Browsing by Author "Şipal, A."

Now showing 1 - 2 of 2

Containment Measures Established During the Covid-19 Outbreak and Its Impact on Lipid Profile and Neutrophil To Lymphocyte Ratio
(Verduci Editore s.r.l, 2020) Aladağ, N.; Şipal, A.; Atabey, R.D.; Akbulut, T.; Asoğlu, R.; Özdemir, M.
OBJECTIVE: Almost all countries announced social restrictions and distancing measures which could unintentionally lead to a decline in admissions to hospital for acute disorders other than signs of pneumonia. We aimed to evaluate lipid profile, neutrophil to lymphocyte ratio (NLR) and cardiovascular admissions to the coronary care unit (CCU) of a tertiary center in Turkey during the COVID-19 era and to compare these results with admissions in the same time interval of the previous year. MATERIALS AND METHODS: We retrospectively analyzed CCU admissions due to new-onset atrial fibrillation, ST-elevation myocardial infarction, non-ST elevation acute coronary syndrome (NSTEACS) and acute heart failure during the COVID-19 outbreak and the same time interval of the past year. Laboratory measurements including lipid profile and NLR values were retrieved from the institutional digital database. RESULTS: Compared to the same time interval of 2019 (March-April, 2019), the number of patients admitted to the CCU with acute cardiovascular disorders (atrial fibrillation, STEMI, NSTEACS and acute heart failure) were lower in the COVID-19 period. The levels of NLR, total cholesterol, and low-density lipoprotein (LDL) cholesterol were significantly higher and high-density lipoprotein (HDL) cholesterol was significantly lower in subjects admitted to the CCU during March-April 2020 compared to subjects admitted in March-April 2019. CONCLUSIONS: Our findings show that subjects admitted to the CCU in the COVID-19 era have an unfavorable lipid profile and elevated NLR compared to those admitted in 2019. These patients appear to be at high risk for future cardiovascular events. © 2020 Verduci Editore s.r.l. All rights reserved.
Low Superoxide Dismutase and Catalase Is Associated Malondialdehyde and Ischemia Modified Albumin in Patients With Non-St Elevated Myocardial Infarction (Nstemi)
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Aladağ, N.; Şipal, A.
Non-ST elevated myocardial infarction (NSTEMI) diagnosis is difficult when the electrocardiography (ECG) normal and troponin parameters are slightly higher than the normal reference range. This study aimed to assess the IMA (ischemia modified albumin), MDA (malondialdehyde), SOD (superoxide dismutase), and catalase in patients with NSTEMI. The present study included 55 patients with NSTEMI and 55 healthy subjects prospectively. IMA, MDA, SOD, and catalase levels were measured from venous blood obtained from each patient within twelve hours after the onset of symptoms. Differences between the two groups were evaluated with Student's unpaired t-test for parameters with a normal distribution. IMA (3.14 ± 0.06 vs. 1.49 ± 0.03) and MDA (3.14 ± 0.06 vs. 1.49 ± 0.03) were higher, and SOD (1.10 ± 0.03 vs. 2.31 ± 0.02) and catalase (0.54 ± 0.02) vs. 0.22 ± 0.02) were lower in NSTEMI patients than control subjects. There was a significant correlation among IMA, MDA, SOD and catalase. Our data reveal that levels of MDA and IMA were increased, and SOD and catalase levels were decreased significantly in patients with NSTEMI. Blood concentrations of oxidant and antioxidant parameters could assess the oxidative state in patients with NSTEMI. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.