Browsing by Author "Üstün, R."

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Effects of Trauma and Cisplatin on Survival in Drg Neurons
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Seker, A.; Üstün, R.
Today, peripheral nerve injuries are one of the clinically critical pathological conditions with a high prevalence and significantly reduce the quality of life of individuals. In peripheral nerve injuries, structural and functional deteriorations of varying rates and reversible or permanent nature are observed in sensory, motor, and autonomic nerve fibers. In peripheral nerve injuries, although the source varies, practical treatment approaches and chemical agents are needed to reverse the pathological processes that develop in the acute and chronic periods. In this study, the effects of trauma and neurotoxicity at the cellular level in the acute period were examined, and the role of these factors in neuronal survival was evaluated. Balb/C strain mice with high regeneration capacity, 6–8 weeks old, were used in the study. In vitro experiments were performed on dorsal root ganglion (DRG) neurons isolated from these animals. Three groups were formed in the experimental design: The control group, the axotomy (trauma) group, and the cisplatin-treated neurotoxicity group. According to the obtained data, it was observed that the traumatic effect modeled with the axotomy met hod reduced neuronal survival more significantly compared to cisplatin-induced neurotoxicity (p<0.05). These findings indicate that preserving neuronal survival in the acute period is critical in managing nerve injury. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of the Cellular Mechanisms of Actions of Digoxin and Monensin by Using Guinea-Pig Papillary Muscles
(2009) Üstün, R.; Meral, I.
Intensive and dwarfed fruit apple fruit production is getting common for last ten years in Turkey. Modern apple production has brought an important level with the contribution of some private sectors in Karaman, Isparta, Konya, Niǧde and Denizli where apple production is common. It is still not desired level due to improper cultural applications such as irrigation, fertilization and especially in pruning. Among the cultural applications which effect the yield and fruit quality, pruning and training of trees are the most important. Although pruning application is getting common over producers, these applications are still not modern pruning systems as desired. Training and pruning are such a techniques that several factors such rootstock, cultivar, planting density and support systems are need to be considered all together, Among them, pruning is the most important and sophisticated factor. When the producers give enough importance on pruning, they will observe improvements both in yield and fruit quality.
Investigation of the Neuro-Regenerative Effects of Bioresonance and Magnetotherapy in Sciatic Nerve Damage-Induced Rats
(Universidad de la Frontera, 2023) Tas, A.; Nalci, K.A.; Sincan, S.; Özdemir, H.; Üstün, R.; Aras, I.; Tuncer, M.C.
Peripheral nerve damage is a significant clinical problem that can lead to severe complications in patients. Regarding the regeneration of peripheral nerves, it is crucial to use experimental animals' nerves and use different evaluation methods. Epineural or perineural suturing is the gold standard in treating sciatic nerve injury, but nerve repair is often unsuccessful. This study aimed to investigate the neuroregenerative effects of magnetotherapy and bioresonance in experimental animals with sciatic nerve damage. In this study, 24 female Wistar rats were divided into 7 groups (n=6) as follows: Group 1 (Control), Group 2 (Axonotmesis control), Group 3 (Anastomosis control), Group 4 (Axonotmesis + magnetotherapy), Group 5 (Anastomosis + magnetotherapy), Group 6 (Axonotmesis + bioresonance), Group 7 (Anastomosis + bioresonance). Magnetotherapy and bioresonance treatments were applied for 12 weeks. Behavioural tests and EMG tests were performed at the end of the 12th week. Then the rats were sacrificed, and a histopathological evaluation was made. The statistical significance level was taken as 5% in the calculations, and the SPSS (IBM SPSS for Windows, ver.21) statistical package program was used for the calculations. Statistically significant results were obtained in animal behaviour tests, EMG, and pathology groups treated with magnetotherapy. There was no statistically significant difference in the groups treated with bioresonance treatment compared to the control groups. Muscle activity and nerve repair occurred in experimental animals with acute peripheral nerve damage due to 12 weeks of magnetotherapy, and further studies should support these results. © 2023, Universidad de la Frontera. All rights reserved.