Browsing by Author "Akbulut, T."

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Containment Measures Established During the Covid-19 Outbreak and Its Impact on Lipid Profile and Neutrophil To Lymphocyte Ratio
(Verduci Editore s.r.l, 2020) Aladağ, N.; Şipal, A.; Atabey, R.D.; Akbulut, T.; Asoğlu, R.; Özdemir, M.
OBJECTIVE: Almost all countries announced social restrictions and distancing measures which could unintentionally lead to a decline in admissions to hospital for acute disorders other than signs of pneumonia. We aimed to evaluate lipid profile, neutrophil to lymphocyte ratio (NLR) and cardiovascular admissions to the coronary care unit (CCU) of a tertiary center in Turkey during the COVID-19 era and to compare these results with admissions in the same time interval of the previous year. MATERIALS AND METHODS: We retrospectively analyzed CCU admissions due to new-onset atrial fibrillation, ST-elevation myocardial infarction, non-ST elevation acute coronary syndrome (NSTEACS) and acute heart failure during the COVID-19 outbreak and the same time interval of the past year. Laboratory measurements including lipid profile and NLR values were retrieved from the institutional digital database. RESULTS: Compared to the same time interval of 2019 (March-April, 2019), the number of patients admitted to the CCU with acute cardiovascular disorders (atrial fibrillation, STEMI, NSTEACS and acute heart failure) were lower in the COVID-19 period. The levels of NLR, total cholesterol, and low-density lipoprotein (LDL) cholesterol were significantly higher and high-density lipoprotein (HDL) cholesterol was significantly lower in subjects admitted to the CCU during March-April 2020 compared to subjects admitted in March-April 2019. CONCLUSIONS: Our findings show that subjects admitted to the CCU in the COVID-19 era have an unfavorable lipid profile and elevated NLR compared to those admitted in 2019. These patients appear to be at high risk for future cardiovascular events. © 2020 Verduci Editore s.r.l. All rights reserved.
Difficulties in Diagnosing Fabry Disease in Patients With Unexplained Left Ventricular Hypertrophy (Lvh): Is the Novel Gla Gene Mutation a Pathogenic Mutation or Polymorphism
(Sciendo, 2023) Aladag, N.; Barman, H. Ali; Sipal, A.; Akbulut, T.; Ozdemir, M.; Ceylaner, S.
Fabry disease (FD) is an X-linked, lysosomal glycosphingolipid storage disorder that occurs very rarely. Cardiac involvement may comprise of left ventricular hypertrophy (LVH), arrhythmias, conduction abnormalities, heart failure and valvular abnormalities. The goal of this study was to conduct gene analysis for FD in patients suffering from unexplained LVH. 120 patients over the age of 30 who were diagnosed by echocardiography with idiopathic LVH were included in the study. Patients with severe hypertension, intermediate valve disease such as moderate aortic stenosis, known FD, and a family history of autosomal dominant hypertrophic cardiomyopathy were excluded from the study. GLA gene mutations were studied by Sanger sequence analysis in all patients. Of the 120 total patients included in this study, 69 were female (58%) and 51 were male (42%). The mean age was 60.3 & PLUSMN; 15.7. GLA gene mutations were detected in three male patients. The detected mutations are as follows: NM_000169.2:IVS6-10G>A (c.1000-10G>A), NM_000169.2:c.937G>T (p.D313Y) (p.Asp313Tyr) and NM_000169.2:c.941A>T (p.K314M) (p.Lys314Met). Early diagnosis is of vital importance in FD, which can be treated with enzyme replacement. Genetic screening in patients diagnosed with idiopathic LVH by echocardiography is important in the early diagnosis and treatment of FD. Patients over 30 years of age with idiopathic LVH should be screened for FD. Various new polymorphisms can be detected in genetic screening. Identifying new polymorphisms is important for knowing the true mutations in FD.
The Effect of Cold Spray Applied Before Local Anesthesia on Anxiety and Pain in Coronary Angiography Procedure: a Randomized Controlled Study
(W.B. Saunders, 2024) Sir, Ö.; Kaplan, E.; Akbulut, T.
Purpose: Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. Clinically, various techniques are used to diagnose coronary artery diseases. Coronary angiography is considered the gold standard for the diagnosis of coronary artery disease. The aim of this study is to determine the effect of cold spray applied before local anesthesia on pain and anxiety during coronary angiography procedures. Design: The study was designed as a randomized controlled trial. Methods: The study was conducted in the angiography unit of a training and research hospital between January and March 2023. Data collection tools included a patient information form, Visual Analog Scale, and State-Trait Anxiety Inventory. Results: When the total mean scores of the Visual Analog Scale of the individuals in the intervention and control groups were examined, a statistically significant difference was found between the mean scores of the patients in the intervention group and the control group (P < .05). A significant difference was found between the individuals in the intervention and control groups in terms of the total scores of the state anxiety scale after cold spray (P < .001), with the mean scores of the control group higher than the intervention group. Conclusions: The application of cold spray before local anesthesia in coronary angiography significantly reduced pain and anxiety levels. © 2024 The American Society of PeriAnesthesia Nurses
Effect of Zinc Supplement and Weight Lifting Exercise on Thyroid Hormone Levels
(Association of Physiologists and Pharmacologists of India, 2017) Cinar, V.; Akbulut, T.; Sarikaya, M.
The aim is to determine the effect of 6-week zinc supplement and weight lifting exercise on the thyroid hormone levels. Study participants were 40 males, age between 18-22 years; 20 sedentaries and 20 individuals who do physical exercises. Subjects were divided equally into 4 groups. Which is: The sedentary group (S) control group,Sedentary group which is supplied withonly zinc (Z+S),Training Group which is supplied with zinc (Z+T) and Athletes Group that train regularly (T). Zinc supplement was given 3mg/kg/day/6 weeks as oral. At the beginning of the study and after 6-week training, the blood samples were drawn from the participants before and after the treatments; and TSH, FT3 and FT4 levels of the participants were determined. It was identified that thyroid values of groups which were supplied with zinc decreased owing to the training and zinc supplement. Consequently, it is thought 6-week zinc supplement and exercise can contribute to the athletes’ performance by changing thyroid values positively. © 2017, Association of Physiologists and Pharmacologists of India. All rights reserved.
The Effects of the Zinc Supplementation and Weight Trainings on the Testosterone Levels
(South Ural State University - Institute of Sport, Tourism and Service, 2017) Çınar, V.; Talaghir, L.G.; Akbulut, T.; Turgut, M.; Sarıkaya, M.
Aim. The purpose of this study, it has been aimed to examine the effects of zinc supplementation applied with weight trainings on the testosterone levels in sedentary individuals and athletes. Materials and Methods. As methods of work it was selected 40 male, 20 sedentary male and 20 male who do physical exercises regularly, participated in the study. The participants are divided equally into 4 groups. The groups are constituted in that way: 1st Group: Control Group (S), 2nd Group: Sedentary Group which is supplied with Zinc (Z), 3rd Group: Training Group which is supplied with Zinc (ZT) and 4th Group: Athletes' Group who performs the weight training (T). The total testosterone and free testosterone values of the participants were measured from the blood samples which were drawn from the participants at the beginning and at the end of the 6-week training period. Results. Like results, has been asserted that the total and free testosterone values of the groups which are supplied with Zinc and perform weight training have increased depending on training and supplementation. Conclusion. In conclusion consequently it has been determined that 6-week zinc supplementation and weight training increase the testosterone levels. Accordingly, it may be said that this implementation contributes to the performance. © 2017 South Ural State University - Institute of Sport, Tourism and Service. All rights reserved.