Browsing by Author "Akbari, Ali"

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Chitosan-Based Ph-Sensitive Antibacterial Bionanocomposites With Laponite Immobilized Silver Nanoparticles for Delivery of Sunitinib Maleate To Breast Cancers
(Wiley, 2024) Labib, Parisa; Mahdavinia, Gholam Reza; Dehghani, Arezoo; Nobarzad, Raoofeh Sattari; Sayyar, Zahra; Jafari, Hessam; Akbari, Ali
In this work, new pH-sensitive and antibacterial drug carrier systems based on silver nanoparticles (AgNPs) embedded in the interlayer of laponite (Lap) in the presence of chitosan (CTS) for the controllable release of sunitinib maleate (STM) were developed. Silver ions and sunitinib maleate were first loaded into Lap, and the CTS-based hybrid bionanocomposite carrier (Lap@CTS@AgNPs@STM) was obtained in the presence of citric acid as a cross-linker agent. The successful preparation of nanocarrier and Ag NPs formation was thoroughly confirmed using techniques such as FTIR, XRD, TGA, SEM, and TEM. TEM images illustrated the excellent distribution of Ag NPs in the structure of Lap@CTS@AgNPs. The as-prepared samples showed a pH-sensitive anticancer drug release behavior. The STM release mechanism was studied using Korsmeyer-Peppas and Higuchi kinetic models. Furthermore, the in vitro cytotoxicity and antibacterial tests were carried out against both bacteria S. aureus and E. coli and MCF-7 cell lines, respectively, to prove the effectiveness of synthesized samples as multifunctional carrier systems for biomedical applications. An effective pH-sensitive antibacterial single nanoformulation based on chitosan with laponite incorporated silver nanoparticles for anticancer drug delivery to the breast cancer was successfully developed. image
Cytotoxicity and Antibacterial Activity of Polyhedral Oligomeric Silsesquioxane Modified Ti3c2tx Mxene Films
(Nature Portfolio, 2025) Akinay, Yuksel; Karatas, Erkan; Ruzgar, Damla; Akbari, Ali; Baskin, Dilges; Cetin, Tayfun; Topuz, Mehmet
Bioactive antimicrobial films play important roles in various fields, such as biodegradable interfaces, tissue regeneration, and biomedical applications where preventing infection, biocompatibility, and immune rejection are important. In the present study, bioactive POSS-doped Ti3C2Tx MXene filled PLA composite film was prepared using the solution casting method for biomedical applications. The contact angle tests were investigated to reveal the usability of the thin films in biomedical applications. The angle decreased from 85.92 degrees degrees in pure PLA thin films to 72.23 degrees on POSS-doped Ti3C2Tx MXene films. The antibacterial performance, cytotoxicity and cell viability assessments of the prepared films have also been thoroughly investigated. Antibacterial tests revealed that the POSS-doped Ti3C2Tx MXene films effectively inhibited the growth of E. coli and S. aureus by 65.93% and 80.63%, respectively, within 4 h. These inhibition rates were observed as 58.32% and 54.97% for E. coli and S. aureus, respectively, after 24 h. Cytotoxicity assessments demonstrated that PMPs consistently showed higher cell viability due to the combination of POSS and Ti3C2Tx MXene. The obtained results suggest that the POSS-doped Ti3C2Tx MXene film is a promising candidate in cases where bacterial inhibition and high biocompatibility are of critical importance.