Browsing by Author "Aǧargün, M.Y."

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Characteristics of Patients With Nocturnal Dissociative Disorders
(2001) Aǧargün, M.Y.; Kara, H.; Özer, O.A.; Semiz, U.; Selvi, Y.; Kiran, U.; Tombul, T.
Frequency of nocturnal dissociative episodes (NDE) in patients with dissociative disorders (DD) was determined and clinical characteristics of patients with nocturnal dissociative disorders was compared with those DD only. Extensive overnight polysomnographic monitoring with nocturnal video-polysomnography was performed in 8 patients with NDE and 21 patients with DD only. We found a 27.5% prevalence of NDE in patients with DD. A clear transition from one personality to another was observed during sleep in 2 (about 7%) patients. Hallucinations, self-mutilating behaviors during sleep, and violent behavior during sleep were more common in the patients with NDE. Sleep may facilitate the transition from one personality to the other one. Patients with DD may use dissociation as a defense mechanism during sleep.
Factors Associated With Quality of Life in Obsessive Compulsive Disorder
(Cukurova University, Faculty of Medicine, 2007) Beşiroǧlu, L.; Uǧuz, F.; Saǧlam, M.; Yilmaz, E.; Aǧargün, M.Y.; Aşkin, R.
Objective: Since obsessive compulsive disorder (OCD) is an illness that considerably influences the family, academic, occupational and social functioning of patients, the relationship between OCD and QOL has been acquiring more importance. The present study was designed to investigate which aspects of quality of life (QOL) are most affected in OCD and to explore the predictors of decreased QOL in OCD. Methods: Seventy three patients with OCD and 69 healthy control subjects were compared in terms of their quality of life scores by means of WHOQOL-BRIEF. The relationship between QOL and probable clinical variables were explored by means of multivariate regression analyses. Results: Psychological health and social relationship scores of OCD patients were significantly lower than healthy subjects. Multivariate regression analyses revealed that the severity of depressive symptoms was the best predictor of both psychical health, and psychological health. The presence of comorbid personality disorder was the second significant factor to predict psychological health. While the severity of compulsions was the sole associated factor with psychological health, in second model, severity of depression as an associated variable was added to equation. Only the duration of illness was associated with environment scores. In the bivariate correlational analyses, while the severity of obsessions and depressive symptoms were significantly associated with psychological health, there is no association between psychological health and compulsion severity. Discussion: Since the subjective perception of QOL is considerably affected by depression severity, a quality of life assessment instrument that is specific for OCD should be developed.
High Cholesterol Levels in Patients With Sleep Panic
(1996) Aǧargün, M.Y.; Kara, H.; Algün, E.; Şekeroglu, R.; Tarakçioǧlu, M.
Hypnotic Intervention for Pain Management in a Child With Sickle Cell Anemia
(2001) Aǧargün, M.Y.; Öner, A.F.; Akbayram, S.
Imipramine Treatment of Panic Disorder Patients With Frequent Sleep Panic
(1999) Aǧargün, M.Y.; Kara, H.; Çilli, A.S.
Objective: The aim of this study was to examine the effectiveness of imipramine treatment in the panic disorder patients who had frequent sleep panic attacks as predominant clinical features. Method: Thirteen patients whose sleep panic attacks represented their primary complaint at the time of admission were given imipramine for an 8-week trial. Results: 150 mg/day imipramine treatment reduced the frequency and the severity of sleep panic attacks in patients. Conclusions: These findings suggest that imipramine is useful in the treatment of this subgroup patients of panic disorder.
Invited Comment
(2002) Aǧargün, M.Y.
The Psychometric Properties of the Clark-Beck Obsessive-Compulsive Inventory in a Turkish Population
(2007) Beşiroǧlu, L.; Aǧargün, M.Y.; Boysan, M.; Güleç, M.; Eryonucu, B.
Objective: We examined the psychometric properties of the Clark-Beck Obsessions and Compulsions Inventory eveloped to assess the frequency and severity of obsessive compulsive symptoms. Methods: The sample consisted of 52 OCD patients, 32 non-OCD patients with other anxiety disorders, 36 nonobsessional depressed patients, 75 healthy adults, and 278 undergraduate students. We investigated internal consistency, test-retest reliability, concurrent and discriminant validity of the instrument. Results: Cronbach's α coefficients for the CBOCI Obsessions, Compulsions and Total scale were found as 0.86, 0.83 and 0.91 in all samples respectively. The CBOCI obsessions (r=0.81, p<0.001), compulsions (r=0.85, p<0.001) and total score (r=0.85, p<0.001) showed a significant level of temporal stability. OCD patients scored significantly higher on CBOCI obsessions, compulsions and total scale than non-obsessional anxious, depressed patients, healthy control subjects. Obsession, compulsion and total scores of both OCD and nonclinical sample were significantly correlated with other scales assessing obsessive compulsive symptoms. Discussion: The Turkish version of the CBOCI has appropriate reliability and validity for assessing the frequency and severity of obsessive-compulsive symptoms.
Psychopharmacological Treatment Response in Obsessive Compulsive Patients With Autogenous and Reactive Obsessions
(2007) Beşiroǧlu, L.; Uǧuz, F.; Saǧlam, M.; Aǧargün, M.Y.; Aşkin, R.; Çilli, A.S.
Objective: It has been suggested that obsessions related with different cognitive process can be discriminated as autogenous and reactive obsessions. This study aimed to compare treatment response to psychopharmacological interventions of the OCD patients with autogenous and reactive obsessions. Methods: Using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Hamilton Depression Rating Scale (HDRS) and White Bear Suppression Inventory we assessed 20 patients with auotogenous obsessions (Autogenous group, AG) and 22 patients with reactive obsessions (Reactive group, RG) who met the DSM-IV criteria for OCD. The patients were consecutively assigned to receive either sertraline (100-200 mg/day), fluvoxamine (200-300 mg/day) or paroxetine (40-80 mg/day). We reassessed 80% of the initial AG (n=16) and 68% of initial RG (n=15) after 12 weeks. Results: The YBOCS obsession, compulsion, total scores, HDRS and WBSI scores at follow-up in both AG and RG were significantly lower than at baseline scores. The mean differences from baseline to follow up for obsession severity and suppression tendency in the AG were significantly higher than RG. The relationships between mean differences from baseline to follow up assessments on severity of obsessions, depressive symptoms and suppression tendency were found to be significant in the AG. Mean difference from baseline to follow up assessments on severity of obsessions were significantly associated with mean difference for compulsion severity in the RG. Conclusions: Discrimination for obsessions based on autogenous versus reactive may have implications for identifying psychopathological mechanisms implicated in the OCD, and for understanding variability in treatment response.
Recurrent Sleep Panic, Insomnia, and Suicidal Behavior in Patients With Panic Disorder
(W.B. Saunders, 1998) Aǧargün, M.Y.; Kara, H.
The purpose of this study was to examine the association between recurrent sleep, panic, and suicidal behavior in panic disorder. We compared the recurrent sleep panickers (N = 33) with other panickers (N = 34). The Schedule for Affective Disorders and Schizophrenia (SADS) suicide subscale was used to rate the severity of active suicidality. We found that recurrent sleep panickers also had a higher percentage of insomnia and comorbid major depression than the others. A multivariate analysis demonstrated an association between recurrent sleep panic and suicidal tendencies in patients with panic disorder. Although recurrent sleep panic alone is not an independent risk factor for suicidal behavior, it may modify the severity of illness in patients with panic disorder.
Repetitive and Frightening Dreams and Suicidal Behavior in Patients With Major Depression
(W.B. Saunders, 1998) Aǧargün, M.Y.; Çilli, A.S.; Kara, H.; Tarhan, N.; Kincir, F.; Öz, H.
The purpose of the present study was to examine the association between repetitive and frightening dreams and suicidal tendency in patients with major depression. Depressed patients who reported frequent nightmare (N = 29) and depressed patients who reported dreaming but never nightmares (N = 34) were evaluated using the Schedule for Affective Disorders and Schizophrenia (SADS) suicide subscale to rate the severity of active suicidality. The patients with frequent nightmares, particularly women, had higher mean SADS suicide subscale scores and were more likely to be classified as suicidal than the others. The findings demonstrate that frequent nightmares are associated with suicidal tendency in patients with major depression. Theoretical and clinical implications for the function of dreaming are discussed.
Sleep Disturbances and Suicidal Behavior in Patients With Major Depression
(Physicians Postgraduate Press Inc., 1997) Aǧargün, M.Y.; Kara, H.; Solmaz, M.
Background: The purpose of this study was to examine the association between sleep disturbances and suicidal behavior in patients with major depression (N = 113). Method: The sleep symptomatology of each patient was ascertained from the Schedule for Affective Disorders and Schizophrenia (SADS) questions concerning sleep were retrospectively classified as having hypersomnia (N = 20), insomnia (N = 69), and no sleep disturbance (N = 24). The SADS suicide subscale was used to rate the severity of active suicidality. Results: The patients with hypersomnia and insomnia had significantly (p < .05) higher scores on the SADS suicide subscale than those without sleep disturbance. We also found that the patients with insomnia and hypersomnia were significantly (p < .001) more likely to become suicidal than the others. Conclusion: These data demonstrate that both insomnia and hypersomnia are associated with suicidal behavior in patients with major depression.
Sleep Quality and Pain Threshold in Patients With Fibromyalgia
(W.B. Saunders, 1999) Aǧargün, M.Y.; Tekeoǧlu, I.; Güneş, A.; Adak, B.; Kara, H.; Ercan, M.
The purpose of the study was to examine the association between the subjective sleep quality and pain threshold in fibromyalgia. Sixteen patients with fibromyalgia were included in the study. The pain threshold was determined using a manual algometer. The Pittsburgh Sleep Quality index (PSQI) was used to assess sleep quality. The pain threshold was negatively correlated with the scores for subjective sleep quality, habitual sleep efficiency, and sleep disturbance and the PSQI global score. We conclude that there is a negative correlation between pain and sleep disturbance: increased pain sensitivity is associated with greater sleep disturbance.
Sleep-Wake Disturbances in Fibromyalgia
(2002) Aǧargün, M.Y.
Fibromyalgia characterized unrefreshing sleep, sleep physiological disturbances, depressed mood, and cognitive difficulties in addition to widespread pain, persisting for at least 3 months, and a minimum of 11 of 18 tender points, tenderness, and other somatic symptoms. Among polysomnographic abnormalities, the most common finding is the intrusion of alpha rhythm into NREM sleep (alpha-delta sleep). Patients with fibromyalgia also exhibit prolonged sleep onset latencies, an increased number of arousal, and increases in stage 1 sleep. However, alpha-delta sleep is not specific or pathognomonic for the diagnosis of fibromyalgia and may represent an epiphenomenon of an undefined central nervous system disturbance. A strong relationship between sleep disturbance and pain perception is clear in fibromyalgia. The interactions among immune system, pain, and sleep disturbance and therapeutic implications are discussed in this article.
Study of Validity and Reliability of the Turkish Version of the Core Bereavement Items
(2011) Selvi, Y.; Öztürk, R.I.; Aǧargün, M.Y.; Beşiroǧlu, L.; Cilli, A.S.
Objective: The aim of this study was to examine the reliability and validity of the Turkish version of the Core Bereavement Items (CBI) that assess the intensities of the bereavement reaction of bereaved individuals. Methods: The study involved 50 bereaved subjects who had lost a loved one through death within the past two months and 50 unbereaved subjects who had not experience such a loss within the past 5 years or more prior to the test. Internal consistency and homogeneity were tested by the Cronbach's and Pearson's correlation coefficients. The student's t-test and Pearson's correlation coefficient were used for rest-retest reliability. Validity was assessed with the student's t-test in independent groups. Results: Psychometric analyses showed that the Turkish version of the CBI had a high internal consistency (α=0.94). As for internal consistency, the · ranged between 0.46 and 0.87 for each item. The items of the CBI discriminated the bereaved group from the unbereaved group, except for items 4, 8, 9, 10. Conclusion: The Turkish version of the CBI has appropriate reliability and validity for assessing the intensity of bereavement. © Archives of Neuropsychiatry.