Browsing by Author "Akkol, E."

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Assessment of Antidepressant Effect of the Aerial Parts of Micromeria Myrtifolia Boiss. & Hohen on Mice
(NLM (Medline), 2019) Akkol, E.; Gürağaç Dereli, F.T.; İlhan, M.
The currently available antidepressant agents necessitate the development of newer alternatives because of their serious adverse effects and costs. Traditional medicinal knowledge is likely the key that opens the door to discover new medicines. In Turkish folk medicine, the infusion prepared from aerial parts of Micromeria myrtifolia Boiss. & Hohen is used as pleasure and medicinal tea for its relaxing action. The present research was conceived to confirm the antidepressant's potential of this traditional medicinal plant. In this process, first of all, the collected and shade-dried aerial parts of M. myrtifolia were powdered and then, extracted using solvents with different polarity as follows; n-hexane, ethyl acetate (EtOAc), and methanol (MeOH). The antidepressant activity of the extracts was evaluated by using several in vivo and in vitro experimental models of depression. When the data obtained from the control and experimental groups were compared, it was determined that the MeOH extract was the most active. The active components of this extract were isolated and identified utilizing various chromatographic separation techniques. The MeOH extract was applied to reversed phase (RP-18) column chromatography to obtain five main fractions and they were tested on antidepressant activity models. The isolated compounds from the obtained fractions were elucidated as rosmarinic acid (1), myricetin (2), apigenin (3), and naringenin (4) which were assumed to be responsible for the antidepressant activity of the aerial parts. According to the results, rosmarinic acid, myricetin, apigenin, and naringenin showed statistically significant activity on forced swimming test and tetrabenazine-induced ptosis models, whereas only rosmarinic acid showed statistically significant activity on the tail suspension test. Apigenin displayed the highest inhibitory activity on MAO A and B enzymes. Studies in the future should be performed to investigate the antidepressant activity mechanism of these natural compounds. The current research could be an important step in the development of the new agents that can be used in the treatment of depression. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
The Effect of Solution and Gel Forms of Sodium Hypochlorite on Postoperative Pain: a Randomized Clinical Trial
(Faculdade De Odontologia De Bauru, 2021) Ozlek, E.; Gunduz, H.; Kadi, G.; Taşan, A.; Akkol, E.
Objectives: The aim of this study is to evaluate the effect of using gel and solution forms of NaOCI during the chemomechanical preparation of the root canals on postoperative pain at different time intervals. Methodology: 114 patients with mandibular molar teeth and symptomatic irreversible pulpitis were included in the study. All patients were divided into two groups based on the irrigant used during root canal preparation (n=57): Group 1, 5.25% NaOCI, Group 2, 5.25% NaOCI gel. All groups were filled with gutta-percha and AH Plus root canal sealer using single-cone technique. VAS scale (1-10) was used for postoperative pain assessment. After endodontic treatment, all patients were asked to record their postoperative pain levels at the 6th, 24th, 48th, 72nd hours, and 1 week later. The data were analyzed using Chi-Squared, Independent Samples T, Cochran Q and Friedman tests. Results: Statistically significant difference was not found between the distributions of pain levels at different times according to the groups (p>0.050). A statistically significant difference was observed between the distributions of pain levels measured at different times in the solution group (p<0.001). A statistically significant difference was found between the distributions of pain levels measured at different times in the gel group (p<0.001). In both groups, highest postoperative pain levels occurred in the first 6 hours. Pain levels of the gel group as 38,5% mild, 17.3% moderate, 5.8% severe and pain levels of the solution group were obtained as 46.2% mild, 26.9% moderate, 9.6% severe at the 6th hour. Conclusions: The use of the gel form of NaOCI during the chemomechanical preparation of the root canals showed similar postoperative pain when compared to the solution form. © 2021, Faculdade De Odontologia De Bauru. All rights reserved.
Effectiveness of Xp-Endo Finisher, Endoactivator, and Pui Agitation in the Penetration of Intracanal Medicaments Into Dentinal Tubules: a Confocal Laser Scanning Microscope Analysis
(Tabriz University of Medical Sciences, 2024) Akkol, E.; Özlek, E.
Background. This investigation assessed the impact of irrigation activation systems on the depth of penetration of intracanal medicaments into dentinal tubules. Methods. Ninety-six mandibular premolar teeth were prepared using ProTaper Next up to size X3. The teeth were randomly divided into four groups based on the final irrigation activation systems (n = 24): group 1: EndoActivator, group 2: XP-Endo Finisher, group 3: Passive ultrasonic irrigation (PUI), and group 4: control. After the final irrigation, all the samples were divided into two subgroups (n = 12): subgroup A: calcium hydroxide (Ca(OH)2) and subgroup B: modified triple antibiotic paste (mTAP). Statistical analysis involved three-way analysis of variance (ANOVA). Results. EndoActivator, XP-Endo Finisher, and PUI activation methods significantly increased the penetration of intracanal medicaments compared to conventional needle irrigation (P < 0.05). The XP-Endo Finisher group exhibited the highest penetration percentage and maximum penetration depth, showing a statistically significant difference from the EndoActivator group (P < 0.001). No significant difference was observed between XP-Endo Finisher and PUI, nor between PUI and EndoActivator (P > 0.05). mTAP showed a higher percentage of dentinal tubule penetration than Ca(OH)2, although no significant difference was found in maximum penetration depth. The coronal region demonstrated the highest penetration percentage and depth, while the apical region showed the lowest. Conclusion. This study showed the effectiveness of XP-Endo Finisher in improving the penetration of intracanal medicaments into dentinal tubules. The findings emphasize the importance of selecting appropriate irrigation activation systems to improve treatment outcomes in endodontics. By demonstrating the effectiveness of advanced systems like XP-Endo Finisher, this research supports their integration into routine clinical practice for better endodontic success. © 2024 The Author(s).
Five-Year Follow-Up of a Delayed Reimplanted Avulsed Tooth: Case Report
(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Özlek, E.; Ak, B.; Akkol, E.
This case involves the reimplantation of an avulsed mandibular central tooth that occurred two hours after an accident. A nine-year old girl had visited nearest dental health care center complaining of an avulsed mandibular central tooth two hours after her bicycle accident. The avulsed tooth had been kept in milk in for those two hours. It was reimplanted and referred to a dentistry faculty with a composite splint. The patient presented to our clinic three days later. The non-hygienic composite splint was removed and gingivoplasty procedure was performed by a periodontologist. The new splint was applied using polythene fiber post. Clinically normal periodontal tissues were detected after two weeks, and endodontic treatment was begun. Root filling of the clinically asymptomatic tooth was performed after 30 days, and coronal restoration finished using composites. The tooth is still functional now after five years. The long-term prognosis for the replanted tooth is unclear. During this growth period, however, the height of the alveolar bone has been preserved and is aesthetically satisfying. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.