Browsing by Author "Üstün, Y"

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Association of Fibrinogen and C-Reactive Protein With Severity of Preeclampsia
(Elsevier Ireland Ltd, 2005) Üstün, Y; Engin-Üstün, Y; Kamaci, M
Objective: The aim of this study was to determine the levels of plasma fibrinogen and C-reactive protein (CRP) in preeclampsia and their association with the severity of the disease. Study design: CRP and plasma levels of fibrinogen were investigated in 26 cases of normal pregnant women, 26 cases with mild preeclampsia and 26 cases with severe preeclampsia in the third trimester of pregnancy. Mean arterial pressure (MAP) was used as an indicator of the severity of the disease. Analysis of variance with the Kruskal-Wallis test was used when three groups were compared. For correlations, Spearman's rank correlation tests were used. A receiver operating characteristic curve was constructed to evaluate the sensitivity and specificity of CRP. Results: Plasma CRP and fibrinogen levels in mild and severe preeclampsia patients were markedly higher than that of normal third trimester pregnant women. There were significant correlations between MAP and CRP (r = 0.515, p = 0.0001) and MAP and fibrinogen parameters (r = 0.383, p = 6.005) in pregnancies complicated with preeclampsia. Conclusion: We found higher levels of fibrinogen and CRP and presence of good correlation between CRP and MAP in preeclampsia. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Maternal Serum Ceruloplasmin in Preectampsia
(Wiley, 2005) Engin-Üstün, Y; Üstün, Y; Kamaci, M; Sekeroglu, R
Microalbuminuria in Hodgkin's Disease
(Wiley, 2005) Dilek, I; Demir, C; Üstün, Y; Erkoç, R
In some malignant disorders, it was reported that urinary albumin excretion (UAE) was correlated with the prognosis and the extent of the disease. In this study, 24-h UAE was determined in 34 Hodgkin's disease patients without prior treatment and 19 healthy controls. Microalbuminuria (MAU) was defined as UAE >= 20 mu g/min. In patients with MAU, UAE was determined again after the treatment. Mean UAE was 31.2 mu g/min in the patient group and 5.6 mu g/min in the controls (p = 0.005). Whereas MAU frequency was 47% in the patients, there was no MAU in the controls. Mean UAE tended to be higher in advanced stage patients compared to early stage patients (p = 0.051). Also, MAU frequency tended to be higher in the advanced stage group compared to the early stage group (p = 0.196). In four patients in whom remission could not have been achieved, although UAE was reduced, MAU did not disappear. In conclusion, UAE was increased in Hodgkin's disease. However, there is no significant correlation between UAE and the disease extent.
Placental and Cord Malondialdehyde and Maternal and Perinatal Outcomes
(Wiley, 2004) Zeteroglu, S; Üstün, Y; Üstün, YE
Raynaud's Phenomenon in a Healthy Turkish Population
(Springer London Ltd, 2005) Onbasi, K; Sahin, I; Onbasi, O; Üstün, Y; Koca, D
Raynaud's phenomenon (RP) is a vasospastic disease and is characterized by ischemia of the digits, nose, and ears. The vasospasm can be triggered by cold weather, cold water, or emotional stress and is followed by triphasic color changes. First white color (ischemia), then blue color (congestion and cyanosis), and finally red color change (reactive hyperemia) can be observed. The prevalence is reported to be between 0.5 and 20% in different studies and is dependent on genetic, occupational, and environmental factors. The purpose of our study was to determine the prevalence of RP in an eastern part of Turkey among healthy subjects. A total of 768 people were included in the study. This cross-sectional study was conducted between April 2003 and October 2003 at the University Hospital and at the State Hospital in Van, Turkey. The participants were interviewed and examined to diagnose RP and a questionnaire and color charts were used. Of these 768 patients, 25 women and 20 men were diagnosed to have RP. A female predominance (25/20) was observed. Their mean age was 24.78 +/- 5.71 years. The prevalence of RP was 5.9% in our study population.
Trace Element Status in Plasma and Erythrocytes in Hyperemesis Gravidarum
(Sci Printers & Publ inc, 2004) Dökmeci, F; Engin-Üstün, Y; Üstün, Y; Kavas, GÖ; Kocatürk, PA
OBJECTIVE: To determine trace clement status in plasma and erythrocytes hyperemetic women at presentation and after treatment. STUDY DESIGN: Studies were carried out on 32 women with hyperemesis gravidarum. Thirteen no"vomiting, healthy, pregnant women served as controls. Copper, zinc and magnesium concentrations in both plasma and erythrocytes were estimated before and after treatment. Independent sample t test, paired sample t test, Wilcoxon signed rank test, Mann-Whitney U test, chi(2) test, Kruskall-Wallis one-way analysis of variance and Spearman's correlation study were used for statistical analysis. RESULTS: There were no significant differences between the 2 groups in erythrocyte zinc, copper and magnesium concentration. Plasma zinc levels were significantly higher (P = .006), while plasma copper levels were significantly lower (P = .001) in the study group as compared to the controls, but plasma magnesium levels were not significantly altered. Treatment brought a significant decrease in plasma zinc levels (P = .001), increase in plasma copper concentration (P = .001) but no change in ery-throcyte zinc, copper or magnesium concentration. When trace element levels were grouped according to the degree of ketonuria, no significant differences were found in the 2 groups. CONCLUSION: Hyperemetic women had normal tissue zinc, copper and magnesium concentrations, and rehydration normalized the plasma zinc and copper levels. Otherwise, no significant effects on trace elements were noted.