Browsing by Author "Öner, AF"

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A Case of Immune Thrombocytopenic Purpura Presenting With Recurrent Intracranial Hemorrhage
(Wiley, 2005) Bay, A; Öner, AF; Etlik, Ö; Çaksen, H
A Case of Typhoid Fever Associated With Hemophagocytic Syndrome
(Elsevier Science inc, 2003) Çaksen, H; Akbayram, S; Öner, AF; Kösem, M; Tuncer, O; Atas, B; Odabas, D
Childhood Brucellosis Is Still a Severe Problem in the Eastern Region of Turkey
(Sage Publications inc, 2002) Çaksen, H; Arslan, S; Öner, AF; Cesur, Y; Ceylan, A; Atas, B; Abuhandan, M
Cranial Computed Tomography in Purulent Meningitis of Childhood
(informa Healthcare, 2004) Tuncer, U; Çaksen, H; Arslan, S; Atas, B; Üner, A; Öner, AF; Odabas, D
The cranial computed tomography (CT),findings of 48 children with purulent meningitis were examined, prospectively, to determine the importance of cranial CT findings on the prognosis of childhood meningitis, in a developing country. The age of children ranged from 2 months to 13 years. Of 48 patients, 29 (60.5%) survived without sequelae, 13 (27%) survived with sequelae, and six (12.5%) died. Cranial CT was normal in 21 (43%) patients of 48 children with meningitis at admission. Abnormal CT findings were detected in 10, H, and 6 children in the groups of survived without sequelae, survived with sequelae, and deaths, respectively, at admission (p < .05) We found that CT scan results were correlated with neurological signs (p < .05). At least one or more cranial CTs were was re-taken in children in whom the first CT revealed abnormal findings; we did not find a statistically significant difference for the follow-up CT findings between the groups (p > .05). Hydrocephalus and subdural effusion were the commonest abnormal CT findings. In conclusion, our findings showed that cranial CT may safely be used to detect intracranial complications of meningitis in childhood and the ratio of sequelae and death were more common in children with abnormal cranial CT than those of normal cranial CT findings. Additionally, there was a positive correlation between CT scan results and neurological signs.
Deadly Nightshade (Atropa Belladonna) Intoxication
(Arnold, Hodder Headline Plc, 2003) Çaksen, H; Odabas, D; Akbayram, S; Cesur, Y; Arslan, S; Üner, A; Öner, AF
Deadly nightshade (Atropa belladonna) intoxication has been infrequently reported in both children and adults in the literature. In this article, the clinical and laboratory findings of 49 children with acute deadly nightshade intoxication are reviewed. Our purpose was to enlighten the findings of deadly nightshade intoxication in childhood. The most common observed symptoms and signs were meaningless speech, tachycardia, mydriasis, and flushing. None of the children required mechanical ventilation or died in our series. The patients were categorized into two groups, mild/moderate and severe intoxication. Children with and without encephalopathy were accepted as severe and mild/moderate intoxication, respectively. While 43 children were placed in the group of mild/moderate intoxication, six were in severe intoxication group. We found that meaningless speech, lethargy, and coma were more common, but tachycardia was less common in the severe intoxication group (children with encephalopathy) (P < 0.05). In the treatment, neostigmine was used in all children because of no available physostigmine in our country. In conclusion, our findings showed that the initial signs and symptoms of acute deadly nightshade intoxication might be severe in some children, but no permanent sequel and death were seen in children. We also showed that meaningless speech, lethargy, coma, and absence of tachycardia were ominous signs in deadly nightshade intoxication in childhood. Lastly, we suggest that neostigmine may be used in cases of deadly nightshade intoxication if physostigmine cannot be available.
Diminished Platelet Aggregation in Patients With Iron Deficiency Anemia
(Lippincott Williams & Wilkins, 1999) Çaliskan, Ü; Öner, AF; Kabakus, N; Koç, H
To evaluate platelet function in iron deficiency anemia, using impedance (in whole blood) and optic tin platelet-rich plasma methods, platelet aggregation analyses were performed in 42 children with iron deficiency anemia at the time of diagnosis and after iron therapy. Collagen-induced platelet aggregation was decreased in patients before therapy compared to after therapy and control levels as indicated by the two methods while adenosine diphosphate (ADP)-induced platelet aggregation was decreased only by the whole blood method. Platelet aggregation with epinephrine, performed only by the optic method, was not altered in patients with iron deficiency anemia. Platelet counts were found to be increased in patients with iron deficiency anemia, and decreased with therapy. These results indicate that some platelet functions are decreased in patients with iron deficiency anemia. These decreased functions may be compensated by increased platelet numbers.
The Effect of Short-Course High-Dose Methylprednisolone on Peripheral Blood Cd34+ Progenitor Cells of Children With Acute Leukemia During Remission Induction Therapy
(Turkish J Pediatrics, 2002) Tunç, B; Öner, AF; Hiçsönmez, G
This study was undertaken to determine the effect of short-course high-dose methylprednisolone (HDMP) treatment on peripheral blood (PB) CD34(+) progenitor cells during remission induction treatment in 11 children with newly diagnosed acute leukemia (7 with ALL, 4 with AML) whose bone marrow (BM) cells expressed fewer than 5% CD34 at the time of diagnosis. All children who had no infection were given HDMP as a single daily oral dose of 30 mg/kg for the first four days of induction therapy. The number of CD34(+) progenitor cells were determined by flow cytometry before and after four days of HDMP treatment. While the number of PB blast cells significantly decreased after only a four-day course of HDMP treatment, the number of PB CD34(+) progenitor cells increased in all patients. In addition, after four days of HDMP treatment polymorphonuclear leukocytes (PMN) and mononuclear cells (MNC) increased significantly (p < 0.05). We suggest that the potential beneficial effects of HDMP in the induction treatment of acute leukemia may occur partly by the stimulation of PB CD34(+) hematopoietic progenitor cells in a short period of time.
Immunoglobulin Subgroups in Children With Febrile Seizures
(Blackwell Science Asia, 2001) Çaksen, H; Öner, AF; Arslan, S; Kan, MC; Cesur, Y; Üner, A
Background: The aim of the present study was to determine whether or not there was a role for immunoglobulin (Ig) or IgG subgroups in the pathogenesis of febrile seizures (FS). Methods: Serum levels of IgA, total IgG, IgM, IgE, IgG1, IgG2, IgG3 and IgG4 were measured in 34 children with FS and in 37 healthy children used as a control group. Both patients and controls were divided into two groups according to age (group I, 6-24 months; group II, 25-72 months). Results: Compared with controls, mean IgG4 levels in patients were found to be decreased in both groups I and II (group I: 95+/-14 vs 57+/-5, respectively, P=0.01; group II: 178.5+/-38.5 vs 65.1+/-24.5, respectively, P <0.01), while mean IgG2 levels were found to be decreased only in group II patients (170+/-16 vs 103+/-22; P <0.05). Conclusions: The results of the present study suggest that Ig subclass deficiencies may be responsible for the infections connected with FS or that they may be related to the pathogenesis of FS in some children.
Platelet Functions in Patients With Protein-Energy Malnutrition
(Lippincott Williams & Wilkins, 2001) Üner, A; Çaliskan, Ü; Öner, AF; Koç, H; Kasap, AF
Protein-energy malnutrition (PEM) has been known to cause several organ damages or dysfunctions. In this study, using optic method, platelet aggregation (PA) analyses were performed in patients with PEM. Adenosine diphosphate (ADP)- and collagen-induced PA were significantly decreased in the patients with PEM. The low values reached normal when the patients caught up the optimal growing curve for their age. PA with ristocetin and epinephrine were not significantly altered in the patients. Conversely, mean platelet count was increased at the beginning compared to those of after therapy and to the control. These results indicate that some platelet functions (ADP- and collagen-induced platelet aggregations), as well as other body functions, have been decreased in PEM.
Primary Varicella Infection Associated With Stevens-Johnson Syndrome in a Turkish Child
(Japanese dermatolgical Assoc, 2005) Bay, A; Akdeniz, N; Çalka, Ö; Kösem, M; Öner, AF; Dogan, M
Stevens-Johnson syndrome (SJS) is defined as a severe erythema-multiforme-like eruption of the skin and lesions of the oral, genital and anal mucosa and hemorrhagic crusting on the lips; it is associated with fever, headache, and arthralgia. The disease is a part of a continuum of immunologically mediated mucocutaneous diseases at various grades of severity. SJS is often induced by drugs, but the pathophysiologic mechanism is completely unknown. Patients and their first degree-relatives may have genetic defects in their metabolic pathways that lead to the accumulation of toxic metabolites. However, viral infections are known triggers of this skin disorder. Varicella zoster virus has been only very rarely reported as an etiological agent in SJS, despite its high incidence as a pathogen in childhood. In this study, we report a case of primary varicella infection associated with SJS because of its rare presentation. To the best of our knowledge, our case is the youngest child in the literature.
Relapse in Hairy Cell Leukemia Due To Isolated Nodular Skin Infiltration
(Taylor & Francis Ltd, 2001) Yetgin, S; Olcay, L; Yenicesu, I; Öner, AF; Çaglar, M
Report of Eight Infants With Acute Infantile Hemorrhagic Edema and Review of the Literature
(Japanese dermatolgical Assoc, 2002) Çaksen, H; Odabas, D; Kösem, M; Arslan, S; Öner, AF; Atas, B; Ceylan, N
Acute infantile hemorrhagic edema (AIHE) is a cutaneous leukocytoclastic vasculitis, clinically characterized by the symptom triad of fever, large purpuric skin lesions, and edema. The clinical picture has a violent onset, a short benign course, and spontaneous complete recovery. In this article, we present eight patients who were admitted with rashes on the skin and edema on the eyelids and extremities, and were diagnosed with AIHE according to their clinical and histopathological features (immunohistological study was also performed in three of them). Our purpose was to emphasize that, aside from Henoch-Schonlein purpura, meningococcemia, septicemia, and purpura fulminans, AIHE benign disorder should also he considered in the differential diagnosis to determine the clinical course and treatment protocol in patients with purpuric rashes.
Silent Stroke in a Case of Β-Thalassemia Major Associated With Chronic Renal Failure and Diabetes Mellitus
(B C decker inc, 2003) Çaksen, H; Odabas, D; Akbayram, S; Öner, AF; Arslan, S; Cesur, Y; Üner, A
Severe anemia, growth retardation, diabetes mellitus, cardiac disorders, and, infrequently, stroke are well-known complications of thalassemia major. We report a girl, age 7 years, 2 months, with beta-thalassemia major associated with chronic renal failure, diabetes mellitus, and cardiomyopathy in whom a silent stroke was noted during follow-up. She was diagnosed with thalassemia major at age 6 months, chronic renal failure at age 3 years, 3 months, and diabetes mellitus and cardiomyopathy at age 7 years. Although cranial computed tomography was found to be normal at the age of 3 years, 3 months, magnetic resonance imaging showed cerebral infarct in the right frontal region at 7 years, 2 months. A thrombophilic panel revealed increased factor VIII and decreased protein C concentrations. She died from disseminated intravascular coagulation at age 7 years, 9 months. We did not record any clinical findings of stroke during her follow-up. We think that diabetes mellitus, dilated cardiomyopathy, and increased factor VIII and decreased protein C concentrations led to the occurrence of cerebral infarct. In conclusion, we emphasize that children with thalassemia major should be monitored closely for stroke. We also suggest that stroke can show a silent progression in severely affected children, as in our case.
Unusual Presentation of Infantile Hemangioendothelioma
(Wiley, 2005) Bay, A; Öner, AF; Etlik, O; Koseoglu, B; Kaya, A
Infantile hemangioendothelioma is a rare benign hepatic tumor arising from mesenchymal tissue. Most of the cases present with congestive heart failure and asymptomatic abdominal mass were before 6 months of age. We described a patient with projectile vomiting, which is quite an Unusual presentation. Following surgical resection, neither recurrence nor symptoms were seen in 2 years of follow-up. (C) 2004 Wiley-Liss, Inc.
Use of Interferon Alpha-2b and Prednisolone in the Treatment of Severe Intractable Diarrhea in a Child With Systemic Mastocytosis
(Blackwell Publishing Asia, 2003) Çaksen, H; Odabas, D; Öner, AF; Cesur, Y; Arslan, S; Akbayram, S; Erol, M