Browsing by Author "Akdeniz, H"

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Brucellar Oligoarthritis Involving the Left Temporomandibular, Left Sternoclavicular and Left Ankle Joints
(Clinical & Exper Rheumatology, 1997) Adak, B; Tekeoglu, I; Kutluhan, A; Akdeniz, H; Sakarya, ME; Ugras, S
Brucellosis Incidence in Subjects With Headache in Eastern Turkey
(Dr Dietrich Steinkopff verlag, 2004) Anlar, O; Tombul, T; Akdeniz, H; Kisli, M; Kocturk, F; Caksen, H
Central Nervous System Brucellosis
(W B Saunders Co Ltd, 1998) Akdeniz, H; Irmak, H; Anlar, Ö; Demiröz, AP
Although neurological symptoms in brucellosis are frequent,, central nervous system (CNS) involvement is uncommon. Five patients with neurobrucellosis are presented. Three patients presented with meningoencephalitis, one with polyradiculoneuritis and one with myelitis and an eighth nerve palsy. All patients had lymphocytic pleocytosis, low glucose and elevated levels of protein in the cerebrospinal fluid (CSF). Gamma-globulin and IgG values in the CSF were also increased. Results of agglutination tests for Brucella in serum and CSF were positive for all patients, although titres were less in the CSF. Brucella melitensis was cultured from two patients. Treatment included concurrent administration of three of the following drugs: doxycycline, rifampicin, streptomycin, co-trimoxazole, ceftriaxone or ciprofloxacin. The three patients with meningoencephalitis fully recovered; the other two patients were left with minor disability.
Chronic Hepatitis Delta Virus Infection in Eastern Turkey
(Elsevier Science Bv, 2003) Turkdogan, MK; Bozkurt, H; Tuncer, I; Uygan, I; Irmak, H; Buzgan, T; Akdeniz, H
Cutaneous Findings, Encountered in Brucellosis and Review of the Literature
(Wiley, 2001) Metin, A; Akdeniz, H; Buzgan, T; Delice, I
Background Human brucellosis is an infectious disease produced by Brucella species: small, coccoid or rod-like, aerobic, Gram-negative bacteria. The infection is common in developing countries, and can also affect the skin. Its prevalence is high in our region of where stockbreeding is one of the main economic sources, compared with the Turkey, industrially developed areas of Turkey, and dermatologic complaints due to brucellosis, are fairly common. Materials and methods One hundred and three patients with serologically and clinically confirmed brucellosis were studied in order to investigate the prevalence of cutaneous findings and their variability in brucellosis. Fifty-two (50.49%) were males and 51 (49.51%) were females with an age range of 4-70 years (mean, 30.45 +/- 15.08 years). Results Of these patients, 14 (13.59%) had cutaneous findings probably related to brucellosis. These findings were more frequent in females (11 cases) than males, and most of the females (eight cases) were housewives; three were students. Urticaria-like papules, and plaques were the most common findings; they were seen in six (35.3%) patients. One case had livedo reticularis and another palmar erythema, which have not been reported previously. No relationship was observed between the serologic, values and the cutaneous findings. Conclusions Cutaneous findings in our cases were more prevalent than in other reported studies. It is important to emphasize that cutaneous lesions are not specific to brucellosis and may be seen in a variety of other dermatologic diseases caused by many agents; therefore, these agents should be kept in mind in the differential diagnosis.
Cutaneous Manifestations of Anthrax in Eastern Anatolia
(Okayama Univ Med School, 2003) Irmak, H; Buzgan, T; Karahocagil, MK; Sakarya, N; Akdeniz, H; Çaksen, H; Demiröz, P
Anthrax is essentially a disease of grazing herbivorous animals. The most common form of the disease is cutaneous anthrax, which accounts for 95% of all cases. We report here 39 cutaneous anthrax cases in humans that were seen in Eastern Anatolia over a six-year period. The clinical presentation was malignant edema in 16 of the cases (41%) and malignant pustule in 23 (59%). A secondary bacterial infection was present in 13 patients (33.3%) in the vicinity of the lesions. The agent was observed using Gram-stained smears in 25 patients (64%), and Bacillus anthracis was isolated from 15 patients (38.5%). All of the patients were treated with penicillin G or penicillin procaine, except one patient who had a penicillin allergy. One patient with cervical edema (2.5%) died as a result of laryngeal edema and sepsis syndrome. In conclusion, we found that the appearance of the skin lesion of cutaneous anthrax may vary, and this fact, combined with the rarity of this disease, which contributes to a general lack of experience among medical personnel, may make diagnosis difficult in nonagricultural settings.
Determination of the Chemical Composition and Digestible Dry Matter Yields of Some Grain Sorghum Varieties
(Scientific Technical Research Council Turkey, 2003) Akdeniz, H; Karsli, MA; Nursoy, H; Yilmaz, I
The objective of this study was to determine sorghum varieties that are suitable for north Anatolian conditions and possess high nutrient yields. Eight grain sorghum varieties, namely, Ogretmenoglu, Akdari, Aldari, Beydari, Ramada, A-298, DK-64 and KS-397, were utilized as plant material in the experiment. When the grains were mature, they were harvested first, and then residues were harvested by hand. Samples were analyzed for dry matter (DM), organic matter (OM), crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF), and in vitro DM digestibility. Digestible DM yields were also calculated. The DM content of residues ranged from 26.64% to 35.36% (P < 0.05). Concentrations of OM in residues were significantly lower (P < 0.05) in Ramada and Aldari compared with the other varieties. While NDF and ADF concentrations in residues were highest in Beydari, they were lowest in DK-64 (P < 0.05). Residues of DK-64 and Aldari had the highest in vitro digestibilities, DM yields and digestible DM yields (P < 0.05). Ogretmentoglu grain had the highest CP, whereas Beydari had the lowest in vitro digestibility (P < 0.05). Ramada grain had the highest DM and digestible DM yields (P < 0.05). Total (forage + grain) DM yield, digestible DM yield and CP yield were significantly higher in Ramada and A-298 compared with the other varieties (P < 0.05). It can be concluded that, of the sorghum varieties grown, Ramada had the highest yield and adaptation for north Anatoilan conditions, followed by A-298, based on digestible DM and CP yields, respectively.
Effect of Addition of Urea or Urea Plus Molasses To Different Corn Silages Harvested at Dough Stage on Silage Quality and Digestible Dry Matter Yield
(Taylor & Francis Ltd, 2003) Demirel, M; Yilmaz, L; Deniz, S; Kaplan, O; Akdeniz, H
To study the effects of 0.5% urea and 0.5% urea plus 4% molasses addition to different corn silages on its quality, in vitro dry matter digestibility (IVDMD) and digestible dry matter (DDM) yields, four corn cultivars, Arifiye, Frassino, Rx-947 and 3394 harvested at dough stage, were ensiled in cite litre silos for 90 days. Supplement, cultivars interactions were significant for most of the parameters studied, pH of all the silages was within desirable range. Among organic acids, lactic acid was highest in Rx-947, supplementation making no difference. IVDMD was highest in silages Rx-947 and 3394 supplemented either with urea or urea plus molasses. The highest DDM yields were in silages of supplemented or unsupplemented Arifiye and 3394 cultivars followed by Frassino. Thus these three cultivars with or without supplementation are recommended for silage making.
Effect of Estrogen on Fibrinogen Clotting Time in Rabbits
(Scientific Technical Research Council Turkey, 1998) Ercan, M; Yegin, E; Akdeniz, H; Irmak, H; Bayiroglu, F; Tuncer, I
The aim of this study was to examine the effect of estrogen on fibrinogen clotting time in rabbit model experimentally, The study was performed on 14 white New Zealand race female prepubertary rabbits at two months old weighing meanly 1.4+/-0.3 kg. Blood samples was taken from ear veins of the rabbits and first fibrinogen clotting time levels were measured to obtain control values. Next day, female sex hormone preparate estradiol valerinate at a dose of 0.3 mg/kg were injected to the rabbits IM. In their examinations made on 10(th) day of injection, they were evaluated as in oestrus and under the maximal effects of estrogen, acid their blood samples were taken again to measure their fibrinogen clotting time levels. Fibrinogen clotting time levels were determined from blood samples taken before and after female sex hormone administration. Samples taken from ear veins of the rabbits were used for measurement of fibrinogen clotting time. In the study, fibrinogen clotting time values were found meanly 18.13+/-1.00 sec. from blood samples taken before estrogen injection versus 18.87+/-0.61 sec. from blood samples after 10 days of estrogen injection, in statistical assessment performed, there were not statistically significant differences (t=0.94, p>0.05) between fibrinogen clotting time values before and after estrogen administration. Our data revealed that estrogen administration caused a silghtly but insignificantly increase in fibrinogen clotting time values in the rabbits.
The Effect of Levamisole Combined With the Classical Treatment in Chronic Brucellosis
(Tohoku Univ Medical Press, 2003) Irmak, H; Buzgan, T; Karahocagil, MK; Evirgen, Ö; Akdeniz, H; Demiröz, AP
Levamisole is an immunopotenciator drug which is used as an antihelmintic drug as well as very effective remedy on cellular immunity compared with humoral immunity. A total 71 patients (37 men, 34 women) who referred to our department between March 1997 and December 2001, with a history of the disease for about I year, were diagnosed as having chronic brucellosis through those tests brucella serum agglutination test (SAT), SAT with Coombs and SAT with 2-mercaptoethanol. The patients were randomly divided into levamisole group (36 patients) and control group (35 patients). All patients were given rifampicin 600 mg/day + doxycycline 200 mg/day for 6 weeks as a standard classical combined therapy for brucellosis. In the levamisole group, oral levamisole 80 mg every other day for 6 weeks was added to the treatment. There was a statistically significant difference between two groups, in complaints of arthralgia, fatigue and sweats before and 6 months after treatment, as well as in erythrocyte sedimentation rate and C-reactive protein elevations and lymphomonocytosis finding. While it was provided both clinical and serological improvement in all patients in the levamisole group; 11 patients in the control group did not improve both clinically and in view of specific and nonspecific laboratory findings and a recurrence occurred in one case, in this group. In conclusion, levamisole added to classical antibiotic therapy in treatment of chronic brucellosis was found quite efficient in all patients in providing adequate clinical and laboratory response in comparison to classical antibiotic therapy alone. -chronic brucellosis; levamisole; treatment (C) 2003 Tohoku University Medical Press.
The Effects of Maturity on Range Quality and Animal Performance
(Scientific Technical Research Council Turkey, 2003) Karsli, MA; Deniz, S; Nursoy, H; Denek, N; Akdeniz, H
The objective of this study-was to determine the effects of maturity on the range quality and weight gain of male and female lambs, and the time at which supplementation is needed. The experiment was conducted at TIGEM Altindere Agricultural experiment station. At the start of the grazing season, four 4-m(2) areas from 3 different (expected to be heavily grazed) locations of range were excluded from grazing with cages. Dry matter (DM) yield and DM loss due to grazing at different periods of the grazing season were determined from these areas. Forage samples were collected from grazed and ungrazed areas once every two weeks from the 2(nd) week of May to the 2(nd) week of August. Parallel to forage sampling, 20 male and female lambs (a total of 40 lambs) grazing on the pasture were weighed once every two weeks to determine daily weight gains. Dry matter yield, chemical composition (DM, OM, ash, CP, NDF, and ADF) and in vitro DM digestibility of range were determined. Dry matter, NDF and ADF concentrations of forages increased (P < 0.01) and crude protein content decreased (P < 0.01), but organic matter and ash concentrations did not change with increasing maturity. The effect of grazing on the parameters mentioned above was not significant, but increasing maturity significantly affected DM digestibility and DM yields (P < 0.01). At the start of the experiment, DM digestibilities for grazed and ungrazed areas were 69.70 and 69.25%; they declined to 42.45 and 43.45% at the 7(th) sampling, respectively. Dry matter yields for grazed and ungrazed areas were 54.69 and 69.64 for the V sampling, 81.88 and 120.54 for the 2(nd) sampling, 50.55 and 111.74 for the 3(rd) sampling, 59.10 and 97.13 for the 4(th) sampling, 32.82 and 78.81 for the 5(th) sampling, 38.06 and 67.61 for the 6(th) sampling, and 26.96 and 52.65 kg/da for the 7(th) sampling, respectively (P < 0.01). Digestible DM yields for grazed and ungrazed areas were 37.82 and 48.12 for the 1(st) sampling, 51.50 and 78.41 for the 2(nd) sampling, 28.29 and 58.50 for the 3(rd) sampling, 30.15 and 48.18 for the 4(th) sampling, 16.12 and 37.65 for the 5(th) sampling, 17.76 and 31.56 for the 6(th) sampling, and 11.96 and 24.10 kg/da for the 7(th) sampling, respectively (P < 0.01). Both DM and digestible DIM yields were also affected by grazing (P < 0.01). Weight gains, determined parallel to forage sampling, during the 2(nd), 3(rd), and 4(th) periods were high (228, 263, and 182 g/d for male, and 252, 194, and 184 g/d for female lambs, respectively), but were very low after the 4(th) period. It is concluded that the range can meet the nutrient requirements of lambs for optimal weight gain during May and June, but lambs require an extra supplementation for optimal weight gain after June under Northern Anatolian conditions.
The Effects of Sewage Sludge and Nitrogen Applications on Grain Sorghum Grown (Sorghum Vulgare L.) in Van-Turkey
(Hard, 2006) Akdeniz, H; Yilmaz, I; Bozkurt, MA; Keskin, B
The research was conducted in Van, located in the eastern Anatolia region of Turkey. The purpose of this research was to assess environmental hazards to crops and soils from sludge-borne heavy metal; and the potential of using sludge as an alternative to commercial fertilizer, yield, N content and uptake of grain sorghum (Sorghum vulgare L. A-298). Sorghum plants were grown on sandy clay soils under irrigated conditions. Three levels of biosolids were topically applied at rates of 7, 14 and 21 Mg ha(-1); and two level of nitrogen were also applied at rates of 40 and 80 kg ha(-1). The experimental design was a randomized complete block with four replications. Biosolids increased yields of dry matter and grain, plant length, N content of leaves, total N uptake and harvest index (HI). Grain yield was significantly correlated with plant length, N content of leaf and whole-plant, and total nitrogen uptake. Nitrogen harvest index (NHI) did not show significant correlation with any considered parameter other than harvest index. In contrast, nitrogen use efficiency (NUE) had a negative relationship with dry matter (DM) yield, N content of whole-plant, N content of grain and total N uptake. Diethylenetriamine pentaacetic acid (DTPA) extractable Cd, Pb and especially soil Zn concentrations increased with sewage sludge rates. In general, none of the heavy metals studied in both leaves and seed of crop reached either phytotoxic or toxic levels for humans or livestock [1]. The results showed that sewage sludge could be used as N fertilizer in grain sorghum production.
Epileptic Seizures in Neurobrucellosis
(Elsevier, 2005) Tornbul, T; Anlar, O; Caksen, H; Akdeniz, H
Evaluation of the Nutrient Content and Protein Fractions of Four Different Common Vetch Varieties
(Tubitak Scientific & Technological Research Council Turkey, 2005) Karsli, MA; Akdeniz, H; Levendoglu, T; Terzioglu, Ö
The objectives of this study were to determine the chemical composition, digestibility, in situ N kinetics, and by-pass protein contents of 4 different common vetch varieties grown under irrigation. Four different common vetch varieties (Emir 20/1, Nilufer 17/1, 28/1. and Uludag 31/4) with different characteristics were selected. The vetch plots were planted on June 15 2002 and each variety was randomly assigned to 3 replications. The vetches were harvested by hand using a clipper on September 1. All samples were analyzed for dry matter (DM), ash, crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF) and acid detergent insoluble nitrogen (ADIN) concentrations. In vitro dry matter digestibility, and in situ degradability of samples at given times were also determined. While the concentrations of DM and ADIN-N did not differ, concentrations of organic matter (OM), CP' NDF, and ADF varied significantly among different vetch varieties (P < 0.05). The water soluble DM content of Nilufer 17/1 was significantly greater then that of 28/1 (P < 0.05), but in situ DM degradabilities after 48-h incubation, in vitro dry matter digestibilities, and metabolizable energy (ME) and net energy for lactation (NEL) values were statistically similar among the vetch varieties (P > 0.05). While the water soluble protein (WSP) concentration was lower, concentrations of potentially degradable protein (PDP), and by-pass CID as a percentage of total digestible CP or DM were significantly greater in 28/1 than in Nilufer 17/1 and Uludag 31/4 (P < 0.05). However, concentrations of non-degradable protein (NDP) and in situ CP degradabilities after 48-h incubation did not differ among the vetch varieties (P > 0.05). It can be concluded that if high by-pass protein content is desired, 28/1 and Emir 20/1 should be preferred over the other varieties. Otherwise, Nilufer 17/1 and Uludag 31/4 should be first choice, based on DM digestibility and CP contents, because the energy contents and percentage of non-digestible CP did not differ among the vetches.
Hematological Manifestations in Brucellosis Cases in Turkey
(Okayama Univ Med School, 1998) Akdeniz, H; Irmak, H; Seckinli, T; Buzgan, T; Demiroz, AP
The hematological findings of 233 patients with brucellosis are presented and the possible pathologies discussed. Anemia was present in 128 patients (55%), leukopenia in 49 (21%) and thrombocytopenia in 59 (26%). Bone marrow aspirates of 18 patients (8%) with pancytopenia were examined. The bone marrow was hypercellular in 15 and normocellular in 3 patients. Granulomatous lesions were detected in 12 cases (67%), and slight to moderate cytophagocytosis of erythrocytes, granulocytes and platelets existed in all patients. Blood cell counts reverted to normal within 2-3 weeks of initiating chemotherapy with recovery from the disease.
Hydatid Disease in a Thyroglossal Cyst
(Assoc Soc Scientifique Med Belges, 1997) Ugras, S; Demirtas, I; Akdeniz, H; Kutluhan, A; Akpolat, N; Karakok, M
The location of hydatid disease in organs other than the liver and lung is unusual and occasionally producing difficulties in diagnosis. Thyroglossal cyst itself is not so common, so that more careful search of thyroglossal cyst for the presence of scolex and/or laminated membrane may result in increase in frequency of such a condition in the area where hydatid disease is prevailed. Since we were unable to find a case of hydatid disease involving thyroglossal cyst, as in our present case, we feel justified in reporting this case, considering it would be the first publication in world literature.
Report of Five Children With Guillain-Barre Syndrome Following a Nationwide Oral Polio Vaccine Campaign in Turkey
(Neurol Soc india, 2003) Anlar, O; Tombul, T; Arslan, S; Akdeniz, H; Caksen, H; Gundem, A; Akbayram, S
Five children with Guillain-Barre syndrome (GBS), following a national oral polio vaccination campaign to eradicate disease, are reported. Clinical examination, cerebrospinal fluid and electromyographic findings conformed to the classical description of GBS. Four of them received therapeutic dose of intravenous immunoglobulin G. Two children succumbed to the disease. It was observed that the number of cases of,GBS in children increased during the period of the oral polio vaccination campaign in Turkey, suggesting a causal relationship.
Salmonella Myocarditis in a Patient With Wolf-Parkinson Syndrome That Was Confused With an Inferior Myocardial Infarction
(Univ Chicago Press, 1997) Akdeniz, H; Tuncer, I; Irmak, H; Demiroz, AP
The Treatment Duration of Acute Maxillary Sinusitis: How Long Should It Be? a Nasal Smear Controlled Study
(int Rhinologic Soc, 2002) Kutluhan, A; Akdeniz, H; Kaya, Z; Kiroglu, F; Kiris, M; Ugras, S
The aim of this study was to determine the most appropriate duration of treatment in acute maxillary sinusitis. The study was performed prospectively on 40 adult patients with acute maxillary sinusitis diagnosed by sinus puncture. Patients were randomized as to several treatment periods and treated by various antibiotics according to culture-sensitivity results. Patients in group I received treatment for 7 days; groups 2, 3, and 4 received 14, 21, and 28 days, respectively. The patients were followed up with nasal smear findings on certain intervals during the 56-day follow-up period. Statistically significant differences were found beginning from the 21st day between group 1 and the other groups. However, there were no statistical differences among groups 2, 3 and 4. These findings show that the most appropriate duration of treatment in acute maxillary sinusitis should be at least 14 days according to nasal smear results.
Use of the Brucella Igm and Igg Flow Assays in the Serodiagnosis of Human Brucellosis in an Area Endemic for Brucellosis
(Amer Soc Trop Med & Hygiene, 2004) Irmak, H; Buzgan, T; Evirgen, Ö; Akdeniz, H; Demiroz, AP; Abdoel, TH; Smits, HL
The clinical utility of two complementary tests for brucellosis, the Brucella IgM and IgG flow assays, was evaluated in a hospital in eastern Turkey. The results show that the flow assays are convenient diagnostic tests for use in endemic areas. A positive result in the flow assays was obtained in 91% and 97% of the admission sera from adult and pediatric patients with brucellosis, respectively, and the sensitivity at admission was 100% for culture-confirmed brucellosis. The assay system performed equally well in diagnosing patients at different stages of illness including patients with acute, subacute, or chronic disease and with relapse. The results of the flow assays correlated well with those of a serum agglutination test at a cut-off greater than or equal to1:160. The agreement was 92%. Application of the flow assays on serum samples collected during a village survey for brucellosis after an outbreak demonstrated their diagnostic potential as field tests.