg (AA-II) and 0.2 mL/kg (AA-III) in both inflammatory and hepatotoxicity experiments. The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Artemisia did not have an anti-inflammatory effect matching to that of control group at any doses. It was found that reduction in inflammation was 96.62% with indomethacin, 5.71% with AA-I, 10.54% with AA-II and 31.37% with AA-III. AA-I significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the AA-I and CCl4 groups. The results showed that Artemisia austriaca J. Jacq. had considerable hepatoprotective activity while it did not show an anti-inflammatory activity.