Browsing by Author "Akdeniz, N."

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Alstrom Syndrome With Acanthosis Nigricans: a Case Report and Literature Review
(Medecine Et Hygiene, 2011) Akdeniz, N.; Bilgili, S. Gunes; Aktar, S.; Yuca, S.; Calka, O.; Kilic, A.; Kosem, M.
Alstrom syndrome with acanthosis nigricans: a case report and literature review: Alstrom syndrome (AS) is a very rare autosomal recessively inherited disorder that can lead to infantile-onset dilated cardiomyopathy, blindness, hearing impairment, obesity, diabetes, hepatic and renal dysfunction. AS is caused by mutations in the ALMS I gene, which is located at chromosome 2p13. The life span of patients with AS rarely goes beyond an age of 40 years. There is no specific therapy for AS, but early diagnosis and intervention may moderate the progression of the disease and may improve the length and quality of the patient's life. We report a 10 year-old boy presenting with Alstrom Syndrome and acanthosis nigricans.
Alström Syndrome With Acanthosis Nigricans: a Case Report and Literature Review
(2011) Akdeniz, N.; Gunes Bilgili, S.; Aktar, S.; Yuca, S.; Calka, O.; Kilic, A.; Kosem, M.
Alström syndrome (AS) is a very rare autosomal recessively inherited disorder that can lead to infantile-onset dilated cardiomyopathy, blindness, hearing impairment, obesity, diabetes, hepatic and renal dysfunction. AS is caused by mutations in the ALMS1 gene, which is located at chromosome 2p13. The life span of patients with AS rarely goes beyond an age of 40 years. There is no specific therapy for AS, but early diagnosis and intervention may moderate the progression of the disease and may improve the length and quality of the patient's life. We report a 10 year-old boy presenting with Alström Syndrome and acanthosis nigricans.
Assessment of Melanoma Risk in Acquired Melanocytic Nevi Using Digital Dermoscopic and 3-Point Checklist Score
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Yavuz, G.Ö.; Akdeniz, N.; Yavuz, İ.H.; Çalka, Ö.; Bilgili, S.G.
Among skin cancers if not diagnosed early the highest death rate is for malign melanoma. Many studies has showed that multipl nevi lead to an increased risk of melanoma. It is a good option to take photos of patients in periodic intervals. In our study, we calculated the risk of melanoma in patients with acquired melanocytic nevi with 3-point checklist and digital dermoscopy and we aimed to compare the results and their advantages to each other. We enrolled 300 patients with acquired melanocytic nevi in our study. Cases we enrolled in our study were recorded in the pre-prepared patient follow-up form. In this study Fotofinder HD (Germany) digital dermoscopy instruments were used. Lesions that were regarded as malign by 3-point scoring method were excised and histopathologically evaluated. In statistical calculations significance level of 5% was used and calculations were made with SPSS (ver: 13) statistical package program. 157 of our patients were male (52.3%) and 143 (47.7%) were female. Sensitivity of digital dermoscopy was determined as 86% according to the 3-point checklist. 6 Of the 300 patients were diagnosed as malign melanoma. Sensitivity of the 3-point checklist was determined as 97%. In our study, the results of 3-point checklist were detected higher than previous studies. Since digital dermoscopy is easy to use, this method is convenient especially for inexperienced physicians in the diagnosis of malignancy. But dermoscopic algorithms remain as the first choice for specialist physicians. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Brainstem Auditory-Evoked Potentials in Behcet's Disease and Neuro-Behcet Syndrome
(Springer Heidelberg, 2012) Tombul, T.; Gulec, T.; Akdeniz, N.
A Brother and Sister With Werner's Syndrome Demonstrating Extensive Tendon Calcification and Sacroiliitis
(Wiley, 2006) Ozturk, M.; Akdeniz, N.; Ayakta, H.; Kosem, M.
Cutaneous Anthrax in Eastern Turkey
(Wiley, 2008) Karahocagil, M. K.; Akdeniz, N.; Akdeniz, H.; Calka, Oe.; Karsen, H.; Bilici, A.; Evirgen, Oe.
Background. Anthrax is a zoonotic disease diminishing worldwide. Although a very rare disease in developed countries, anthrax is still endemic in developing countries. Aim. To evaluate the clinical history and features, treatment and outcome of our patients with anthrax and emphasize the importance of the disease in our region. Method. In this study, the records of all patients diagnosed with cutaneous anthrax admitted to Yuzuncu Yil University Medical Faculty between March 2002 and March 2007, were reviewed, and data on age, gender, occupation, clinical symptoms and findings, location and type of lesions, clinical history, laboratory findings, treatment and outcome were recorded. Results. There were 85 patients [46 (54.1%) male, 39 (45.9%) female; mean age 30.6 years, range 6-72]. All the patients had a history of contact with infected animals or animal products. The infectious agent was found using direct examination of Gram-stained smears from 17 patients (20%), and Bacillus anthracis was isolated from vesicle fluid cultures from 11 patients (12.9%). Diagnosis was based on clinical findings in the remaining 57 patients (67.1%). All patients, except for two with respiratory tract obstruction, made a full recovery. Conclusion. Anthrax continues to be an endemic disease in Turkey, and should be considered in patients with a relevant contact history having a painless ulcer and vesicular skin lesions surrounded by a zone of oedema. Gram staining and simple culture methods are useful aids to diagnosis, but diagnosis may have to be based on clinical grounds in the majority of patients.
Evaluation of Related With Age of Ifn-Gamma Levels of Treated Leprosy Patients and Their Healthy Relatives Compared With a Control Group
(2006) Güdücüoglu, H.; Berktaş, M.; Bozkurt, H.; Akdeniz, N.; Kutluay, N.; Yaman, G.; Andiç, S.
OBJECTIVE: This study was to search how change with age of IFN-gamma (IFN-gamma) levels of leprosy patients who had received or still undergoing treatment, their healthy close relatives and healthy people. METHOD: From a total of 39 patients, 28 had received leprosy treatment and recovered with some defects [17 Lepromatous Leprosy(LL), 7 Borderline Lepromatous (BL), 3 Borderlien Tuberculoid (BT), 1 Tuberculoid form (TT)] and 11 (9 LL, 2 BL) were undergoing therapy in a hospital at that moment. Close relatives of the patients included 39 people living with treated patients in the same house and the control group consisted of 39 healthy people. Human IFN-gamma kits were used as a solid phase sandwich ELISA method. RESULTS: The IFN-gamma values of treated leprosy patients, therapy receiving patients, relatives group's and control group's were detected as 11-20 pg/mL, 11-18 pg/mL, 12-145 pg/mL and 12-65 pg/mL respectively. CONCLUSION: According to the statistical evaluation of these three groups, IFN-gamma levels of patients were detected lower than other two groups. According to the age, if IFN-gamma levels were compared, it was detected that significant relationship between relatives groups and interferon gamma levels.
Genital Molluscum Contagiosum in an Infant
(2012) Serap Karadaǧ, A.; Akdeniz, N.; Çalka, Ö.; Güneş Bilgili, S.; Tas Demircan, Y.
Molluscum contagiosum (MC) is a viral disorder of the skin and mucous membranes, is characterized by domeshaped umbilicated, flesh-colored papules. In pediatric patients, the lesions are mostly seen on face, trunk and extremities. Genital MCV infection is often transmitted sexually and associated with concurrent sexually transmitted diseases. The presence of genital MC may be a sign of a child abuse. Two year- old female referred to our clinic with the lesion characterizing by dome-shaped, umblicated and flesh-colored papules in the anogenital area. Her family was queried for child abuse and there was no evidence of child abuse. We report this MC lesion because of its rare location.
Hairy Tongue: a Case Report
(2004) Yuca, K.; Calka, O.; Kiroglu, A.F.; Akdeniz, N.; Cankaya, H.
Hairy tongue or black hairy tongue is a benign condition characterized by hypertrophy of the filiform papillae that give the dorsum of the tongue a furry appearance. The color of the elongated papillae varies from yellowish white to brown or black. The etiology is unclear, but the disorder has been associated with numerous predisposing conditions such as heavy smoking, poor oral hygiene, use of topical or systemic antibiotics, systemic corticosteroid therapy, yeast infections, and radiotherapy for head and neck malignancies. A case is presented in which a hairy tongue appeared in a 67-year-old man.
Incontinentia Pigmenti With Ocular Involvement: Two Cases
(Medecine Et Hygiene, 2012) Bilgili, S. G.; Karadag, A. S.; Karadag, R.; Akdeniz, N.; Bulut, G.; Calka, O.
Incontinentia pigmenti with ocular involvement: two cases: Incontinentia pigmenti (IP) is a rare, X-linked dominant disorder that presents at or soon after birth and presents with cutaneous signs and symptoms. Besides its typical skin signs presenting in all patients, central nervous system (CNS), ophthalmologic and dental involvement are encountered as well. In this report, we present two patients at the verrucous stage of IP and review the literature concerning the diagnosis and course of IP.
Mucocutaneous Disorders in Children With Down Syndrome: Case-Controlled Study
(Medecine Et Hygiene, 2011) Bilgili, S. Gunes; Akdeniz, N.; Karadag, A. S.; Akbayram, S.; Calka, O.; Ozkol, H. Uce
Mucocutaneous disorders in children with Down syndrome: case controlled study: Objective: Down's syndrome is the most frequent chromosomal anomaly that can affect a multiple organ systems, including skin. In this study, we compared the frequency of mucocutaneous disorders in children with Down's syndrome with normal children. Methods: We recruited fifty children with Down's syndrome and 50 healthy children as a control in our study. Mucocutaneous abnormalities were examined in both groups. Findings: Of 50 patients, 22 were girls and 28 were boys. The skin findings such as xerosis and Mongolian spots were the most frequently seen in the patients with Down's syndrome. Seborrheic dermatitis, cheilitis and fissured tongue were seen frequently, as well. The rare findings were plantar hyperkeratosis, alopecia areata, geographic tongue, cafe-au-lait macula, livedo reticularis, cutaneous infections, pityriasis capitis simplex, cutis marmorata, neurotic excoriation, trichotillomania, keratosis pilaris and diaper dermatitis. No mucocutaneous finding was seen in 16 patients. The prevalence of the skin disorders including Mongolian spot, seborrheic dermatitis, cheilitis, fissured tongue was significantly higher in patients with Down syndrome than normal individuals (p<0.05). Conclusion: Therefore, large-scaled epidemiological studies covering the entire population are needed. We believe that these studies could provide better understanding the dermatological diseases in children with Down's syndrome that would help to practitioners to treat these problems.
Nine Case Series With Phototoxic Dermatitis Related To Chenopodium Album
(Sage Publications Ltd, 2012) Ozkol, H. U.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Bilgili, S. G.; Behcet, L.
Chenopodium album L. ssp. album is a common plant species worldwide, especially in humid areas. Sun exposure after oral intake of the plant can lead to sunburn-like rashes owing to its furocoumarin content. In this article, we reported nine patients who developed dermatitis with edema, erythema and necrosis on the face and dorsum of the hands. Each was exposed to sunlight after eating selemez (the vernacular name of C. album L. ssp. album). The plant samples analyzed by an expert botanist were described as C. album L. ssp. album belonging to Chenopodiacea family.
Nitric Oxide Levels in Atopic Dermatitis
(2004) Akdeniz, N.; Aktaş, A.; Erdem, T.; Akyüz, M.; Özdemir, Ş.
Atopic dermatitis (AD) is a chronic or chronically relapsing inflammatory skin disease characterized by typically distributed eczematous skin lesions with lichenification, pruritic excoriations, dry skin and a susceptibility to skin infections. Nitric oxide is a molecule which is produced in endothelial cells, neuronal cells, fibroblasts, platelets, macrophages and neutrophils by nitric oxide synthetase, which plays a role in important biological and pathological processes. Nitric oxide, whose release is induced by cytokines and endotoxins, is produced in excessive amounts in acute, chronic inflammatory as well as infectious conditions. The purpose of our research was to determine nitric oxide (NO.) values in patients with atopic dermatitis through spectrophotometric analysis. Data obtained from 22 atopic dermatitis patients and from 16 healthy controls were compared. The disease was mild (mild group), moderate (moderate group) and severe (severe group). Mean serum NO. levels were significantly higher in patients than in controls. Among patient groups, while there was no significant difference between mild and moderate groups, a significant difference was found between mild and severe groups, and between moderate and severe groups.
Nonsteroidal Anti-Inflammatory Drugs-Induced Generalized Fixed Drug Eruption: Two Cases
(Sage Publications Ltd, 2012) Bilgili, S. G.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Kosem, M.
Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.
Oesophageal Involvement During Attacks in Pemphigus Vulgaris Patients
(Wiley, 2006) Calka, O.; Akdeniz, N.; Tuncer, I.; Metin, A.; Cesur, R. S.
Pemphigus vulgaris (PV) is a rare autoimmune bullous skin disorder characterized by frequent involvement of the mucous membranes, usually beginning at the mouth. To investigate the oesophageal involvement in patients with PV and to explore the primary relationship of the disease with symptoms such as dysphagia, odynophagia and retrosternal burning. Oesophageal involvement was investigated by upper gastrointestinal endoscopy and biopsy during the early phase of the attacks in 26 patients with PV (12 men, 14 women, age range 24-63 years). Histopathological examination and direct immunofluorescence of the oesophageal biopsy specimens revealed pemphigus involvement in 12 of 26 patients (46.15%). The oesophagus is an important predilection zone for PV, thus care must be taken to detect these lesions at an early stage.
Thyroid Autoimmunity Associated With Recurrent Aphthous Stomatitis
(Wiley, 2012) Ozdemir, I. Y.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Ozturk, M.
Background Recurrent aphthous stomatitis (RAS) is an autoimmune disorder characterized by the periodic appearance of aphthous lesions on the oral mucosa. TH1 cytokines plays a key role in the aetiopathogenesis. Autoimmune thyroid disease (ATD) is the most common autoimmune disease and is frequently accompanied by various other autoimmune diseases. Objective To investigate the frequency of ATD which has not been studied in the patients with RAS. Methods Ninety patients and 30 healthy volunteers were included into the study. The serum samples were assayed for thyroid stimulant hormone (TSH), free and total triiodothyronine (fT3, TT3), free and total thyroxine (fT4, TT4), thyroglobuline, anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobuline antibody (anti-TG) levels. Thyroid ultrasonography was performed as well. Results In RAS patients, the fT3, TT3 levels were higher; whereas the fT4 levels were lower that the control group (P < 0.05). The anti-thyroid antibody was positive in 31.11% of the patients with RAS, and in only 10% of the individuals in the control group (P < 0.05). The mean anti-TG level was also higher in the RAS group. Ultrasonography revealed nodules in 28.8% of the patients with RAS and in 16.7% of the individuals in the control group (P < 0.05). The sT4 levels were lower and the TSH, anti-TPO and anti-TG levels were significantly higher in the RAS patients with thyroid nodules than the RAS patients without nodules (P < 0.05). Discussion These results may be related to either the advance age of the patients or the increased duration of the autoimmune activation which may affect the thyroid. Conclusions The frequency of thyroid autoimmune-related problems was higher in patients with RAS. It would be worthy of searching autoimmune thyroid disorders in patients with RAS.
Two Cases With Benign Cephalic Histiocytosis
(2012) Güneş Bilgili, S.; Karadaǧ, A.S.; Akdeniz, N.; Çalka, Ö.; Özaydin Yavuz, G.; Kösem, M.
Benign cephalic histiocytosis is a rare form of non-Langerhans cell histiocytosis in infants and children characterized by a self-healing eruption of papules and macules on the head and neck. Its etiology is unknown. Due to its rarity we report these two cases of benign cephalic histiocytosis. The first case was a 1.5 year-old boy with small, asymptomatic, yellow-brown papules distributed over his trunk and upper extremities and yellow-brown plaques localised bilaterally to his cheeks. The second case was a 16 months old boy with purple-erythematous papules and nodules on his left cheek, left earlobe and right preauricular region ranging from 2 mm to 5 mm in diameter. There were no symptoms or signs of systemic involvement in both of the cases. It is uncommon and can therefore be easily mistaken for other more common skin diseases seen in children. Copyright © 2012 by Türkiye Klinikleri.
Two Novel Mutations in the Men1 Gene in Subjects With Multiple Endocrine Neoplasia-1
(Springer, 2006) Ozturk, M.; Chiu, C. Y.; Akdeniz, N.; Jenq, S. F.; Chang, S. C.; Hsa, C. Y.; Jap, T. S.
Multiple endocrine neoplasia type 1 (MEN1) is characterized by parathyroid, enteropancreatic endocrine and pituitary adenomas as well as germline mutation of the MEN1 gene. We describe 2 families with MEN1 with novel mutations in the MEN1 gene. One family was of Turkish origin, and the index patient had primary hyperparathyroidism (PHPT) plus a prolactinoma; three relatives had PHPT only. The index patient in the second family was a 46-yr-old woman of Chinese origin living in Taiwan. This patient presented with a complaint of epigastric pain and watery diarrhea over the past 3 months, and had undergone subtotal parathyroidectomy and enucleation of pancreatic islet cell tumor about 10 yr before. There was also a prolactinoma. Sequence analysis of the MEN1 gene from leukocyte genomic DNA revealed heterozygous mutations in both probands. The Turkish patient and her affected relatives all had a heterozygous A to G transition at codon 557 (AAG -> GAG) of exon 10 of MEN1 that results in a replacement of lysine by glutamic acid. The Chinese index patient and one of her siblings had a heterozygous mutation at codon 418 of exon 9 (GAC -> TAT) that results in a substitution of aspartic acid by tyrosine. In conclusion, we have identified 2 novel missense mutations in the MEN1 gene.