Browsing by Author "Öner, A.F."

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Abo and Rh Blood Groups Frequency in Men and Women Living in Eastern Turkey
(2006) Dilek, I.; Demir, C.; Bay, A.; Akdeniz, H.; Öner, A.F.
Objective: ABO and Rh blood groups which are basic for determination of blood compatibility consist of the most important tests of blood center. In this study, we aimed to find out the rates of ABO and Rh blood groups in male and female donors in our region. Therefore, donors attending to our blood center within the last five years were investigated taken into account their gender. Methods: Blood groups were examined by gel-centrifugation or tube agglutination methods. Results: Out of totally 33.193 individuals, 14.716 were female (44.3%) and 18.477 males (55.7%), and average age was 34 (range 20-60 years old). Taken into account the whole donors, A blood type was found as 43.8%, O blood type 30.8%, B blood type 16.2% and AB blood type 8.6% in rate. With respect to blood type frequency in genders group A was in the rate of 44.1% and 43.6%, group O 31% and 30.5%, group B 16.3% and 16.1% and group AB 8.6% and 9.8% in women and men, respectively. The Rh positivity rate into totally whole donors was 85.5%, being 86.0% in men and 84.8% in women. Conclusion: ABO and Rh blood groups rates were very near to each other in women and men, and also the average rate was very similar to averages in Turkey.
Acute Myeloblastic Leukemia-Associated Marfan Syndrome and Davidoff-Dyke Syndrome: a Case Report
(2008) Demir, C.; Bay, A.; Dilek, I.; Öner, A.F.
We present herein a 23-year-old man with acute myeloblastic leukemia (AML) associated with Davidoff-Dyke-Masson syndrome (DDMS) and Marfan syndrome (MS). The diagnosis of DDMS was based on findings including left facial asymmetry, left hemiparesis, mental retardation, right cerebral hemiatrophy, dilatation of the ipsilateral lateral ventricle and calvarial thickening. The diagnosis of MS was based on clinical findings including tall stature, myopia, retinitis pigmentosa, blue scleras, scoliosis, pectus excavatum, arachnodactyly and low ratio of upper/lower body segment. The patient developed hepatosplenomegaly, gingival hypertrophy and pancytopenia. Peripheral blood film and bone marrow examination showed that most of nucleated cells were blasts; immunophenotype of those cells showed CD11+, CD13+, CD14+, CD33+ and HLA-DR+. These findings confirmed the diagnosis of AML (FAB-M5). After induction chemotherapy, remission was obtained. To the best of our knowledge, our case is the third report of AML in MS syndrome, while AML associated with DDMS and MS has not been previously reported in the literature.
An Analysis of Children With Brucellosis Associated With Haemophagocytic Lymphohistiocytosis
(2016) Karaman, K.; Akbayram, S.; Kaba, S.; Karaman, S.; Garipardiç, M.; Aydin, I.; Öner, A.F.
This retrospective study included seven paediatric cases aged from 4 to 14 (10.2±3.4) years with pathologically proved haemophagocytic lymphohistiocytosis from a single institution during 2009 and 2013. Over this time period, 496 patients with brucellosis were diagnosed. None of the patients (3 boys and 4 girls) had a history of any haematologic disorder. All patients had an anamnesis for recently consumed unpasteurised homemade dairy products or had a contact history with sheep and/or cows. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titres were 1: 1280 in seven patients. Blood culture was positive for Brucella melitensis in three patients (42%). Bone marrow cultures were positive for B. melitensis in four patients (57%). Fever was present in all patients (100%) with haemophagocytic lymphohistiocytosis. The other most common symptoms were malaise, myalgia, anorexia, sweating and weight loss. In addition, sweating was observed in five patients, and lymphadenopathy, petechiae, and weight loss were observed in one patient. Hepatomegaly, splenomegaly, and hepatosplenomegaly were found in four (57%), six (85%) and four (57%), patients, respectively. Haemophagocytosis was documented in bone marrow examinations of all children except in two cases. All patients recovered completely, and their peripheral blood counts returned to normal by 2 to 4 weeks after antibiotic treatment of brucellosis.
Auditory Brainstem Response in Children With Iron Deficiency Anemia
(2003) Çankaya, H.; Öner, A.F.; Egeli, E.; Çaksen, H.; Üner, A.; Akçay, G.
To investigate the neurosensorial influences with auditory brainstem response (ABR) in iron deficiency anemia. We recorded ABR in 33 children with iron deficiency anemia followed and in 31 healthy children (control group 1, 0-12 months, control group 2, 13-36 months, control group 3, 37-60 months) as a control group. The patients and controls were divided into three group: group I, at 12 months of age, group II, 13-36 months, and group III, 37-60 months. In all groups, composed latency time, inter-peak latency, amplitude of peaks, I-V wave amplitude ratio and waveform were evaluated and compared with control groups. In group I, I-V interpeak latency was increased compared with control group 1 (4.58 vs. 4.20 ms, p < 0.05). In group II, Wave V latency time and III-V interpeak latency were increased compared with control group 2 (6.21 ms vs. 5.63 ms. p < 0.005 and 0, 48 vs. 0.22 p < 0.005, respectively). In group III, wave I latency time was increased compared with control group 3 (1.56ms vs. 1.46 ms) (p < 0.05). We considered that increases in ABR latencies might be explained by delayed maturation of myelinisation, which requires iron, and/or by dysfunction of iron containing enzymes.
Beta-Thalassemia Mutations in the East of Turkey
(2001) Öner, A.F.; Özer, R.; Üner, A.; Arslan, Ş.; Gümrük, F.
This study was planned to determine the frequency of β-thalassemia trait and mutations in Van Lake region, which is in the eastern part of Turkey, surrounded by Iran in the east and by Iraq in the south. This study consist of 1014 healthy students, between the age of 12 and 18 years who are studying in boarding schools in Van city and cities surrounding Van Lake that includes Van, Aǧri, Hakkari, Bitlis, Muş and Siirt. The students were randomly selected according to their school numbers. Their origin was not taken into consideration in selection. Complete blood counts were performed on all donors. The accepted lower limit of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were 78 fL and 27 pg respectively. HbA2 was measured by DE-52 microcolumn chromatography method. β-Thalassemia trait with high HbA2 was found in 6 children. β-Thalassemia homozygous form of -30 (T-A) mutation was determined in one child and HbD-Los Angeles heterozygous in another. The β-thalassemia homozygous individual was accepted as two cases in prevalence calculation. We found that the prevalence of β-thalassemia trait was 0.78% in this area. In DNA analyses, there were β-thalassemia gene mutations of FSC 8/9 (+G), -30 (T-A), IVS I-110 (G-A), IVS II-1 (G-A) and IVS I-130 (G-A) in 3, 2, 1, 1 and 1 individuals, respectively. We conclude that although five different β-thalassemia mutation exist in Van Lake region, β-thalassemia is not a potential risk in the east of Turkey.
A Case of Isolated Cns Relaps With Atipik Clinical Presentation in an Acute Myeloblastic Leukemia Patient
(2005) Bay, A.; Öner, A.F.; Etlik, Ö.; Doǧan, M.; Izmirli, M.
After the recent advances in chemotherapy and supportive care, survival and the number of extrameduller relaps have increased in childhood acute myeloblastic leukemia (AML). However isolated central nervous system (CNS) relaps is a rare event in AML. We reported a 7 years old child, who presented with dyspnea, diagnosed isole CNS relaps at the 30th week of maintance chemotherapy protocol of AML. He admitted to our emergency service with the complain of dispne. Respiratory track infection or other pathology was not found on phsycal examination and labaratuary tests. On follow up, lumbar puncture was performed to the patient having no any improvement in dispne to evaluate the CNS disorders. Cerebro spinal fluid examination showed a lot of blastic cell and thus isolated CNS relaps was diagnosed. Cranial MRI showed an enlargement at pons and bulbus corresponding leukemic infiltration. Dispne were resolved just after the beginning of administration intratechal and systemic reinduction chemotherapy.
A Case of Wilms’ Tumor With Spinal Cord Involvement
(2003) Bay, A.; Akbayram, S.; Öner, A.F.; Çaksen, H.; Köseoğlu, B.; Ünal, Ö.
Wilms’ tumor is the most common renal tumor of childhood. However, spinal cord involvement has rarely been reported in children with Wilms’ tumor. In this article, we report a 5-year-old boy with Wilms’ tumor who had the unusual presentation of spinal cord involvement. Our purpose is to emphasize that spinal cord involvement may be seen in children with Wilms’ tumor. © 2003, IOS Press. All rights reserved.
Changes of Hemostatic Factors in Children With Acute Lymphoblastic Leukemia Receiving Combined Chemotherapy Including High Dose Methylprednisolone and L-Asparaginase
(Harwood Academic Publishers GmbH, 1999) Öner, A.F.; Gürgey, A.; Kirazli, S.; Okur, H.; Tunç, B.
In this study, protein C (PC), protein S (PS), heparin cofactor II (HCFII), prothrombin fragment 1 + 2 (PF 1,2), thrombin-antithrombin III complex (TAT), von Willebrand factor (vWF) and thrombomodulin (TM) were investigated in 19 patients with acute lymphoblastic leukemia, (ALL) receiving combined chemotherapy including L-asparaginase (L-ASP) and high dose methylprednisolone (HDMP). HDMP was administered in doses of 30 mg/kg/day for 7 days, and 20 mg/kg/day for another 7 days. In order to evaluate the effect of HDMP on the hemostatic system, the 8 patients studied here received HDMP (30 mg/kg/day) therapy for 4 days before the combined chemotherapy. These parameters were also studied in 12 healthy children as a control group. PC levels were normal in the patients while PS levels were decreased both before and after combined chemotherapies. Patients with ALL have laboratory signs of coagulation activation such as PF 1,2, TAT prior to initiation of chemotherapy. With combined chemotherapy, TAT levels were found to be normal while PF 1,2 were not. TM levels were found to be increased both before and after therapies whereas HCFII and vWF levels were not different from those of the control group. The short course of HDMP therapy did not prominently influence these hemostatic parameters. These results indicate that both the malignant process and the drugs used in combined chemotherapy cause a decrease in natural inhibitors and an increase in procoagulant activity and endothelial injury. These hemostatic changes may contribute to a thrombotic tendency in the patients with ALL.
Effects of High-Dose Methylprednisolone Therapy on Lymphocyte Subtypes in Patients With Acute Immune Thrombocytopenic Purpura
(2005) Öner, A.F.; Bay, A.; Kuru, M.; Üner, A.; Arslan, Ş.; Dilek, I.
The aim of this study was to determine the effect of high-dose methylprednisolone (HDMP) on lymphocyte subtypes, CD4/CD8 ratio and clinical efficacy of the treatment in children with acute immune thrombocytopenic purpura (ITP). The study consisted of 21 children (aged between 1.5-14 years) with ITP treated with HDMP for 7 days. Absolute lymphocyte count, CD4+ and CD8+ T lymphocyte levels were examined on peripheral blood and CD4/CD8 ratio was calculated before and after HMTP treatment (on 0 and 8th days) in all subjects. There was no statistically significant difference for age and sex between the study and the control group. A significant reduction was observed in the percentage of CD4+ lymphocyte (39.0 ± 7.5% vs 29.3 ± 8.1%, p= 0.001), CD8+ lymphocyte (27.1 ± 7.2% vs 23.7 ± 8.3%, p= 0.03), CD4+/CD8+ (1.5 ± 0.5 vs 1.3 ± 0.4, p= 0.02) and the absolute number of CD4+ lymphocyte count (1694.99 ± 1019 vs 1199.12 ± 612, p= 0.038). These findings indicated that HDMP treatment may cause a decrease in the percentage of CD4+ and CD8+ T-lymphocyte and ratio of CD4+/CD8+ lymphocyte in patients with acute ITP. We suggest that the effectiveness of steroids may depended upon the suppression of CD4 T-lymphocyte and sequential monitoring of circulating lymphocyte subtypes may be used to predict the clinical effects of steroid treatment.
Efficacy of Intravenous Anti-D Therapy in Childhood Chronic Idiopathic Thrombocytopenic Purpura
(2006) Bay, A.; Öner, A.F.; Doǧan, M.; Açikgöz, M.; Dilek, I.
In this study we examined eleven patients with chronic immune thrombocytopenic purpura (ITP) who received anti D retrospectively. All of the cases have Rh+ blood group and non-splenectomized. Anti D was given 30μg/kg/dose on 0, 1, 7, 14, 21, 28 days by intravenous infusion in one hour. Three of them (27%) had complete response, three of them (27%) had partial response, three of them (27%) had minor response, and two of them (18%) didn't response. On following, only one patient who responded initially, had high trombocyte count over 1 year. The other patient's trombocyte counts were decreased to the initial level within 1-3 months after the treatment. We did not observe any important side effect. In conclusion, anti D should be considered as a therapeutic option for childhood chronic ITP.
Evaluation of the Causes of Early and Late Thrombocytopenia in the Newborn
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2018) Karaman, K.; Demir, N.; Çetin, M.; Geylan, H.; Değer, İ.; Başaranoğlu, M.; Öner, A.F.
Objective: Thrombocytopenia is the most common hematological disorder that is encountered in the neonatal intensive care unit (NICU). The incidence of thrombocytopenia in neonates may varies greatly depending upon admitted patients population of unit. This study was performed on neonates admitted to Yuzuncu Yil University of Dursun Odabaş Medical Center of NICU, the incidence and causes of thrombocytopenia. Material and Methods: This retrospective study was conducted on the medical records of all neonates hospitalized at our hospital between May 2012 and March 2015 and those with thrombocytopenia were included in the study. The laboratory results of these newborns were retrospectively screened from the computer program and files, and included in the study were those with a thrombocytopenia level of less than 150.000/μL. Results: About 2780 patients were admitted to our neonatal intensive care unit during the study period. Of the 2780 neonates, 117 (4.2%) had thrombocytopenia (60.7% early onset and 39.3% late onset). Seventy-two of them (61.5%) were preterm. Intrauterine growth restriction, maternal hypertension, respiratory distress syndrome and sepsis were more common causes. Severe thrombocytopenia (<50.000/µL rate was found in 27% of neonates. In addition, although the rate of thrombocytopenia in asfixia was reported in the literature as 12-14%, this rate was 6.8% in our cases. There was no relation between occurrence of thrombocytopenia and gender. Conclusion: This study reveals that the causes of neonatal thrombocytopenia may show variations. In our study, intrauterine growth restriction, maternal hypertension, respiratory distress syndrome, and sepsis seem to be important risk factors for thrombocytopenia in neonates. Copyright © 2018 by Türkiye Klinikleri.
High-Dose Steroid-Related Osteonecrosis in a Four-Year Child With Acute Lymphoblastic Leukemia
(2005) Bay, A.; Öner, A.F.; Etlik, Ö.; Doǧan, M.
Osteonecrosis is an uncommon complication of acute lymphoblastic leukemia. One of the risk factor is high-dose corticosteroid therapy. The highest incidence of osteonecrosis is observed in children 9 to 18 years old at diagnosis and it is a rare condition below 5 years of age. We describe a 4 year-old child with acute lymphoblastic leukemia and complaints of progressive bone pain and walking difficulty who developed osteonecrosis and bone fracture after two remission induction chemotherapy.
Hypnotic Intervention for Pain Management in a Child With Sickle Cell Anemia
(2001) Aǧargün, M.Y.; Öner, A.F.; Akbayram, S.
Images in Hematology
(2006) Öner, A.F.; Bay, A.; Açikgöz, M.
Investigation of Correlations Between Joint Health, Functionality, and Mri Score in Hemophilic Arthropathy of the Elbow Joint: Cross-Sectional Study
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Tat, A.M.; Özkan, S.; Tat, N.M.; Karaman, K.; Öner, A.F.
Hemophilic arthropathy (HA) of the elbow joint should be examined separately from the knee and ankle because of the anatomical and biomechanical differences of the elbow. The aim is to investigate possible correlations between age, range of motion (ROM), muscle strength, upper extremity functions, joint health and radiological findings. Twenty-seven joints of 20 patients aged 11-30 years with findings of HA in elbow were evaluated. International Prophylaxis Study Group Magnetic Resonance Imaging (IPSG MRI) score was used in the radiological evaluation. In physical evaluations, ROM and muscle strength were measured by goniometer and digital dynamometer, respectively. Joint health was evaluated with Hemophilia Joint Health Score-Elbow Point (HJHS-EP) and upper extremity functionality with Quick-Disability of Arm Shoulder and Hand (Q-DASH). The age was strongly correlated with HJHS-EP, loss of extension and pronation ROM and moderately correlated with IPSG MRI score. HJHS-EP showed strong correlation with loss of extension. There were a moderate correlation between Q-DASH and muscle strength of the elbow. The IPSG MRI scores were not significantly correlated with physical examinations. The elbow joint should be evaluated both radiographically and physically and these assessments cannot be alternatives to each other. Even goniometric assessment of elbow extension alone may provide important information about joint health. Functionality can be improved by increasing muscle strength. Since the deterioration in physical and radiographic examinations with age, it is recommended to conservatively or surgically treat of the elbow joint with physiotherapy at early ages. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Massively Enlarged Kidneys Due To Leukemic Infiltration in a Child
(2010) Doǧan, M.; Bay, A.; Bora, A.; Açikgöz, M.; Öner, A.F.
A few cases with bilateral renal enlargement in acute lymphoblastic leukemia were reported in literature. In this article, we reported an unusual case of a child with precursor B-ALL presenting with massively enlarged bilateral unobstructed kidneys and acute renal failure. Renal involvement of ALL should be taken into consideration in case with massively enlarged bilateral kidneys in radiological examination. Based on radiological, clinical and laboratory findings including bone marrow aspirate examination, the patient could be diagnosed as ALL without renal biopsy.
Neutropenic Enterocolitis in a Child With Acute Myelogenous Leukemia
(TIP ARASTIRMALARI DERNEGI, 2011) Akbayram, S.; Avcu, S.; Kizilyildiz, B.S.; Taşkin, G.; Sari, S.; Öner, A.F.
Neutropenic enterocolitis is a potentially life-threatening complication of malignancies and also the other neutropenic conditions. It characterized by typically clinical course of fever, diarrhoea and abdominal pain that may be localized to the right lower quadrant with radiological evidence of ileocecal inflamation. We present a case of an 9-year-old girl with neutropenic enterocolitis who managed successfully by medical treatment and show radiological findings consistent with enterocolitis.
Relapsing Hepatitis a in Children: Report of Two Cases
(2002) Arslan, Ş.; Çaksen, H.; Öner, A.F.; Odabaş, D.; Rastgeldi, L.
Viral A hepatitis is a self-limited infection occurring predominantly among children usually as an anicteric often subclinical illness. After a stage of typical hepatitis A, a biphasic or relapsing form of viral hepatitis A (R-HA) may occur. Although relapse occurs in 3 to 21% of patients with acute hepatitis A, the patients with R-HA have been unusually reported in the literature. In this article, we report two children with R-HA because of unusual presentation and to draw attention to the importance of R-EA.
Rubella Seroprevalence in Adolescent Girls in the Eastern Region of Turkey
(2002) Çaksen, H.; Ceylan, A.; Ceylan, N.; Arslan, S.; Öner, A.F.; Kirimi, E.; Gölbasi, C.
Seropositivity Rates of Hbsag, Anti-Hcv, Anti-Hiv and Vdrl in Blood Donors in Eastern Turkey
(2007) Dilek, I.; Demir, C.; Bay, A.; Akdeniz, H.; Öner, A.F.
Infections caused by hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency viruses (HIV) remain the leading most important health problems worldwide. Screening tests such as HBsAs, anti-HCV, anti-HIV and VDRL are mandatory tests to look at before transfusion of blood or blood components. In this study, donors who applied to our Blood Center in a nine-year period were retrospectively evaluated with respect to HBsAs, anti-HCV, anti-HIV and syphilis seroprevalence. HBsAg, anti-HCV and anti-HIV were examined by microparticle ELISA system, and syphilis antibodies were screened by a syphilis test device. Of the total 39,002 individuals, 16,601 (42%) were females and 22,401 (58%) were males. HBsAg positivity was found in 2.55%, anti-HCV in 0.17%, anti-HIV in 0.036%, and VDRL in 0.057% of overall donors. As a result, HBsAg, anti-HCV, anti-HIV and VDRL seropositivity rates in donors living in our region were found lower than those in many regions of Turkey. Nevertheless, because there is no screening method to reduce the risk resulting from transfusion to zero, it appears that it is essential to adopt strict criteria in the selection of donors and to avoid unnecessary transfusion. © Turkish Society of Hematology.