Browsing by Author "Akgun, E."

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The Activities of Serum Paraoxonase and Arylesterase and Lipid Profile in Acute Myeloid Leukemia: Preliminary Results
(verduci Publisher, 2015) Cebi, A.; Akgun, E.; Esen, R.; Demir, H.; Cifci, A.
OBJECTIVE: To investigate the activities of serum paraoxonase-1 (PON1) and arylesterase (ARE), and the lipid profile in newly diagnosed acute myeloid leukemia (AML) patients. PATIENTS AND METHODS: Thirty-two persons (16 of AML and 16 of healthy control) were included to the study. PON1 and ARE activities were measured as spectrophotometrically in serum samples. High density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG) were analyzed in autoanalyzer. RESULTS: PON1 activities were respectively 16.04 U/L and 18.6 U/L in AML and healthy controls. There was no statistical significance between groups (p > 0.05). The mean ARE activities were respectively 0.21 U/L and 0.36 U/L in AML and healthy controls. Serum ARE activity significantly decreased in AML group (p < 0.001). Serum HDL values were significantly decreased (181.8 +/- 76.2 mg/dl; p = 0.002) in AML. There was no difference in total cholesterol, LDL and triglyceride values (respectively; 181.8 +/- 76.2 mg/dl, 120.6 +/- 64.6 mg/dl, 157.3 +/- 87.2 mg/dl; p > 0.05) between AML and controls. CONCLUSIONS: This is the first documented study about serum PON1 activity in AML patients. Although serum PON1 activities were not changed in both groups, our data suggest that the decreased serum ARE activity and HDL levels may be related the pathogenesis of AML.
Functional and Radiological Out Comes of Patients With Full-Thickness Rotator Cuff Tears Repaired by Arthroscopic Knotted-Suture Bridge Double Row Method
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Akgun, E.; Tepedelenlioglu, H.E.; Kurdal, D.P.; Adanas, C.; Akpolat, A.O.
Introduction: To evaluate the functional and radiological results of double-row arthroscopic rotator cuff repairs performed by the Knotted Suture Bridging method. Materials and Methods: The study included 36 patients. Before surgery, tear type, tear size, and muscle atrophy were examined by ultrasound (USG) and magnetic resonance imaging (MRI) in all patients. In the clinical evaluation, the preoperative and posto perative 2nd year results of the patients were compared by Visual Analogue Scale (VAS), scoring the University of California, Los Angeles (UCLA) and the shoulder index scoring of the American Shoulder and Elbow Surgeons (ASES). Sugaya MRI recovery analysis was used to evalu ate the structural healing of the tendon. Results: A significant decrease was found in the patients' VAS scores in the postoperative period. While the preoperative UCLA (0-35) score was 19.1, the median value in the second postoperative year was 29.7. (p<0.001). The median preoperative ASES index (0-100) was 46.7 before and 85 after surgery. (p<0.001) Both scores show a significant improvement in patients in the second postoperativ e year. MRI imaging showed good rotator cuff healing in 29 patients (Sugaya type 1-2), Sugaya type 3 in 2 patients, type 4 lesions in 2 patients, and type 5 in 3 patients. Conclusion: Double-row arthroscopic rotator cuff repairs performed by the Knotted Suture Bridging method in medium and large rotator cuff tears are highly effective in the tendon's functional and adhesive healing. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
May Supplementation of Coenzyme Q10 Help Prevent Development of Hydatidiform Mole
(7847050 Canada inc, 2017) Kolusari, A.; Cebi, A.; Akgun, E.; Alp, H. H.; Bakan, E.
Objective: The pathological mechanisms of gestational trophoblastic disease have not yet been clearly determined. It is thought that oxidative damage contributes to the process. The aim of this study was to determine the levels of coenzyme Q10 (CoQ10), DNA damage, and lipid peroxidation in patients with hydatidiform mole. Materials and Methods: The authors studied the levels of CoQ10, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA) by high-performance liquid chromatography (HPLC), and the activity of glutathione peroxidase (GPX) by spectrophotometric method in blood obtained from patients with a complete hydatidiform mole (n=29), healthy pregnant women (n=29), and healthy non-pregnant women (n=29). Results: The 8-OHdG/dG ratio (2.8148 +/- 0.81592) and MDA (10.8341 +/- 4.64875 mu mol) were significantly higher in patients with complete hydatidiform mole, while the ubiquinol-10/ubiquinone-10 ratio (0.2107 +/- 0.15675) and GPX activity (43.4606 +/- 18.31694 mU/ml) were lower (p < 0.001). Conclusion: The authors suggest that both mitochondrial oxidative and oxidative DNA damage play important roles in the pathogenesis of complete hydatidiform mole. Therefore supplementation of CoQ10 prevents recurrent gestational trophoblastic disease.