Browsing by Author "Akdeniz, Necmettin"

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Association of Demodicosis With Acne Rosacea
(Professional Medical Publications, 2010) Cengiz, Tas Z.; Yilmaz, Hasan; Akdeniz, Necmettin; Cicek, Mutalip; Ozkol, Halil; Calka, Oemer
Objectives: Demodex spp of humans are encountered frequently all over the world. The role of these parasites is controversial in the causation of skin diseases. This study was carried out to determine the prevalence and the association of Demodex spp with acne rosacea. Methodology: The study was conducted between the years of 2005-2008 in the output clinic of Dermatology and Parasitology Laboratory of Health Research and Training Hospital of Yuzuncu Yil University. One hundred two patients (patient group) composing of 59 females and 43 males with acne rosacea and randomly selected 50 healthy subjects (control group) were examined for Demodex spp. Twenty seven patients were under the age of 35, and 75 patients were aging 35 years old and over. Samples were plucked out from surface of nose and forehead of patients with acne rosacea and healthy subjects by standardized surface skin biopsy (SSSB) method in the Laboratory. The preparations prepared in Hoyer solution were examined under 4X and 10X objectives of light microscope. Results: The detected parasites were higher in the patient group with acne rosacea (67.65%) than the control group (6%), in females (76.27%) than males (55.81%) and in patients aging 35 years old and over (74.67%) than the patients under 35 years of age (48.15%). Significant relationships were detected between acne rosacea and demodicosis, sex and demodicosis, and age and demodicosis (p<0.001, p<0.05 and p<0.05, respectively). Conclusion: It was concluded that there is a relationship between the demodicosis and acne rosacea, and dermatologists should take into consideration the Demodex spp. in the etiology of acne rosacea.
Atypical Presentation of Herpes Zoster in a Case With Acute Myeloblastic Leukemia
(Elsevier Science Bv, 2013) Aktar, Fesih; Akbayram, Sinan; Akdeniz, Necmettin; Aktar, Sirac; Akgun, Cihangir; Dogan, Murat; Oner, Ahmet Faik
Herpes zoster (HZ) is often associated with painful erythematous vesicular eruptions of the skin or mucous membranes. Approximately 10% to 30% of the population will suffer from HZ during their lifetime. HZ is infrequent in healthy children. However, diminished cellular immunity seems to increase risk of reactivation because incidence increases with age and in immunocompromised states. We report a 7 year old girl with acute myeloblastic leukemia HZ infection on the right palmar, elbow and forearm region (C7, C8 and T1 dermatomes). We want to indicate unusual localization of HZ on the acute myeloblastic leukemia child patient.
Beden Eğitimi Bölümü Öğrencilerinin Yüzeyel Mantar Hastalıkları Açısından Değerlendirilmesi
(2006) Akdeniz, Necmettin; Guducuoglu, Huseyin; Hamza, Bozkurt; Aygül, Kumru; Berktaş, Mustafa; İzci, Hicran
Dermatofitler canlılarda keratinize dokuya saldıran, deri, saç ve tırnakta enfeksiyon yapan keratinofilik mantarlardan olup Epidermophyton, Microsporum ve Trichophyton olmak üzere 3 cinse ayrılmaktadır. Bu çalışmada üniversitemizin beden eğitimi bölümünde okuyan öğrencilerin dermatofit açısından tüm vücut bölgelerinin (cilt, tırnak ve saç) değerlendirilmesi amaçlanmıştır. Olguların değerlendirilmesinde; direkt bakı (%15' lik KOH kullanılarak lam-lamel arası preparatlar) ve kültür [Sabouraud Dekstroz Agar (SDA) besiyeri, Patates-Dekstroz Agar (PDA) ve Mycobiotic agar besiyerleri] yapılmıştır. Toplam 40 öğrencinin yapılan genel cilt, tırnak ve saçlı deri muayenesi sonucunda yüzeyel mantar enfeksiyonları açısından şüpheli 27'sinden yapılan incelemeye göre direkt bakıda 17 örnekte mantar elemanlarına rastlanmış olmasına rağmen, toplam 4'ünde (%10) mikroskobik olarak Malessezia furfur, kültür sonucuna göre ise 3'ünde (%7.5) Trichophyton rubrum tespit edilmiştir. Hedef kitlelerden biri olan sporcuların taranması ile onlarda olabilecek mantar enfeksiyonlarına karşı nasıl korunabileceklerinin anlatılmasının mantar infeksiyonlarından korunmada ve erken tanıda önemli olduğunu düşünmekteyiz.
Bir Folikülitis Dekalvans Olgusu
(2007) Akdeniz, Necmettin; Çalka, Ömer; Özen, Süleyman; Bilgili, Serap Güneş
Folikülitis dekalvans, nadir görülen, saçlı deride skatrisyel alopesiye yol açan, kıl folikülünün inflamatuar bir reaksiyonudur. Çok nadir görülen bir hastalık olduğundan folikülitis dekalvans tanısı koyduğumuz 18 yaşındaki bayan bir hastayı sunmayı uygun gördük.
Bir Olgu Nedeniyle Favre-racouchot Hastalığı
(2003) Akdeniz, Necmettin; Çalka, Ömer; Metin, Ahmet
Favre-Racouchot hastalığı, daha çok ileri yaşlarda ortaya çıkan solar elestozla birlikte özellikle malar bölgelerde komedon gelişimiyle karakterize bir tablodur. Yüzünde solar elastoz zemininde çok sayıda açık ve kapalı komedonlan olan 67 yaşındaki erkek olgu nadir rastlanması nedeniyle sunulmuştur.
A Case of Irritant Contact Dermatitis With Leech
(informa Healthcare, 2011) Karadag, Ayse Serap; Calka, Omer; Akdeniz, Necmettin; Cecen, Ilhan
Medicinal leeches are invertebrated parasites that have been used for medical purposes for centuries as one of the traditional treatment methods. Medicinal leeches are used for wound and flap healing in the plastic and reconstructive surgery, in the treatment of venous insufficiency, varicosities, hemorrhoids, and in many other diseases. However, due to medicinal leech therapy (hirudotherapy) complications such as anaphylaxis, local allergic reactions, anemia, and mucosal synechiae can occur. In this article, we report a case of an irritant contact dermatitis in a patient who experienced severe redness and itching after applying leeches for the relief of head and neck pain. Leeches are being used widely in some regions in the world and if people are informed about the leeches, it may be helpful in preventing complications that may occur.
A Case of Tinea Capitis Favosa Which Persists Up To Adulthood
(Galenos Yayincilik, 2012) Bilgili, Serap Gunes; Calka, Omer; Karadag, Ayse Serap; Akdeniz, Necmettin
Tinea capitis favosa is a dermatophyte infection characterized by scutulum formation, and the causative agent is usually Trichophyton schoenleinii. It is seen most commonly in children, but may follow a lifelong course if remain untreated. The incidence has decreased considerably in recent years in Turkey. We report an 18-year-old female patient diagnosed with tinea capitis favosa. The disease had been present for 10 years owing to misdiagnosis and unsuccessful treatments. She was successfully treated with terbinafine. Since it is a rare condition we present this case.
Childhood Traumatic Experiences, Dissociation and Thought Suppression in Patients With 'psychosomatic Skin Diseases
(Wiley, 2009) Besiroglu, Lutfullah; Akdeniz, Necmettin; Agargun, Mehmet Yucel; Calka, Omer; Ozdemir, Osman; Bilgili, Serap Genes
In this study, patients with what were considered 'psychosomatic' skin diseases were compared with patients with skin conditions that are thought to be 'non-psychosomatic' diseases in terms of their reported history of childhood traumatic experiences, dissociative experiences and thought suppression. Ninety-six patients with 'psychosomatic' skin disease were included in the study. The comparison subjects (n = 54) were patients with skin conditions believed to have a negligible psychosomatic component and the subjects without skin disease (n = 77). Subjects were administered with the Childhood Trauma Questionnaire (CTQ), the Dissociative Experiences Scale (DES) and the White Bear Suppression Inventory (WBSI). While the 'emotional neglect' scores of the psychosomatic' group were significantly higher than that of both 'non-psychosomatic' and healthy subjects, there were no significant differences for the other subscales of the CTQ. The 'psychosomatic' group scored significantly higher on the DES absorption scale, DES total and WBSI scores than the other groups. Significantly more patients in the 'psychosomatic' group reported a stressful life event as related to the onset of skin complaints compared with the 'non-psychosomatic' group. Our results suggest that the effect of subjective perception of emotional neglect, mediated by stressful life events, increases the vulnerability to psychosomatic disease. Copyright (C) 2008 John Wiley & Sons, Ltd.
Clinical Evaluation of Inpatients With Acute Urticaria
(deri Zuhrevi Hastaliklar dernegi, 2011) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer; Akdeniz, Necmettin; Ozkol, Hatice Uce; Aktar, Sirac
Background and Design: To determine the clinical and etiological features of inpatients with acute urticaria and angioedema and to assess the need for laboratory tests. Material and Methods: We recruited 105 patients with acute urticaria and angioedema who were admitted to our inpatient unit. The lesions and the characteristics of the patients were analyzed. Routine diagnostic tests including complete blood count, thyroid function tests, hepatitis panel, stool parasite, total IgE levels, cultures, erythrocyte sedimentation rate, C-reactive protein, anti-nuclear antibody, and posterior anterior lung X-ray were ordered. A psychiatric consultation was obtained, when needed. The results were analyzed with SPSS 15.0 statistical software. Results: Among 105 patients, 28 (26.7%) had urticaria, 7 (6.7%) had angioedema, and 70 (66.70/0) suffered from both urticaria and angioedema. The most common accompanying symptoms were itching (91.40%) and burning (34.3%). The most common systemic symptoms were fatigue (15.2%) and headache (12.4%). The lesions usually appeared in the evening hours (24.8%). Twenty-five patients were waking up due to itching during the night. Some lesions were associated with physical activities. Systemic diseases accompanied the lesions in 12 patients (11%). In terms of etiological factors, 33 patients (22.5%) had infections. Food- related lesions were encountered in 14 (13%) patients. Thirty patients (28.5%) had history of medication use. Stress was detected in 37.1% of the patients; anxiety was diagnosed in 3% of patients. The stool was positive for parasites in 10 (9%) patients. Conclusion: Acute urticaria is a benign disorder. Although the underlying cause of urticaria can not always be identified, infections and medications are the most common causes. A comprehensive and detailed history is very important to discover the underlying cause. The diagnostic tests should be ordered according to the patient's history. Conducting diagnostic tests without considering the medical history of the patient leads to waste of time and resources. (Turkderm 2011; 45:179-83)
A Comparative Study of Histopathological Findings in Skin Biopsies From Patients With Psoriasis Before and After Treatment With Acitretin, Methotrexate and Phototherapy
(Taylor & Francis Ltd, 2015) Ozkanli, Seyma; Zemheri, Ebru; Karadag, Ayse Serap; Akbulak, Ozge; Zenginkinet, Tulay; Zindanci, Ilkin; Akdeniz, Necmettin
Introduction: Psoriasis is a chronic and inflammatory skin disease. Few studies in the literature evaluate the responses to the treatment histopathologically. Objectives: In this study, we evaluated and compared skin biopsies taken from patients with psoriasis before and after phototherapy and therapy with acitretin and methotrexate. Material and methods: We included 64 patients with a diagnosis of psoriasis vulgaris in our study. We performed phototherapy on 33 patients (51.6%), while 19 patients (29.7%) were treated with methotrexate and 12 patients (18.8%) were treated with acitretin. Results: All of the patients had chronic plaque psoriasis, and they had skin lesions on more than 10% of their total body surface area and a score of PASI of 7.2-21.8 (average: 12.2). The histopathological parameter scores were similar in the initial evaluations of the pre-treatment treatment groups. When the biopsy specimens of all cases were evaluated together, a significant decrease was observed in terms of parakeratosis, Munro's microabscesses, regular acanthosis, pustules of Kogoj, lymphocyte infiltration in the papillary dermis, loss of the granular layer, spongiosis, suprapapillary thinning, vascularity in the papillary dermis and neutrophile infiltration in the papillary dermis. Conclusion: We found in our study that conventional treatment modalities provided histopathologically significant recovery in psoriasis, but they did not have an effect on some histopathological findings. To our knowledge, it is one of the few studies to assess these parameters in psoriasis under the continuous effect of acitretin, methotrexate and phototherapy for three months. There is a need for studies with larger series to examine the histopathological effects of these treatment modalities in terms of immunopathology.
Comparision of Efficacy of Narrow Band Uvb, Calcipotriol-Narrow Band Uvb, Betamethasone-Calcipotriol- Narrow Band Uvb Combination Treatments in Vitiligo
(2009) Yavuz, İbrahim Halil; Akdeniz, Necmettin
Giriş: Vitiligo, akkiz, idiyopatik, net sınırlı depigmente maküllerle karakterize bir hastalıktır. Klinikte lokalize, jeneralize, üniversal ve karma tipleri görülmektedir. Jeneralize vitiligoda fotokemoterapi en sık kullanılan yöntemdir. Son yıllarda yan etkisi az olan dar band UVB tedavisinin daha etkili olduğu bildirilmektedir.Amaç: Bu çalışmada dar band UVB, kalsipotriol-dar band UVB ve dar band UVB-kalsipotriol-betametazon kombinasyon tedavilerinin etkinliğini araştırdık.Materyal ve Metod: Çalışmaya Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dermatoloji Anabilim Dalı Polikliniğine başvuran, nonsegemental vitiligo tanısı alan 45 hasta alındı. Hastalar 3 gruba ayrıldı. 1'inci grup betamatazon-kalsipotriol (Psorcutan beta® pomad)-dar band UVB ile tedavi edildi. 2'inci grup kalsipotriol (Psorcutan pomad®)-dar band UVB tedavisi 3. gruba ise sadece dar band UVB tedavisi uygulandı. Tedavi öncesinde her hastanın yaşı, cinsiyeti, mevcut lezyonların süresi, ailede vitiligo öyküsü hazırlanmış formlara kaydedildi. Hastalar haftada 3 seans şeklinde tedavi aldı. Vitiligo lezyonlarının fototipi bir olduğundan, hastaların deri fototipine bakılmaksızın tüm hastalarda başlangıç dozu 0.1 j/cm² şeklinde başlandı. Her seansta %10 oranında artırılarak 2.5 j/cm²'ye ulaşıldıktan sonra daha fazla arttırma yapılmadı. Hastaların tedavi öncesinde ve sonrasında psikososyal durumunu gösteren dermatoloji yaşam kalitesi formu ve görsel analog skalası formu düzenlendi.Bulgular: Hastaların yaşları 13 ile 55 (Ortalama 25.59) olarak saptandı. Hastalık süresi 3 ay ile 20 yıl arasında değişmekteydi. Tüm hastaların içinde aile öyküsü %22.2 oranında saptanmıştır (Ki-kare ( ? 2) = 0.257, p = 0.879 ). Tedaviden sonra düzelme oranları 1'inci grubun ortalaması %63.33±7.55, 2'inci grubun %60.67±5.75 ve 3 grubun ise %46.67±7.98 istatistiksel olarak anlamlı düzelme saptandı. Fakat gruplar arasında tedavi sonrası düzelme yüzdeleri açısından istatistik fark saptanmadı (p=0.221). Görsel analog skalası tedavi sonrasında 1'inci grupta ortalama değer 3.27±0.78, 2'inci grupta 3.20±0.56 ve 3'üncü grupta ise 4.07±0.78 olarak saptandı. Gruplar arasında görsel analog skalası tedavi sonrası değerleri açısından istatistiksel fark saptanmadı (p<0.01). Fakat grupların kendi içinde görsel analog skalası ortalama değerleri açısından istatistik olarak anlamlı düşüşler saptandı (p<0.01). Grupların kendi içinde Dermatoloji Yaşam Kalitesi İndeksi tedavi öncesi ve sonrası değerler açısında istatistik olarak anlamlı düşüşler saptandı. (p<0.01).Sonuç: Vitiligoda Dar band UVB ve kombine tedavileri etkili bulunmuştur. Tedavilerin dermatoloji yaşam kalitesi indeksinde belirgin düzelmeye neden olduğu görüldü. Fakat hastalığın kesin tedavisi için daha ileri çalışmalara ihtiyaç vardır.Anahtar sözcükler: Vitiligo, dar band UVB, kalsipotriol, betametazon
Comparison of Autologous Serum and Plasma Skin Tests in Patients With Chronic Urticaria
(2010) Aktar, Siraç; Akdeniz, Necmettin
Kronik ürtikerli hastalarda Otolog serum deri ve plazma deri testleri sonuçları arasındaki ilişkiyi değerlendirmek için 50 kronik ürtikerli hasta ele alındı ve sonuçları 20 sağlıklı birey ile karşılaştırıldı.Kronik ürtikerli hastalarda ve sağlıklı kontrol grubunda, her iki koldan uygulanan otolog serum ve plazmanın intradermal injeksiyonu ile oluşan eritemli papül çapı değerlendirildi. Sonuç olarak 50 KÜ'li hastanın 23'nde (%46) OSDT, 36'sında (%72) OPDT pozitif olarak saptandı. Sağlıklı kontrol grubunun 3'ünde (% 15) OSDT ve OPDT pozitif olarak saptandı. OPDT pozitifliği KÜ'li hastalarda OSDT'ye göre istatistiksel olarak anlamlı şekilde yüksek bulundu (p=0,001). Hem OSDT hem de OPDT pozitifliği KÜ'li hastalarda sağlıklı kontrol grubuna göre istatistiksel olarak anlamlı şekilde yüksek bulundu (sırasıyla p=0,015 ve p=0,000)KÜ olguları yaş, cinsiyet, hastalık süresi, ürtiker aktivite skoru, papül çapı açısından karşılaştırıldığında; OSDT pozitif hastalara göre oluşan papül çapı OPDT pozitif grupta daha fazla bulundu (p=0,000). OSDT ve OPDT pozitif hastalarda papül çapları bakımından kadınlar lehine anlamlı fark gözlendi (p<0,05)KÜ'li hastalarda yaş arttıkça OSDT ve OPDT pozitifliğinin arttığı şeklinde yorumlanan ve istatistiksel olarak desteklenen bulgulara rastlandı. ÜAS ve hastalık süresi açısından gruplar arasında anlamlı fark gözlenmedi.KÜ'li hastaların etyopatogenezinde otoimmüniteyi değerlendirirken OSDT'ye alternatif olarak OPDT uygulamasının daha etkili olduğunu düşünmekteyiz. Bu uygulama ileri çalışmalarla desteklendiğinde, pıhtılaşma faktörlerinin rolleri tam olarak belirlenip hastalıkta yeni ufuklar ve tedavi alternatifleri doğuracaktır.
Comparison of Efficacy of Narrow Band Uvb Therapies With Uvb Alone, in Combination With Calcipotriol, and With Betamethasoneand Calcipotriol in Vitiligo
(Taylor & Francis Ltd, 2014) Akdeniz, Necmettin; Yavuz, Ibrahim Halil; Bilgili, Serap Gunes; Yavuz, Goknur Ozaydin; Calka, Omer
Objective: The purpose of this study is to compare the efficacy of three therapies in the treatment of non-segmental vitiligo: a combination of topical calcipotriol, narrowband-ultraviolet B (NB-UVB), and betamethasone therapies; a combination of NB-UVB and topical calcipotriol; and NB-UVB alone. Material and methods: Forty-five patients with non-segmental vitiligo presenting to our Dermatology clinic were recruited to participate in the study. Patients were randomly divided into three groups. For each patient the size of the depigmented areas was assessed according to the rule of nines. The first group was treated with a combination of topical calcipotriol, NB-UVB, and betamethasone therapies. The second group was treated with a combination of NB-UVB and topical calcipotriol and third group was treated with NB-UVB alone. Since the patients' vitiligo lesions had similar phototypes, all patients were started with 0.1 j/cm(2), regardless of their skin phototype. The dose of NB-UVB was increased 10% in each session and no further increment was done after reaching 2.5 j/cm(2). Treatment effectiveness was evaluated according to the percentage improvement in repigmentation. The quality of life of the patients was measured by the Dermatology Life Quality Index (DLQI). Results: The patients were aged from 13 to 55 years (mean: 25.29). The duration of disease ranged from 3 months to 20 years. Family history was positive for vitiligo in 10 patients (22.2%). The percentage of recovery after treatment was 63.33% +/- 7.55 in group 1, 60.67% +/- 5.75 in group 2, and 46.67% +/- 7.98 in group 3. There was no statistically significant difference between groups 1 and 2, and groups 2 and 3, but there was a statistically significant difference between groups 1 and 3 (p = 0.0048). Conclusions: In conclusion, NB-UVB-alone therapy and the combined therapies are effective treatment options in the treatment of vitiligo. Future studies with larger groups are warranted to confirm our results.
Comparison of Tyrosinase Antibody, Tyrosinase-Related Protein-1 And-2 Antibodies, Melanin-Concentrating Hormone Receptor Antibody Levels With Autologous Serum Skin Test and Autologous Plasma Skin Test Results in Patients With Vitiligo
(Termedia Publishing House Ltd, 2021) Unal, Abdullah; Ozkol, Hatice Uce; Bayram, Yasemin; Akdeniz, Necmettin
Introduction: Although the exact etiopathogenesis of vitiligo is unknown, the autoimmunity hypothesis is much in evidence. The autologous serum skin test (ASST) and autologous plasma skin test (APST) are in vivo methods used in the diagnosis of some autoimmune diseases, which are easy and inexpensive to perform. Aim: In this study, we investigated whether or not ASST and APST could determine autoimmunity in patients with vitiligo. Material and methods: In this study, 30 vitiligo patients presenting to the dermatology outpatient clinic and 30 healthy volunteers without any known autoimmune diseases were included. Antibodies such as tyrosinase, tyrosinase-related protein-1 (TYRP1), tyrosinase-related protein-2 (TYRP2) and melanin-concentrating hormone receptor 1 (MCHR1) antibodies determined to be associated with vitiligo were examined. In addition, the association of these antibodies with the positivity of ASST and APST, which were suggested to be associated with autoimmunity, were examined. Results: In our study, tyrosinase antibody was found to be significantly higher in vitiligo patients. ASST was positive in 12 (40%) patients with vitiligo and 8 (26.6%) control subjects. APST was positive in 8 (26.6%) of the patients with vitiligo and in 2 (6.6%) of the controls, and there was a significant difference between the groups in terms of APST positivity (p = 0.032). In addition, in our study, a significant correlation was found between TYRP1 antibody positivity and APST positivity in the patient group (p = 0.005). Conclusions: These findings suggest that we may use APST to investigate the autoimmune etiopathogenesis of vitiligo.
Cutaneous Anthrax Resulting in Renal Failure With Generalized Tissue Damage
(Taylor & Francis Ltd, 2013) Akdeniz, Necmettin; Calka, Omer; Ozkol, Hatice Uce; Akdeniz, Hayrettin
Anthrax is a zoonotic infection caused by Bacillus anthracis which can be clinically present in a cutaneous, gastrointestinal or inhalational form depending on the entry site of the agent. The most frequent clinical type with the mildest clinical course is cutaneous anthrax. In this report, a patient with cutaneous anthrax which begins at the dorsal hand and progresses up to the proximal forearm resulting in massive tissue damage is presented. Prerenal azotemia developed due to massive tissue damage and patient was sent to hemodialysis twice.
Deri Hastalıklarının Tanısında Histopatolojinin Yeri
(2005) Akdeniz, Necmettin; Metin, Ahmet; Çalka, Ömer; Kösem, Mustafa; Uğraş, Serdar; Bayram, İrfan
Amaç: Deri hastalıklarının tanısı, yalnızca klinik gözlemlere değil, histopatolojik bulgulara da bağlıdır. Bu çalışmada klinik ön tanı ile patolojik tanıların uyumunun incelenmesi amaçlandı. Gereç ve Yöntem: Dermatoloji kliniği tarafından alınarak patoloji laboratuvarına gönderilen 460 deri biyopsisi, geriye dönük olarak incelendi. Bulgular: Biyopsilerin 139 tanesi (%30.2) patolojiden doğrudan tanı almadan ve yorum yapılarak rapor edilmişti. Tanı alan 321 olgunun 159'u (%49.5), dermatoloji kliniğinin birinci, 43'ü (%13.8) ikinci, 14'ü (%4.3) üçüncü ve 63'ü de (%19.6) ilk üç ön tanı dışında kalan ön tanılar ile uyum gösterirken geriye kalan 42 (%13.4) biyopside patolojinin tanıları dermatoloji kliniğinin ön tanıları ile uyumlu değildi. Sonuç: Dermatoloji ile patoloji arasında uygun bir klinikopatolojik korelasyon doğru tanı koyma oranını yükseltecektir.
Development of Phytophotodermatitis in Two Cases Related To Plantago Lanceolata
(Taylor & Francis Ltd, 2012) Ozkol, Hatice Uce; Akdeniz, Necmettin; Ozkol, Halil; Bilgili, Serap Gunes; Calka, Omer
Plantago lanceolata, also known as snake's tongue, is a perennial herbaceous plant from the family Plantaginaceae. It is a species widely distributed both in Turkey and all over the world. Today, its fresh leaves are still used to soothe and suppress cough, externally for wound healing and draining abscesses. Phytophotodermatitis (PPD) is a dermal photosensitive reaction induced by the contact to or oral intake of a plant and subsequent exposure to sunlight. Its acute course is called phototoxic. In this paper, two cases developed phototoxic reaction with the consumption of Plantago lanceolata and subsequent exposure to the sunlight. These cases were presented since such effect of the plant has not been known previously and there is no resembling case in the literature.
Dudak Ve Dilde Yerleşen Lenfanjioma Sirkumskriptum
(2002) Metin, Ahmet; Çankaya, Hakan; Kösem, Mustafa; Akdeniz, Necmettin; Çalka, Ömer
Lenfanjioma sirkumskriptum, deriyi tutan ve alttaki subkütan yağ dokusuyla kaslara da yayılabilen lenfatik bir malformasyondur. Nadir rastlanan dil ve dudak tutulumu ile seyreden 14 yaşındaki erkek hasta sunulmuştur.
Early Development of Squamous Cell Carcinoma in Two Sister Cases With Epidermodysplasia Verruciformis
(deri Zuhrevi Hastaliklar dernegi, 2010) Calka, Oemer; Bilgili, Serap Guenes; Akdeniz, Necmettin; Bayram, Irfan
Epidermodysplasia verruciformis (Lewandowsky-Lutz syndrome) is an uncommon disease characterized by multiple plane warts, pityriasis versicolor-like lesions, defects of cell-mediated immunity, and tendency to develop skin malignancies, primarily on sun-exposed areas. Most commonly it is inherited as an autosomal recessive trait. Squamous cell carcinoma is the most common type of skin cancer found in patient with epidermodysplasia verruciformis. Human papilloma virus 5, 8, and 47 are found in more than 90% of epidermodysplasia verruciformis skin cancers. Treatment for epidermodysplasia verruciformis consists largely of preventive measures. Photoprotection remains essential for management. In this report, two sister case of epidermodisplasia verruciformis with plane warts, pityriasis versicolor-like lesions, and squamous cell carcinomas on sun-exposed areas of skin was presented for it is a rarely encountered disease and associated with early development of malignancy. (Turkderm 2010; 44: 92-5)
Effect of Probiotics on the Treatment of Children With Atopic Dermatitis
(Korean dermatological Assoc, 2012) Yesilova, Yavuz; Calka, Omer; Akdeniz, Necmettin; Berktas, Mustafa
Background: Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic dermatitis. Objective: In this double-blind, randomized, placebo-controlled study, a combination of Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus salivarius strains were evaluated in the treatment of atopic dermatitis in pediatric patients. Methods: Forty pediatric patients (23 males and 17 females) aged 1 similar to 13 years were enrolled. One eligible individual who was approached declined to participate. The probiotic group was administered a probiotic complex containing B. bifidum, L. acidophilus, L. casei, and L. salivarius for 8 weeks. The placebo group, on the other hand, was administered skim milk powder and dextrose. All of the parameters including serum cytokines, eosinophil cationic protein), SCORing Atopic Dermatitis (SCORAD) index, and total serum immunoglobulin E (IgE) were measured in both the probiotic group and the placebo group at the end of 8 weeks. Results: Probiotic intervention in pediatric atopic dermatitis patients effectively reduced the SCORAD index and serum cytokines interleukin (IL)-5, IL-6, interferon (IFN)-gamma, and total serum IgE levels, but did not reduce levels of serum cytokines IL-2, IL-4, IL-10, ECP, or tumor necrosis factor-alpha (TNF-alpha) compared to the placebo group. Conclusion: Our study found probiotics to be effective in reducing atopic dermatitis patients' SCORAD index, serum IL-5, IL-6, IFN-gamma, and total serum IgE levels but not effective in reducing serum IL-2, IL-4, IL-10, ECP, or TNF-alpha levels. (Ann Dermatol 24(2) 189 similar to 193, 2012)