Browsing by Author "Akgul, Yakup"

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Determination of Selected Hormones and Biochemical Parameters in Turkish Van Cats With Tail Gland Hyperplasia
(Polish Soc veterinary Sciences Editorial office, 2020) Ozkan, Cumali; Kayar, Abdullah; Kaya, Abdullah; Yildirim, Serkan; Iskefli, Onur; Kozat, Suleyman; Akgul, Yakup
The present study was performed on Turkish Van cats with tail gland hyperplasia in order to determine changes in some hormone levels and biochemical parameters. Animal material consisted of 18 male Van cats of between 2-8 years of age, 12 with tail gland hyperplasia and 6 unaffected cats as the control group. Following routine clinical examination, hormone levels and biochemical parameters were measured by obtaining blood samples, and biopsy samples were obtained from the region and examined under a light microscope. When compared with the control group, testosterone levels were high although the difference between groups was not statistically significant. Similarly, no statistical significance was found between the groups in terms of other hormones. Among the hormonal parameters, the only remarkable increase was seen in the testosterone level. Among biochemical parameters, the alkaline phosphatase (ALP), aspartate amino transferase (AST), cholesterol and triglyceride levels were statistically different, while other biochemical parameters were not statistically significant. While AST and cholesterol results were increased, ALP and triglyceride levels were decreased. As a result, we conclude that the disease is an important problem which occurs extensively in mature male Van cats, particularly during and after mating periods. We also conclude that the disease might be associated with an increase in testosterone levels. Presenting this study is beneficial as there are limited reports about this disease in cats. This is the first study presenting tail gland hyperplasia with some hormonal levels and biochemical parameters in male Van cats.
Diagnosis and Treatment of Hypophosphatemia in Young Turkeys
(Univ Agriculture, Fac veterinary Science, 2012) Ozkan, Cumali; Kaya, Abdullah; Aslan, Logman; Akgul, Yakup
This study was aimed to diagnose and to treat the disease of young turkeys showing hypophosphatemia symptoms in a farm. The material of this study was consisted of turkeys in both sexes, aged between 13-15 weeks. In the clinical examinations of the turkeys; weight loss, weakness, unwilling to walk, lameness and extremity fractures in some animals were determined. Blood samples were collected from 20 turkeys chosen randomly for biochemical analyses and mineral assays. Serum Ca, P, ALP, Mg, Cu, Zn, Fe, Mn and Co levels were analyzed. Phosphorus and Zn levels were found to decrease significantly whereas Ca, ALP, Mn levels and Ca/P ratio found to increase before treatment. For treatment purpose, phosphoric acid and vitamin D-3 were added to their drinking water. Clinical findings improved after treatment and biochemical parameters which were abnormal before treatment returned to normal values after treatment. As a result, hypophosphatemia was one of the most important reasons of foot problems and bone fractures during the growth period of the turkeys. It was also observed that adding phosphorus and vitamin D-3 in the drinking water for the purpose of treatment was considered to be beneficial. (C) 2011 PVJ. All rights reserved
Evaluation of Acute Phase Protein Levels and Some Cytokine Levels in Pneumonic Calves
(Polish Soc veterinary Sciences Editorial office, 2019) Akgul, Omer; Kozat, Suleyman; Ozkan, Cumali; Kaya, Abdullah; Akgul, Yakup
This study was carried out to determine the levels of various cytokines (TNF-alpha, IL-6, IL-8) and acute phase proteins (haptoglobin, C-reactive protein, serum amyloid A, alpha 1-acid glycoprotein, lactoferrin, and fibrinogen) in pneumonic calves, to reveal changes in these parameters depending on etiologic factors (bacterial, viral, bacterial + viral) in calf pneumonia, and to determine whether these parameters could be used for diagnosis and prognosis of the disease. The study was carried out on a total of 50 calves consisting of 10 healthy and 40 pneumonic animals aged 1 to 6 months. The pneumonic calves were classified into three groups: bacterial, viral and mixed (bacterial + viral). It was found that the levels of IL-6, IL-8, CRP, and TNF-alpha were statistically higher in the pneumonic calves than in the control group animals. It was found that the increase in levels of Serum IL-6, IL-8, and CRP were highest in the mixed infection group (bacterial + viral) and lowest in the virally infected group. Similarly, serum levels of Hp, CRP, SAA, alpha-1-AGP, and LF were found to be more statistically significant (P <0.01) in the infected calves than in the control group animals, but changes in fibrinogen levels were not statistically significant. Although the TP and ALB levels in the pneumonic calves were numerically higher than the same parameters in the control group, this was not statistically significant (P> 0.05). As a result, this study showed that serum levels of cytokines (IL-6, IL-8, TNF-alpha) and serum concentrations of acute-phase proteins (Hp, CRP, SAA, alpha-1-AGP, and LF) are significantly higher in the pneumonic calves than in the control group calves. Furthermore, the assessment of cytokine and acute phase protein levels can play an important role in the early diagnosis of calf pneumonia. This early diagnosis can help prevent deaths caused by pneumonia, which is the leading cause of major losses, and can also be helpful in the early treatment of pneumonia in the veterinary clinical field.
Measurement of M-Mode Echocardiographic Parameters in Healthy Adult Van Cats
(Hokkaido Univ, 2014) Kayar, Abdullah; Ozkan, Cumali; Iskefli, Onur; Kaya, Abdullah; Kozat, Suleyman; Akgul, Yakup; Or, Mehmet Erman
Cardiomyopathies are the most common type of cardiac diseases in cats. Although some normal echocardiographic values for cats have been published, there are variations based on breeds and gender. The objective of this study is to determine normal reference values for M-mode echocardiographic parameters in nonsedated healthy adult Van cats and to compare those values with data reported for nonsedated healthy cats of other breeds. A total of 40 clinically healthy Van cats of both sexes belonging to the Van Cat Research and Application Center of Yuzuncu Yil University were used. Body weight (BW) and 16 M-mode echocardiographic variables were measured in 40 healthy Van cats. The effect of gender and age on each echocardiographic parameter was analyzed and the relationship between BW and each parameter investigated. There was a significant relationship between gender and left atrial dimension during ventricular systole (LAD) and aortic root dimension at end-diastole (AOD) as well as between BW and interventricular septal thickness at end-diastole (IVSd) and end-systole (IVSs), left ventricular internal dimension at end-diastole (LVIDd), left ventricular posterior wall thickness at end-diastole (LVPWd), LAD, AOD, the left ventricular end diastolic volume (EDV) and the stroke volume (SV). A relationship between age and the SV parameter alone was also established. This present study is the first work on cardiac reference values for Van cats highlighting the differences in some M-mode echocardiographic parameters of healthy adult Van cats and other cat breeds, which should be considered when interpreting echocardiographic findings, in order to draw the correct conclusions regarding cardiac health.
Medical and Surgical Treatment of Gastric Impaction in Juvenile Ostriches
(Medwell online, 2009) Aslan, Logman; Karasu, Abdullah; Ozkan, Cumali; Duz, Erkan; Kaya, Abdullah; Akgul, Yakup
Radiological diagnosis and medical and surgical treatment options of the constipation problem seen in ostrich chicks were investigated in this study. The study was performed in a farm that 60 ostrich chicks were kept that are between 8 and 12 weeks of age. Our clinic was applied to upon seeing loss of appetite, weight loss and sudden death in 2 animals in the farm. Fifteen sick ostrich chicks that gastric impaction problem was found with clinical and radiological examination were included in the study. In the ostrich chicks that were found to be sick in clinical examination, clinical symptoms were observed like loss of appetite, weakness, dehydration, reduced number of defecations, drooping wings, messiness of feathers and inability to stand. Medical treatment was applied to 7 animals that general health status was not severe and that obstruction was found to be not complete in radiological examination and proventriculotomy operation was performed in 8 animals that stomachs were found to be full with foreign materials in radiological examinations and with serious health condition and also in 2 ostrich chicks that did not respond to medical treatment. Five patients out of 7 that medical treatment was applied and 8 patients out of 10 that were treated surgically responded to the treatment and got well. In the autopsies of the animals that did not respond to the treatment and died, macroscopic edema, erosion and hemorrhagic ulcers were found in proventriculus and ventriculus mucosa and in addition, stomach was filled with stones, sand, pieces of wood, metal and glass, rough feed particles and clover fibers. It was concluded that radiological examination will determine the level of obstruction, make the treatment easier and will direct it. It was also, concluded that emergency surgical treatment in cases with complete obstruction not responding to medical treatment would be beneficial if performed with no time loss.
Relationship Between Packed Cell Volume Levels and Serum Nitric Oxide Concentrations in Cattle With Tropical Theileriosis
(Univ Agriculture, Fac veterinary Science, 2015) Ozkan, Cumali; Altug, Nuri; Akgul, Yakup; Keles, Ihsan; Kaya, Abdullah; Yuksek, Nazmi; Yur, Fatmagul
This study was performed to determine changes in serum NO (nitric oxide) levels in cattle with theileriosis in accordance with PCV levels. For this purpose, 42 cattle with theileriosis and 10 healthy cattle have been used as material. Infected animals have been divided into 3 equal groups. 1st group had <12%, 2nd group had 13-24% and 3rd group had <25% PCV level. Blood samples have been used to determine NO concentrations. Serum NO concentrations prior to treatment increased in all infected groups compared to control group however its levels were significant only in the third group. NO concentrations decreased to almost normal values after treatment especially in 2nd and 3rd group, however this decrease was not significant in the first group. As a result, NO levels have been found increased in cattle with natural theileriosis. Therefore, its concluded that NO level and PCV levels in theileriosis should be studied with more detail in the future to enlighten the role of NO release and strategies for controlling its' release should be made especially in severe cases. (C)2015 PVJ. All rights reserved
Serum Homocysteine, Vitamin B12 and Folate Levels in Healthy Turkish Van Cats
(Network veterinarians Bangladesh, 2017) Ozkan, Cumali; Kozat, Suleyman; Kaya, Abdullah; Akgul, Yakup
Objective: The present study was conducted for the purpose of setting forth the normal serum Hcy, vitamin B-12 and folate levels in Van cats of varying ages and genders, and the age-dependent variations of these parameters. Materials and methods: The material of the study consisted of a total of 60 healthy Van cats including 30 female and 30 male cats. Cats from both genders were separated into 3 groups on the basis of their ages. While the cats of 6 - 12 months of age were included in the first group, cats of 12-24 months of age were included in the second and those of more than 24 months of age were included in the third group. Results: From the blood samples collected; serum normal homocysteine, vitamin B-12 and folate levels were determined as 7.1 +/- 2.2 nmol/mL, 850.7 +/- 231.8 pg/mL and 16.7 +/- 0.8 ng/mL, respectively. In the statistical comparison of the determined serum homocysteine, vitamin B-12 and folate levels; some variations among different groups of age and genders were determined. However, none of these differences were determined to be statistically significant. Conclusion: The normal levels of serum Hcy, vitamin B-12 and folate of healthy Van cats were set forth for the first time by the present study. It is believed that the normal values of these parameters in Van cats can be used in the diagnosis and prognosis of various diseases and particularly cardiovascular diseases, that they will be helpful for researchers and will serve as a guideline to the studies to be conducted in the future.