Browsing by Author "Üstün, Y."

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Association of Maternal Obesity and Fetal Gender With Preeclampsia
(2003) Üstün, Y.; Engin Üstün, Y.; Zeteroǧlu, Ş.; Şahin, G.; Kamaci, M.
OBJECTIVE: To evaluate the role of maternal obesity and fetal gender in the pathoge-nesis of preeclampsia and to determine the fetal gender ratio and difference of body mass index in normal and preeclamptic group. STUDY DESIGN: In a prospective study design, in one year period, one of every 10 normal pregnancies (n=59) and all preeclamptic pregnancies were enrolled into the study (n=42). Clinical characteristics recorded included maternal age, body mass index, gravidity, parity, estimated gestational age, mode of delivery, neonatal birth weight, and fetal gender. RESULT(s): There were no statistically significant differences in maternal age, gravidity and parity between the groups. Body mass index was significantly higher in preeclamptic group (p=0.001) but no difference was found in fetal gender between the groups. CONCLUSION(s): Maternal obesity has a probable role in the pathophysiology of preeclampsia but fetal gender seems to play no role.
Calcium Antagonists
(2000) Şahin, I.; Onbaşi, K.; Şahin, H.A.; Onbaşi, O.; Üstün, Y.
Calcium antagonists are a heterogeneous group of drugs which block the entry of calcium into the smooth muscle, resulting in vasodilation. They are used for the treatment of hypertension, angina pectoris, supraventricular tachycardia, atrial fibrillation and flutter, subarachnoid hemorrhage. Also they can be used for the treatment of biliary and intestinal colic, migraine, esophageal spasm, preterm labor, left ventricular diastolic dysfunction, Raynaud's phenomenon, and bipolar disorders. These drugs can be divided into three groups: The dihydropyridine group (nifedipine, nitrendipine, nisoldipine, nicardipine, isradipine, felodipine, amlodipine, lacidipine, nimodipine), phenylalkylamine group (verapamil) and the benzothiazepine group (diltiazem). They can also be used in the elderly patients and patients with COPD, diabetes, renal insuffiency, gout, hyperlipidemia with safety. The short acting group has been shown to increase the risc of myocardial infarction. For this reason, the long-acting drugs have been shown to be more safe. Calcium antagonists have a broad indication spectrum of usage for therapy of several diseases.
Comparison of Presence of Autoimmune Activity in Patients With Premature Ovarian Failure and Menopause
(2003) Engin-Üstün, Y.; Üstün, Y.; Iltemir, C.; Demirel, L.C.; Kurtay, G.
Objective: To assess and compare autoimmune activity in patients with premature ovarian failure (POF) and menopause. Method: Thirteen women with premature ovarian failure but with no history of autoimmune disease were recruited into the study group and 15 women with natural menopause into control group between January 1999 and November 2000. The mean FSH levels of patients with premature ovarian failure were 73.95±29.11 (range: 41-130.7 U/L). Nuclear (antinuclear antibody=ANA, double-stranded DNA antibody=anti-dsDNA) and cardiolipin antibodies (IgM, IgG), immunoglobulins (IgM, IgG, IgA) and complement (C3, C4) levels were determined. Student's t test was used to compare the groups. Results: Antinuclear antibody was positive in 30.7% of patients with premature ovarian failure and in 13.3% of controls. There was no significant difference in anticardiolipin antibodies, immunoglobulins and complement levels between the groups (p>0.05). Conclusion: In our study, no autoimmune deficiency was found in patients with POF.
Placental Pathologic Features in Preeclampsia and Normal Pregnancies
(2005) Engin Üstün, Y.; Üstün, Y.; Zeteroǧlu, Ş.; Güvercinci, M.; Kamaci, M.; Uǧraş, S.
AIM: The objective was to evaluate placental pathologic features in normal and preeclamptic pregnancies. STUDY DESING: Eighty-three preeclamptic-eclamptic and 30 control pregnant women without systemic disease between October 2001 and September 2002 were prospectively recruited. Placental pathologies were evaluated due to macroscopic findings and nine histological parameters on light microscope. Statistics included student t test and chi-square test. RESULT(s): Increased syncytiotrophoblast knotting, cytotrophoblast proliferation, focal perivillous fibrin deposition, villous stromal fibrosis, fibrinoid necrosis, maturation, basal membrane thickening, mineralization in basal membrane and villous stromal edema were more common in the study group compared to the control group. Fibrinoid necrosis in uteroplacental vessels, villous stromal fibrosis, mineralization in basal membrane and villous stromal edema were not seen in any patient in the control group. CONCLUSION: Placental pathologic features play an important role in the pathophysiology of preeclampsia.
Raynaud's Phenomenon in Healthy Population Who Admitted To the Hospital in Van Region, Turkey
(2003) Şahin, I.; Onbaşi, K.T.; Onbaşi, O.; Üstün, Y.; Mercan, R.; Şahin, H.A.; Görpelioǧlu, S.
Raynaud's phenomenon is a vasospastic disease and is characterized with ischemia of the digits, nose and ears. The vasospasm can be triggered by cold weather, cold water or emotional stress and is followed by triphasic color changes. First white color (ischemia), than blue color (congestion and cyanosis) and at last red color change (reactive hyperemia) can be observed. The prevalence is reported between 0,5 to 20 percent in different studies and is dependent on genetic, occupational, and environmental factors. The purpose of our study was to determine the prevalence of RP in a eastern part of Turkey among healthy subjects. A total of 251 people were included to the study. This cross-sectional study was conducted between April 2000 and July 2000 at the University Hospital and at the State Hospital in Van, Turkey. The participants were interviewed and examined to diagnose RP and a questionnaire and color charts were used. A total of 251 (134 women (53.4%), 117 men (46.6%)) subjects participated in this study. The overall mean age was 28.93±11.15. Definite RP was detected in 10 subjects according to at least two color changes (3.98%). They consisted of 6 women and 4 men. Mean age was 23.5±5.38. Four patients responded positively two color changes and six patients for three color changes. All patients who had symptoms had told their symptoms appeared in both hands. Probable RP was diagnosed in 20 patients with only one color change (7.96%). Mean age was 27.05±11.01 in probable RP group. Only 11 of 30 patients applied to any medical unit for RP (36.6%). The prevalence of RF was less found than literature perhaps it can be said that there is a strong influence of the climate in comparison to other contributing factors.
Tension-Free Vaginal Tape Compared With Laparoscopic Burch Urethropexy
(Journal of the American Assoc. of Gynecologic Laparoscopists, 2003) Üstün, Y.; Engin-Üstün, Y.; Güngör, M.; Tezcan, S.
Study Objective. To compare laparoscopic Burch colposuspension and tension-free vaginal tape (TVT) procedure in women with genuine stress incontinence. Design. Randomized clinical study (Canadian Task Force classification I). Setting. Tertiary care university hospital. Patients. Forty-six consecutive women. Intervention. Laparoscopic Burch colposuspension (23) and TVT procedure (23). Measurements and Main Results. Valsalva leak-point pressure increased after surgery in both groups, but TVT substantially decreased maximum urinary flow rate. Other urodynamic studies showed no statistical differences. The groups did not differ significantly with respect to intraoperative complications or objective and subjective cure rates. Operating time was significantly longer for laparoscopic Burch (p = 0.001), and three patients in that group required conversion to laparotomy. Length of hospital stay (p = 0.003) and duration of catheterization (p = 0.003) were shorter in the TVT group. Conclusion. TVT holds promise in women with genuine stress incontinence, with several advantages over laparoscopic Burch.