Browsing by Author "Akkoyun, M.B."

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Effects of Clitoria Ternatea on Renal Ischemia and Reperfusion Injury in Rats
(Universidad del Zulia, Facultad de Ciencias Veterinarias, 2025) Melek, Ş.; Uyar, A.; Akkoyun, H.T.; Altun, S.; Akkoyun, M.B.; Karagözoğlu, F.; Bakir, A.
Ischemia-reperfusion (I/R) injury refers to damage caused by the temporary interruption of blood flow into an organ/ tissue and the restoration of circulation. This injury, which affects many vital organs, is still an important clinical and surgical problem. This study aims to investigate the effect of antioxidant and anti-inflammatory effects of Clitoria ternatea on renal I/R injury in rats. Twenty-four male Wistar albino rats were clustered into 4 groups, 6 rats in each (Control, I/R group, Clitoria ternatea group, I/R group + Clitoria ternatea group). At the end of the experimental procedures, all groups were euthanised in accordance with ethical rules. Blood and tissue samples were taken and subsequent biochemical (MDA, SOD, CAT, GSH-Px, BUN, Na, K, creatine), histopathological and immunohistochemical analyses demonstrated that Clitoria ternatea effectively prevented I/R-induced renal injury in rats. Based on these findings, Clitoria ternatea may be considered a potential therapeutic agent for the prevenstion of I/R-induced kidney damage. © (2025), (Universidad del Zulia, Facultad de Ciencias Veterinarias). All rights reserved.
Protective Effect of Ferulago Angulata (Schlecht.) Boiss on N-Nitrosodimethylamine Induced Oxidative Stress in Rats
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Kızıltaş, H.; Ekin, S.; Akkoyun, M.B.; Oto, G.; Akbaş, E.
The aim of the present study was to investigate the effect of Ferulago angulata (Schlecht.) Boiss. (FASB) extract on mineral (Ca, K, Na) and trace element (Cu, Zn, Se, Co, Fe, Mn, Cr, Pb, Ni, Cd) levels were determined in rat heart tissue, which was oxidatively stressed with N-nitrosodimethylamine (NDMA). Experimental period was continued with Wistar-Albino rats (n:60) in 21 days. Rats were treated with NDMA (10 mg/kg) in first seven days. FASB plant extract was given to the rats each day of the study. The rats were divided into six groups of ten rats each. The mineral and trace element levels of heart tissue were analyzed by using ICP-OES. The results show that NDMA group was significantly lower results than control group with regarding to Zn, Co and Na levels (p<0.05, p<0.01 and p<0.05). On the other hand the NDMA group was also significantly lower results than the FASB (300 mg/kg) group regarding Zn and Co levels (p<0.05 and p<0.05), whereas the FASB (150 mg/kg) group had increased level of Na according to NDMA group (p<0.05). In conclusion, due to the positive effect on significantly alteration in Zn and Co level of heart tissue, it was suggested that the FASB (150, 3 00 mg/kg) can be used in preventing hearth damage. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.