Browsing by Author "Akbayram, S."

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Acute Immune Thrombocytopenic Purpura Following Combined Vaccine
(Wiley-blackwell, 2015) Akbayram, S.; Karaman, K.; Akbayram, H. T.; Garipardic, M.; Oner, A. F.
Acute Motor Axonal Neuropathy Cases in Van Region
(Comenius Univ, 2011) Sayin, R.; Tombul, T.; Gulec, T. C.; Anlar, O.; Akbayram, S.; Caksen, H.
Acute motor axonal neuropathy (AMAN) is a form of Guillain Barre Syndrome (GBS) seen in summer months in Northern China to cause epidemics. This form of the disease, which is also sporadically observed in other countries, constitutes less than 5 % of GBS in Western countries. It usually develops with motor findings. No sensory findings are observed. In some of the cases, the severe impairments in tissues improve however slowly and inadequately. In the motor conduction studies of cases with AMAN, motor action potential values are lowered. On needle electromyography (EMG), motor unit potential (MUP) activity is diminished with spontaneous denervation findings. Investigations were conducted on nerve conduction of patients with GBS aged from 1 to 77 years. AMAN was detected in 25 of these patients. In our investigation, AMAN as a GBS variant was detected in 39.7 % of the patients. The conduction velocities of motor nerves were in normal ranges whereas combined muscle action potentials were significantly lower. No F response could be obtained. Although AMAN is a rare variant of GBS and shows different clinical courses, it has been brought under intense scrutiny since there is high prevalence of acute inflammatory neuropathies in our region (Tab. 1, Ref. 7). Full Text in free PDF www.bmj.sk.
Acute Respiratory Distress Syndrome Due To Overdose Desferrioxamine: Report of a Child
(2005) Atas, B.; Caksen, H.; Tuncer, O.; Oner, A.F.; Kirimi, E.; Akbayram, S.
In this article, we present an 18-month-old girl with acute iron poisoning who died from acute respiratory distress syndrome due to overdose of desferrioxamine. Our purpose is to emphasize the importance of close follow-up of children with acute iron poisoning for desferrioxamine toxicity.
An Analysis of Children With Brucellosis Associated With Haemophagocytic Lymphohistiocytosis
(2016) Karaman, K.; Akbayram, S.; Kaba, S.; Karaman, S.; Garipardiç, M.; Aydin, I.; Öner, A.F.
This retrospective study included seven paediatric cases aged from 4 to 14 (10.2±3.4) years with pathologically proved haemophagocytic lymphohistiocytosis from a single institution during 2009 and 2013. Over this time period, 496 patients with brucellosis were diagnosed. None of the patients (3 boys and 4 girls) had a history of any haematologic disorder. All patients had an anamnesis for recently consumed unpasteurised homemade dairy products or had a contact history with sheep and/or cows. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titres were 1: 1280 in seven patients. Blood culture was positive for Brucella melitensis in three patients (42%). Bone marrow cultures were positive for B. melitensis in four patients (57%). Fever was present in all patients (100%) with haemophagocytic lymphohistiocytosis. The other most common symptoms were malaise, myalgia, anorexia, sweating and weight loss. In addition, sweating was observed in five patients, and lymphadenopathy, petechiae, and weight loss were observed in one patient. Hepatomegaly, splenomegaly, and hepatosplenomegaly were found in four (57%), six (85%) and four (57%), patients, respectively. Haemophagocytosis was documented in bone marrow examinations of all children except in two cases. All patients recovered completely, and their peripheral blood counts returned to normal by 2 to 4 weeks after antibiotic treatment of brucellosis.
Brucellosis as a Trigger Agent for Henoch-Schonlein Purpura
(Comenius Univ, 2012) Akgun, C.; Akbayram, S.; Guner, S.; Aktar, F.; Temel, H.; Basaranoglu, M.
Vasculitis in childhood is a result of a spectrum of causes ranging from idiopathic conditions with primary vessel inflammation to syndromes after exposure to recognized antigenic triggers, such as infectious agents and drugs causing hypersensitivity reactions. Henoch-Schonlein purpura (HSP) is the most common vasculitis of childhood. Although there is often a history of a recent or simultaneous upper respiratory tract infection, no consistent causative organism is found. We report an 11-year old boy with HSP and brucellosis and we speculated that brucellosis was the trigger agent for HSP (Ref. 13). Full Text in PDF www.elis.sk.
A Case of Fulminant Varicella Infection With Purpura Fulminans, Hepatitis, and Rhabdomyolysis
(2012) Karadag, A.S.; Bilgili, S.G.; Calka, O.; Çeçen, I.; Akbayram, S.
Varicella zoster virus causes varicella which is a common disease. Generally it is self-limiting, and treatment is often unnecessary, but severe or life-threatening complications are rarely seen. We report a case of fulminant varicella complicating with purpura fulminans, hepatitis, and probable rhabdomyolysis in a previously healthy child.
A Case of Idiopathic Intracranial Hypertension Related With Vesicoureteral Reflux
(2011) Akgün, C.; Taşkin, G.A.; Akbayram, S.; Kaya, A.; Temel, H.; Yuca, S.A.; Çaksen, H.
Pseudotumor cerebri is idiopathic intracranial hypertension. The etiology of this syndrome has not been fully clarified. Excess cerebrospinal fluid production, scarcity of cerebrospinal fluid absorption, intracranial venous pressure elevation, increased intracranial blood volume are all thought to be responsible. The symptoms of the disease may be ordered according to prevalence as follows: headache due to increased intracranial pressure, blurred vision and diplopia. A thirteen-year-old female patient was brought in with complaints of headache, double and blurred vision. Systemic arterial hypertension (140/70 mmHg) was determined. Vesicoureteral reflux was detected as the hypertension etiology. In this article a rare pseudotumor cerebri case is presented secondary to vesicoureteral reflux which caused hypertension.
A Case of Langerhans Cell Histiocytosis With Anal Fistula
(Kurume University School of Medicine, 2010) Akbayram, S.; Akgun, C.; Ozen, S.; Kaya, A.; Tuncer, O.; Yuca, S.A.; Oner, A.F.
Langerhans cell histiocytosis (LCH) is an uncommon clinically heterogeneous disorder characterized by the proliferation and accumulation of Langerhans cells with local infiltration of tissues and organ destruction. LCH takes many clinical forms, affecting different systems and different sites in the same system with variable outcomes. Bone, skin, lymph node, pituitary, liver, lung, bone marrow and spleen involvement can be seen in patients with LCH. Involvement of the perianal site is rare. In this article, a 16-month-old boy with multiple organ involvement including skin, liver, lung, and bone is presented. Aside from these systemic involvements, he also had a simple anal fistula. According to our best knowledge, this case of LCH with anal fistula is only the second to be reported in childhood. We would like to emphasize that LCH may be associated with anal fistula; therefore, we suggest that patients with LCH should be examined for this condition.
A Case of Wilms’ Tumor With Spinal Cord Involvement
(2003) Bay, A.; Akbayram, S.; Öner, A.F.; Çaksen, H.; Köseoğlu, B.; Ünal, Ö.
Wilms’ tumor is the most common renal tumor of childhood. However, spinal cord involvement has rarely been reported in children with Wilms’ tumor. In this article, we report a 5-year-old boy with Wilms’ tumor who had the unusual presentation of spinal cord involvement. Our purpose is to emphasize that spinal cord involvement may be seen in children with Wilms’ tumor. © 2003, IOS Press. All rights reserved.
Ceftriaxone Induced Thrombocytopenia in a Child
(Comenius Univ, 2011) Akbayram, S.; Akgun, C.; Dogan, M.; Caksen, H.; Oner, A. F.
A variety of diseases, hereditary conditions, toxins and drugs may cause thrombocytopenia. Thrombocytopenia induced by ceftriaxone has been rarely reported. In this case, ceftriaxone-induced thrombocytopenia is presented in a 2-year-old girl due to rare presentation (Ref. 10). Full Text in free PDF www.bmj.sk.
Central Nervous System Involvement in a Case of Familial Hemophagocytic Lymphohistiocytosis With Perforin Mutation
(Medecine Et Hygiene, 2011) Akbayram, S.; Akgun, C.; Dogan, M.; Caksen, H.; Okur, H.; Oner, A. -F.
Central nervous system involvement in a case of familial hemophagocytic lymphohistiocytosis with perforin mutation: Familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive lethal condition characterized by fever, cytopenia, hepatosplenomegaly and hemophagocytosis. The presence of central nervous system involvement has a profound impact on the prognosis, treatment, and clinical outcome of the disease. Therefore, the identification of the clinical manifestations of the disease and the characterization of the accompanying neurological symptoms are of prime importance for the rapid diagnosis and subsequent clinical management of the disease. Herein, we report a case of FHL with homozygosity for perforin gene mutation, who presented with central nervous system involvement in the absence of systemic findings.
Chondrodysplasia Punctata Associated With Tetralogy of Fallot in a Newborn Infant
(Medecine Et Hygiene, 2010) Akgun, C.; Akbayram, S.; Tuncer, O.; Taskin, G.; Ceylan, A.
Clinical and Haematological Manifestations of Typhoid Fever in Children in Eastern Turkey
(Univ West indies Faculty Medical Sciences, 2016) Akbayram, S.; Parlak, M.; Dogan, M.; Karasin, G.; Akbayram, H. T.; Karaman, K.
Objective: Typhoid fever can involve various organs, leading to a wide range of presentations: from uncomplicated to complicated typhoid fever. The haematological changes are common in typhoid fever and include anaemia, leucopaenia, thrombocytopaenia and bleeding diathesis. This study was undertaken in order to determine the clinical and haematological presentation of typhoid fever in children. Methods: In this study, records of children and adolescents with typhoid fever aged under or equal to 16 years, admitted to Yuzuncu Yil University Hospital between 2010 and 2014, were analysed retrospectively. Results: The cases (56%) were admitted to our hospital in July and October. Major symptoms of patients were abdominal pain (24%), arthralgia (21%) and fever (11%). In our study, decreased mean platelet volume (31%), eosinopaenia 20%), abnormal platelet count (19%), anaemia (16%), leucocytosis (16%) and eosinophilia (12%) were the most common haematological findings in the children. Conclusions: Typhoid fever is predominant in children at school age with a slight male predominance. Decreased mean platelet volume and abdominal pain might be useful as early diagnostic clues.
Evaluation of Children With Neurobrucellosis
(Comenius Univ, 2012) Akbayram, S.; Dogan, M.; Peker, E.; Bektas, M. S.; Caksen, H.; Karahocagil, M.
Background: Brucellosis is an endemic disease in many areas throughout the world. Central nervous system involvement is a serious complication of brucellosis with a ratio of 4-11% of all patients. Aim: to describe our experience in diagnosis, treatment, and outcome of 25 pediatric patients with neurobrucellosis. Patients and methods: This study included a review of medical records of patients who were diagnosed with neurobrucellosis between March 2001 and March 2009. Patients who had both clinical findings consistent with neurobrucellosis and positive microbiologic/serologic examinations of CSF with abnormal CSF findings were enrolled in the study. Results: The study included 25 patients between 1 and 15 years of age (mean 8.8 years), while 15 were males and 10 were females. Most of the patients (52 %) were in the age group of 5-9 years with male predominance. The distribution of cases showed density in June and February. The most commonly presented complaints were headache, fever and sweating while the most commonly observed findings were fever and meningeal irritation signs. All patients had positive cerebrospinal fluid agglutination test for brucellosis. Four different regimens were used based on ceftriaxone, doxycycline, cotrimoxasole, streptomycin, and rifampicin. One patient died, three patients were discharged with sequel, and the remaining patients (84 %) were discharged with full recovery. Conclusion: Clinicians, especially those providing health services in endemic areas like Turkey, should keep in mind that neurobrucellosis can be involved in patients with unexplained symptoms like memory impairment or in patients diagnosed with meningitis (Tab. 5, Fig, 2, Ref. 39). Full Text in PDF www.elis.sk.
Ewing's Sarcoma Localized in the Mandible: a Case Report
(Univ West indies Faculty Medical Sciences, 2015) Akbayram, S.; Basaranoglu, M.; Kaya, A.; Acikgoz, M.; Ustyol, L.; Taskin, G. A.; Dogan, M.
Ewing's sarcoma is one of the most aggressive primary bone tumours. Ewing's sarcoma arising from the bones of the head and neck region is extremely rare; only 4-9% of all Ewing's sarcoma originate in this region. We report a case of Ewing's sarcoma localized in the mandible because of its unusual presentation.
The Frequency of Consanguineous Marriage in Eastern Turkey
(Medecine Et Hygiene, 2009) Akbayram, S.; Sari, N.; Akgun, C.; Dogan, M.; Tuncer, O.; Caksen, H.; Oner, A. F.
The frequency of consanguineous marriage in Eastern Turkey: Objective: The rate of consanguineous marriage (CM) varies depended on different factors such as race, characteristics of population, and religion and moral features in different countries. Gene frequency and genetic structure are changed by CMs. The aim of the present study is to assess the prevalence of CM and its effects on miscarriage, stillbirth, congenital malformation and ratio of newborn death. Methods: This study was performed in Van region, Eastern Turkey, between September 2005 and April 2006. A total of 650 families from 24 districts chosen in accordance with the number of inhabitants were included in this study. First cousin marriages were accepted as a first degree CMs, sesquialter and second cousin marriages as second degree and marriages between distant relatives were accepted as a third degree CM. Monthly income of the families was classified in accordance with minimum wage determined by government. Results: Of all families, 224 (34.4%) had CM, and 168 (75%) had first-degree consanguinity. A lower CM rate was found in mothers who graduated from secondary school or upgrading (p <0.01). However, no relationship was found between CM and fathers' education level. While a low CM rate was found in families who had two or less children (p <0.01), high rate was observed in families who had five or more children. In addition, a high rate of miscarriage, stillbirth and mental-motor retardation was found in families with CM (p <0.05). The rate of child mortality between the aged 0-2 years was found to be higher in families with CM (p <0.01). The higher CM rate was observed in families who married due to pressure or insistence of their families than married voluntarily (p <0.05). Conclusion: Our study showed that CM rate was very high, 34.4%, in our region Eastern Turkey.
Hematological Findings in 622 of Children With Brucellosis in Eastern Turkey
(Pergamon-elsevier Science Ltd, 2015) Akbayram, S.; Karaman, K.; Bayhan, G.; Akbayram, H.; Dogan, M.; Parlak, M.; Oner, A.
Hyperlipidemia in Infant Case of Acute Monoblastic Leukemia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Ece, İ.; Dogan, M.; Akbayram, S.; Ceylan, N.; Demir, N.; Demirören, K.
Severe hyperlipidemia is a rare presentation usually associated with acute myeloid leukemia. 2-month-old girl complaining of discomfort. Her skin and conjunctivae were pale, abdominal distention and 5 cm hepatosplenomegaly were determined. Blood count revealed anemia (10 g/dL) and thrombocytopenia (41x109/L). Total leukocyte count was 24x109/L, and on blood smear, 58% blast and 42% lymphocytes were seen. Bone marrow aspirate revealed diffuse infiltration with blast cells consistent with acute monoblastic leukemia. Her plasma had a milky appearance. In the laboratory examination, triglyceride level was 1428 mg/dl, cholesterol level was 1291 mg/dl. This case report illustrate that the hematological malignancies may present with severe hypertriglyceridemia. © 2016, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Hypnotic Intervention for Pain Management in a Child With Sickle Cell Anemia
(2001) Aǧargün, M.Y.; Öner, A.F.; Akbayram, S.
Image and Diagnosis
(2004) Akbayram, S.; Çaksen, H.