Browsing by Author "Aşkin, R."

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Factors Associated With Quality of Life in Obsessive Compulsive Disorder
(Cukurova University, Faculty of Medicine, 2007) Beşiroǧlu, L.; Uǧuz, F.; Saǧlam, M.; Yilmaz, E.; Aǧargün, M.Y.; Aşkin, R.
Objective: Since obsessive compulsive disorder (OCD) is an illness that considerably influences the family, academic, occupational and social functioning of patients, the relationship between OCD and QOL has been acquiring more importance. The present study was designed to investigate which aspects of quality of life (QOL) are most affected in OCD and to explore the predictors of decreased QOL in OCD. Methods: Seventy three patients with OCD and 69 healthy control subjects were compared in terms of their quality of life scores by means of WHOQOL-BRIEF. The relationship between QOL and probable clinical variables were explored by means of multivariate regression analyses. Results: Psychological health and social relationship scores of OCD patients were significantly lower than healthy subjects. Multivariate regression analyses revealed that the severity of depressive symptoms was the best predictor of both psychical health, and psychological health. The presence of comorbid personality disorder was the second significant factor to predict psychological health. While the severity of compulsions was the sole associated factor with psychological health, in second model, severity of depression as an associated variable was added to equation. Only the duration of illness was associated with environment scores. In the bivariate correlational analyses, while the severity of obsessions and depressive symptoms were significantly associated with psychological health, there is no association between psychological health and compulsion severity. Discussion: Since the subjective perception of QOL is considerably affected by depression severity, a quality of life assessment instrument that is specific for OCD should be developed.
Psychopharmacological Treatment Response in Obsessive Compulsive Patients With Autogenous and Reactive Obsessions
(2007) Beşiroǧlu, L.; Uǧuz, F.; Saǧlam, M.; Aǧargün, M.Y.; Aşkin, R.; Çilli, A.S.
Objective: It has been suggested that obsessions related with different cognitive process can be discriminated as autogenous and reactive obsessions. This study aimed to compare treatment response to psychopharmacological interventions of the OCD patients with autogenous and reactive obsessions. Methods: Using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale (HDRS) and White Bear Suppression Inventory we assessed 20 patients with auotogenous obsessions (Autogenous group, AG) and 22 patients with reactive obsessions (Reactive group, RG) who met the DSM-IV criteria for OCD. The patients were consecutively assigned to receive either sertraline (100-200 mg/day), fluvoxamine (200-300 mg/day) or paroxetine (40-80 mg/day). We reassessed 80% of the initial AG (n=16) and 68% of initial RG (n=15) after 12 weeks. Results: The YBOCS obsession, compulsion, total scores, HDRS and WBSI scores at follow-up in both AG and RG were significantly lower than at baseline scores. The mean differences from baseline to follow up for obsession severity and suppression tendency in the AG were significantly higher than RG. The relationships between mean differences from baseline to follow up assessments on severity of obsessions, depressive symptoms and suppression tendency were found to be significant in the AG. Mean difference from baseline to follow up assessments on severity of obsessions were significantly associated with mean difference for compulsion severity in the RG. Conclusions: Discrimination for obsessions based on autogenous versus reactive may have implications for identifying psychopathological mechanisms implicated in the OCD, and for understanding variability in treatment response.
Sociodemographic and Clinical Characteristics in Patients With Obsessive-Compulsive Disorder With and Without Comorbid Obsessive-Compulsive Personality Disorder
(2009) Uǧuz, F.; Beşiroǧlu, L.; Aşkin, R.
Objective: In this study, we aimed to investigate sociodemographic and clinical characteristics in patients with obsessive-compulsive disorder (OCD) with and without comorbid obsessive-compulsive personality disorder (OCPD). Methods: This study was conducted among patients who were admitted to outpatients clinics of department of psychiatry of 2 different university hospitals. The study sample consisted of 30 OCD outpatients with only OCPD among the Axis II disorders and 38 OCD patients without any Axis II disorders. Axis I and Axis II psychiatric disorders were determined by means of the Structured Clinical Interview for DSM-IV/ Clinical Version (SCID-I/CV) and the Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II), respectively. The Yale-Brown. Obsessive-Compulsive Scale (Y-BOCS) was used to determine types and severity of obsessive-compulsive symptoms. The patients' insight degree on obsessive-compulsive symptoms was assessed by means of the item 11 on the Y-BOCS. Results: The study groups had similar characteristics with respect to age, sex, educational level, marital status, and employment status. Compared to OCD patients without OCPD, symmetry/exactness obsessions, ordering/arranging compulsions, and diagnoses of comorbid major depression, dysthymic disorder, generalized anxiety disorder and social phobia were found to be significantly more frequent in OCD patients with OCPD. There was no significant difference between study groups in terms of other types and severity of obsessive-compulsive symptoms, other comorbid axis I disorders, age at onset and duration of OCD, and the patients' insight degree. Conclusion: The study results suggest that OCD patients with and without comorbid OCPD have generally similar sociodemographic and clinical characteristics.