Browsing by Author "Akgun, C."

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Brucellosis as a Trigger Agent for Henoch-Schonlein Purpura
(Comenius Univ, 2012) Akgun, C.; Akbayram, S.; Guner, S.; Aktar, F.; Temel, H.; Basaranoglu, M.
Vasculitis in childhood is a result of a spectrum of causes ranging from idiopathic conditions with primary vessel inflammation to syndromes after exposure to recognized antigenic triggers, such as infectious agents and drugs causing hypersensitivity reactions. Henoch-Schonlein purpura (HSP) is the most common vasculitis of childhood. Although there is often a history of a recent or simultaneous upper respiratory tract infection, no consistent causative organism is found. We report an 11-year old boy with HSP and brucellosis and we speculated that brucellosis was the trigger agent for HSP (Ref. 13). Full Text in PDF www.elis.sk.
A Case of Langerhans Cell Histiocytosis With Anal Fistula
(Kurume University School of Medicine, 2010) Akbayram, S.; Akgun, C.; Ozen, S.; Kaya, A.; Tuncer, O.; Yuca, S.A.; Oner, A.F.
Langerhans cell histiocytosis (LCH) is an uncommon clinically heterogeneous disorder characterized by the proliferation and accumulation of Langerhans cells with local infiltration of tissues and organ destruction. LCH takes many clinical forms, affecting different systems and different sites in the same system with variable outcomes. Bone, skin, lymph node, pituitary, liver, lung, bone marrow and spleen involvement can be seen in patients with LCH. Involvement of the perianal site is rare. In this article, a 16-month-old boy with multiple organ involvement including skin, liver, lung, and bone is presented. Aside from these systemic involvements, he also had a simple anal fistula. According to our best knowledge, this case of LCH with anal fistula is only the second to be reported in childhood. We would like to emphasize that LCH may be associated with anal fistula; therefore, we suggest that patients with LCH should be examined for this condition.
A Case of Scrotal Swelling Mimicking Testicular Torsion Preceding Henoch-Schonlein Vasculitis
(Comenius Univ, 2012) Akgun, C.
Henoch-Schonlein purpura, is one of the most common types of multisystemic vasculitis seen in The major clinical manifestations are cutaneous purpura, arthritis, abdominal pain, gastrointestinal bleeding, and nephritis. Isolated central nervous system vasculitis, seizures, coma and hemorrhage, Guillan-Barre syndrome, ataxia and central and peripheral neuropathy, ocular involvement, orchitis, epididymitis or testicular torsion are medical or surgical complications. In this study, we report a 7-year-old boy with scrotal swelling mimicking testicular torsion with ultrasonographic and clinical findings that the typical clinical features of Henoch-Schonlein purpura including rashes and arthritis were developed after one week of surgery (Ref. 15). Full Text in PDF www.elis.sk.
Ceftriaxone Induced Thrombocytopenia in a Child
(Comenius Univ, 2011) Akbayram, S.; Akgun, C.; Dogan, M.; Caksen, H.; Oner, A. F.
A variety of diseases, hereditary conditions, toxins and drugs may cause thrombocytopenia. Thrombocytopenia induced by ceftriaxone has been rarely reported. In this case, ceftriaxone-induced thrombocytopenia is presented in a 2-year-old girl due to rare presentation (Ref. 10). Full Text in free PDF www.bmj.sk.
Central Nervous System Involvement in a Case of Familial Hemophagocytic Lymphohistiocytosis With Perforin Mutation
(Medecine Et Hygiene, 2011) Akbayram, S.; Akgun, C.; Dogan, M.; Caksen, H.; Okur, H.; Oner, A. -F.
Central nervous system involvement in a case of familial hemophagocytic lymphohistiocytosis with perforin mutation: Familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive lethal condition characterized by fever, cytopenia, hepatosplenomegaly and hemophagocytosis. The presence of central nervous system involvement has a profound impact on the prognosis, treatment, and clinical outcome of the disease. Therefore, the identification of the clinical manifestations of the disease and the characterization of the accompanying neurological symptoms are of prime importance for the rapid diagnosis and subsequent clinical management of the disease. Herein, we report a case of FHL with homozygosity for perforin gene mutation, who presented with central nervous system involvement in the absence of systemic findings.
Chondrodysplasia Punctata Associated With Tetralogy of Fallot in a Newborn Infant
(Medecine Et Hygiene, 2010) Akgun, C.; Akbayram, S.; Tuncer, O.; Taskin, G.; Ceylan, A.
The Frequency of Consanguineous Marriage in Eastern Turkey
(Medecine Et Hygiene, 2009) Akbayram, S.; Sari, N.; Akgun, C.; Dogan, M.; Tuncer, O.; Caksen, H.; Oner, A. F.
The frequency of consanguineous marriage in Eastern Turkey: Objective: The rate of consanguineous marriage (CM) varies depended on different factors such as race, characteristics of population, and religion and moral features in different countries. Gene frequency and genetic structure are changed by CMs. The aim of the present study is to assess the prevalence of CM and its effects on miscarriage, stillbirth, congenital malformation and ratio of newborn death. Methods: This study was performed in Van region, Eastern Turkey, between September 2005 and April 2006. A total of 650 families from 24 districts chosen in accordance with the number of inhabitants were included in this study. First cousin marriages were accepted as a first degree CMs, sesquialter and second cousin marriages as second degree and marriages between distant relatives were accepted as a third degree CM. Monthly income of the families was classified in accordance with minimum wage determined by government. Results: Of all families, 224 (34.4%) had CM, and 168 (75%) had first-degree consanguinity. A lower CM rate was found in mothers who graduated from secondary school or upgrading (p <0.01). However, no relationship was found between CM and fathers' education level. While a low CM rate was found in families who had two or less children (p <0.01), high rate was observed in families who had five or more children. In addition, a high rate of miscarriage, stillbirth and mental-motor retardation was found in families with CM (p <0.05). The rate of child mortality between the aged 0-2 years was found to be higher in families with CM (p <0.01). The higher CM rate was observed in families who married due to pressure or insistence of their families than married voluntarily (p <0.05). Conclusion: Our study showed that CM rate was very high, 34.4%, in our region Eastern Turkey.
Giant Cavernous Hemangioma in Two Neonates With Kasabach-Merritt Syndrome: Successful Management With Interferon Alpha and Prednisolone
(Blackwell Publishing, 2008) Kirimi, E.; Tuncer, O.; Akgun, C.; Ceylan, A.
The Incidence of Asymptomatic Hypertension in School Children
(2010) Akgun, C.; Dogan, M.; Akbayram, S.; Tuncer, O.; Peker, E.; Taşkin, G.; Arslan, D.
Background: Although hypertension is a well-documented risk factor for cardiovascular diseases, including myocardial infarction and stroke, in adults, only recently has knowledge about childhood hypertension increased significantly. Aim: To determine the incidence of asymptomatic hypertension in school-age children. Subjects and Methods: Children in primary school were chosen with a randomized sampling method. During measurement of blood pressure, a calm, comfortable setting was provided. Blood pressure measurements were performed by only 1 researcher. For accurate measurement of blood pressure, recommended standards were followed. Results: A total of 1,963 children were included in the study. The incidence of systolic hypertension and diastolic hypertension were 7% and 2%, respectively. Obesity was present in 10.5% girls with hypertension and 13.9% of boys with hypertension. Conclusion: Our findings indicate that hypertension is an important health problem in children, and its prevalence is quite high. Blood pressure measurements must be a part of routine clinical examinations. Further studies should be performed in high-risk populations to prevent hypertension and to establish methods of early diagnosis and treatment in children.
Report of a Girl With Vacterl Syndrome and Right Pulmonary Agenesis
(Medecine Et Hygiene, 2009) Avcu, S.; Akgun, C.; Temel, H.; Arslan, S.; Akbayram, S.; Unal, O.
Report of a girl with VACTERL syndrome and right pulmonary agenesis: VACTERL syndrome is a combination of vertebral anomalies (V), anal atresia (A), congenital heart defects (C), tracheo-esophageal fistula (T), esophageal atresia (E), abnormalities of kidneys (renal anomalies, R) and limbs (L). In the present patient right pulmonary agenesis is co-occurring with VACTERL syndrome. We report on this case because the association of right pulmonary agenesis and VACTERL syndrome is rare.
T-Cell Lymphoblastic Leukemia as a Rare Cause of Bilateral Nephromegaly
(2012) Akbayram, S.; Akgun, C.; Peker, E.; Bulut, M.D.; Aktar, F.; Oner, A.F.