Browsing by Author "Öztürk, M."

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Comparison of Serum Cytokeratin-18, Cea and Ca 19-9 Levels in Esophageal and Gastric Cancers
(2004) Tuncer, I.; Dülger, H.; Uygan, I.; Öztürk, M.; Kotan, Ç.; Şekeroǧlu, R.
The aim of this study was to determine clinical value of alone and combined use of serum cytokeratin (CK)-18, carcinoembryonic antigen (CEA) and CA 19-9 in esophageal squamous cell carcinoma and gastric adenocarcinoma. Serum tumor markers were measured in 60 patients who had esophageal squamous cell carcinoma or gastric adenocarcinoma. Thirty healthy subjects served as controls. In patients with gastric adecarcinoma serum CK-18 levels were significantly increased compared to both esophageal squamus cell carcinoma and control groups (p<0.01, p<0,05 respectively). But there was no significant difference in CK-18 levels between esophageal squamous cell carcinoma patients and healthy subjects (p>0.05). On the other hand, serum CEA and CA 19-9 levels did not differ between groups (p>0.05). The sensitivity of serum CK-18, CEA and CA19- 9 in esophageal squamous cell carcinoma were 53%, 70% and 66%, respectively. For gastric adenocarcinoma, the sensitivity of each tumor marker was similar 70%, 70% and 70%, respectively. CK-18/CA19-9 combination in the esophageal (83%) and gastric carcinomas (93%) were found to be more sensitive than other tumor markers when these markers were evaluated in combination. CEA exhibited the highest sensitivity for esophageal squamous cell carcinoma compared to CK-18, and CA19-9. However, the sensitivity of all tumor markers in gastric adenocarcinoma were similar. The combination of CK-18 and CA19-9 could increase the diagnostic sensitivity in esophageal and gastric carcinomas.
Determination of Lethal Doses of Volatile and Fixed Oils of Several Plants
(2004) Özbek, H.; Öztürk, M.; Öztürk, A.; Ceylati, E.; Yener, Z.
Objective: To determine lethal doses of fixed and/or volatile oils extracted from leafs or fruits of Pimpinella anisum, Foeniculum vulgare, Sesamum indicum, Eugenia caryophyllata, Nigella sativa, Urtica pilulifera, Apium graveolens, Cuminum cyminum, Coriandrum sativum and Thymus fallax, Method: Swiss albino mice were injected intraperitoneally with different concentrations of the extract and results were evaluated with the method of probit analysis. Results: Maximum volume of oil administered to mice was kept below 0.5 ml. The oils of Sesamum indicum and Urticapilulifera was completely non-lethal even at doses reaching 12.8 ml/kg and considered non-toxic. Conclusion: Lethal doses were determined for all other plants and LD1, LD10, LD50, LD90 and LD99 values were given.
Differential Diagnosis of Papillary Thyroid Carcinoma: Immunocytochemical Study of 112 Cases
(2005) Kösem, M.; Polat, S.; Öztürk, M.; Kotan, Ç.; Özbek, H.; Algün, E.
Papillary carcinoma is diagnosed mainly by its classical papillary structures and nuclear changes. However similar structural and cytological features may also be seen in other lesions of thyroid. Immunohistochemical staining methods help in these circumstances that cytological features do not suffice for differential diagnosis. In this study we stained 112 parafin-embedded blocks with thyroidal lesions (60 papillary carcinoma and 52 other benign or malignant thyroidal lesions) with HBME-1, CK-19, S-100 and EMA. Papillary carcinomas were stained 8.3% weakly, 90% moderately and strongly with HBME-1; 11.7% weakly, 88.3% moderately and strongly with CK-19; 50% weakly, 50% moderately and strongly with EMA; 26.6% weakly, 48.4% moderately and strongly with S-100. Other thyroid lesions were stained 36.5% weakly, 5.8% moderately with CK-19; 26.6% weakly, 15.4% moderately with EMA; 7.7% weakly, 1.9% moderately with S-100. None of the thyroid lesions, but papillary carcinoma, were stained with HBME-1. Papillary carcinoma cases had significantly higher staining with all four markers. However, HBME-1 and CK-19 were considered more valuable in differential diagnosis for papillary carcinomas, since they showed moderate and strong staining. Also high sensitivity and specificity of HBME-1 makes it a good marker for the diagnosis of papillary thyroid cancer.
The Effects of Proton Pump Inhibitors for Dispeptic Complaints in Patients With Nonalcoholic Steatohepatitis
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Kalkan, N.Ö.; Öztürk, M.
As the most common liver disease in recent years, nonalcoholic fatty liver disease (NAFLD) has gained great importance. In recent years, a close relationship with insulin resistance has been shown in the pathogenesis of NAFLD and its severe form, NASH. This study aimed to observe the effects of proton pump inhibitors (PPIs) on insulin resistance and hepatosteatosis by causing hypergastrinemia. Forty-two patients diagnosed with steatohepatitis were included in the study. Seventeen of the 42 patients were followed up with dietary therapy alone, and 25 were followed up with diet+PPI for 2 months due to accompanying dyspeptic complaints. Biochemical and anthropometric measurements of the patients were made before and after the treatment. Levels of the following parameters decreased significantly after treatment in ca ses followed only with diet: total cholesterol (p=0.009), low-density lipoprotein (LDL) (p=0.007), weight (p=0.004), waist circumference (p=0.006), and body mass index (BMI) (p=0.026). Whereas, there was a significant decrease in the levels of alanine tran saminase (ALT) (p=0.005), aspartate transaminase (AST) (p=0.009), total cholesterol (p=0.020), low-density lipoprotein (LDL) (p=0.031), and waist circumference (p=0.008) after treatment with diet+PPI. After two months, the increase in the mean insulin resistance levels (HOMA-IR) in the diet group was significantly higher than the increase of mean HOMA-IR levels in the diet+PPI group (p=0.02). In conclusion, a significant improvement in liver enzymes was observed in patients with Nonalcoholic steatohepatitis with 2 months of pantoprazole treatment added to dietary management. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effects of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Low-Dose Acetylsalicylic Acid on Radiolucent Gallstones
(2003) Tuncer, I.; Harman, M.; Mercan, R.; Öztürk, M.; Arslan, I.; Meral, C.; Türkdoǧan, M.K.
Background/aims: Mucin, a high molecular weight glycoprotein secreted by the gallbladder and biliary duct epithelium, is a pronucleating agent in experimental and human gallstone disease. Blockage of mucin release with aspirin inhibits the formation of primary gallstones in animal models. The aim of this study was to compare the effects of ursodeoxycholic acid alone and plus low-dose aspirin on dissolution of solitary or multiple gallstones. Methods: There were three treatment groups comprising 43 patients with cholesterol gallstones: Group I (n=16, 13 females, three males) was givenursodeoxycholic acid (15 mg. kg. day) alone and Group II (n=14, 12 females, two males) was treated with aspirin (100 mg/day) in addition to ursodeoxycholic acid cholic. Group III was a control group of 13 cases (11 females, two males) who were monitored without medical treatment. Stone dissolution rates were evaluated sonographically in all patients at three month intervals during the treatment period. Results: After 12 months of treatment, stone dissolution was found in six (37.5%) of the patients in Group I and six (42.8%) of the patients in Group II. The difference in both treatment groups was significant compared to controls (p<0.05) but there was no significant difference between the two treatment groups (p>0.05). Of the cases in whom dissolution was achieved, all patients had multiple gallstones except for one with a solitary stone in Group I. Gallstones were not dissolved of any subject of group III. Conclusions: The results showed that ursodeoxycholic acid cholic therapy is more effective in the dissolution of multiple gallstones than of solitary ones. Combination with aspirin did not potentiate the efficacy of ursodeoxycholic acid cholic.
Hypoglycemic and Hepatoprotective Effects of Foeniculum Vulgare Miller Seed Fixed Oil Extract in Mice and Rats
(2003) Özbek, H.; Öztürk, M.; Bayram, I.; Uǧraş, S.; Çitoǧlu, G.S.
Objective: We aimed to investigate median lethal dose (LD50) and hypoglycemic effect of fixed oil of Foeniculum vulgare Miller seed fixed oil (FFO) in mice and its hepatoprotective effect on carbon tetrachloride (CCl4) induced liver injury model in rats. Method: Extract of FFO, glibenclamide (as a reference group) and physiologic saline (control group) were administrated to the healthy and diabet occured mice with alloxan. Before treatment in the first, second, third, fourth and 24th hours, blood was taken from the vena coccygea of mice. Blood glucose levels were measured. Twenty-four Sprague-Dawley rats were divided into four groups (n=6), and the groups treated daily for seven days, by i.p. injections, of isotonic saline solution (ISS), olive oil, carbon tetrachloride (CCl4), CCl 4 + FFO respectively. Results: FFO did not significantly reduced blood glucose in alloxane-induced diabetic mice compared to ISS control group. In contrast, glibenclamide effectively reduced blood glucose of alloxane-induced mice in first, second, fourth and 24th hours as expected. In the CCl4-treated group and FFO-treated group serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels were quite high. In contrast, the control groups (group I and group II) had significantly lower levels of AST and ALT when compared with the CCl4 and FFO groups. Conclusion: The results of this study indicate that FFO has neither a potent hepatoprotective effect against CCl4-induced hepatic damage in rats nor a hypoglycemic action in mice. The LD50 of FFO was determined as 5.52 mL/kg.
Pilomatriksoma
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2018) Isa, A.N.; Öztürk, M.; İBi̇Loğlu, I.
The Presence of Erythropoietin Receptor in Parathyroid Cells
(Editrice Kurtis s.r.l., 2007) Öztürk, M.; Üstek, D.; Akbaş, F.; Kösem, M.; Abaci, N.; Alagöl, F.; Kotan, Ç.
Context: Effects of erythropoietin on parathyroid cell function has not been studied before. Objective: We aimed to demonstrate whether erythropoietin receptor present in parathyroid cells. Design: The specimens of normal parathyroid gland, parathyroid adenoma and hyperplasia were retrieved from our pathology archieves. The sections were stained immunohistochemically. Quantitative gene expression study was performed for erythropoietin and erythropoietin receptor. Results: Erythropoietin receptors were detected by immunohistochemical staining and by its gene expression. Its density was higher in normal parathyroid, followed by parathyroid adenoma and hyperplasia. Conclusion: Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia. © 2007, Editrice Kurtis.
The Relationship Between Calcium Metabolism Parameters
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Yildiz, S.; Öztürk, M.
Blood calcium is under very tight control in a narrow range of 8.5-10.5 mg/dl. We aimed to investigate the factors that contributed to this control. 464 females and 254 males aged 16-96 years were examined retrospectively. PTH, 25OH vitamin D, Ca, Mg, P and spot urine calcium, creatinine levels were examined. The rates were as follow; hypercalcemia 5.6%, primary hyperparathyroidism 10.4%, secondary hyperparathyroidism 40.8%, tertiary hyperparathyroidism 17.5%, normal PTH hypercalcemia 1.25%, hypocalcemia 13.5%, hypoparathyroidism 3.7%, hypovitaminosis D 77.6%, hypophosphatemia 6.4%, hyperphosphatemia 17.5%, hypomagnesemia 17.5%, hypermagnesemia 10.4%. Severe vitamin D deficiency was found as 37% (n= 172) in females and 20% (n= 53) in males (p <0.01). Urinary Ca and urine creatinine 25 OH vitamin D cut-off value was 10 ng/ml and it was 13ng/ml for PTH. While vitamin D was 10-20 ng/ml, urine Ca/creatinine ratio was lowest and it increased after 20 ng/ml in females and 30 ng/ml in males. There was a negative correlation with PTH as Ca decreased from 8.3 mg/dl and a positive correlation when it increased above 9.2 mg/ dl. Mg correlated positively with PTH, Ca and P (p= 0.00 r= 0.23, p= 0.007 r= 0.13, p= 0.00 r= 0.21, respectively). Mg was found to be significantly correlated with all parameters and 25 OH vitamin D was not correlated with any parameters. On the other hand, we have determined the threshold values where the parameters interact with each other. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Tanınız Nedir
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2017) İsa, A.N.; Öztürk, M.; Ibikoglu, I.