Browsing by Author "Aksoy, Nurten"

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Evaluation of Oxidative Status in Patients With Hyperthyroidism
(Humana Press inc, 2011) Aslan, Mehmet; Cosar, Niyet; Celik, Hakim; Aksoy, Nurten; Dulger, Ahmet Cumhur; Begenik, Huseyin; Selek, Sahbettin
Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = -0.434, P = 0.002) and FT4 levels (rho = -0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = -0.245, P = 0.037; rho = -0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, P = 0.011), while no correlation with serum TAC levels and TOS levels (P > 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative-antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients.
Protective Effects of Melatonin on Oxidative-Antioxidative Balance and Cataract Formation in Rats
(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Kilic, Adil; Selek, Sahbettin; Erel, Oezcan; Aksoy, Nurten
We investigated the effects of melatonin on cataract formation in rats exposed to selenite. We concluded that the imbalance between oxidants and antioxidants plays an important role in cataract formation and melatonin decreases cataract incidence in rats by increasing antioxidant activity.
The Relationship Among Oxidative and Anti-Oxidative Parameters and Myeloperoxidase in Subjects With Obstructive Sleep Apnea Syndrome
(Daedalus Enterprises inc, 2016) Arisoy, Ahmet; Ekin, Selami; Sertogullarindan, Bunyamin; Gunbatar, Hulya; Sunnetcioglu, Aysel; Aksoy, Nurten; Yildiz, Hanifi
Obstructive sleep apnea (OSA) is a highly prevalent breathing disorder in sleep. It is characterized by intermittent hypoxia leading to hypoxemia, hypercapnia, sleep fragmentation, and increased respiratory efforts. We evaluated the relationship between OSA and myeloperoxidase activity, the oxidative stress index (OSI), total anti-oxidative capacity (TAC), and total oxidative capacity (TOC). METHODS: A total of 70 consecutive subjects (mean age +/- SD: 51.7 +/- 11.7 y) were diagnosed with OSA after a night polysomnography recording between January 2014 and June 2014 consecutively. The subjects in the OSA group were divided according to the severity of the disease into three subgroups, consisting of 11 mild, 17 moderate OSA, and 22 severe OSA subjects. Twenty subjects with simple snoring were considered as the control group. RESULTS: We included a total of 70 subjects: 50 with OSA (11 subjects 6.9% mild, 17 subjects 24.7% moderate, and 22 subjects 68.5% severe) and 20 subjects with simple snoring as control cases. The mean age of the mild OSA subjects was 44.5 +/- 11.7 y, moderate OSA subjects' mean age was 52.5 +/- 11.9 y, and severe OSA subjects' mean age was 52.1 +/- 10.1 y; 54.2% were male. There were statistically significant differences among the 4 groups' OSI, TAC, and TOC levels, but there was no statistically significant difference between the other values. The mean myeloperoxidase, TOC, OSI, and TAC levels were 55 +/- 12, 61.2 +/- 21.1, 3.04 +/- 1.04, and 2.03 +/- 0.4 in the mild OSA group; 58.7 +/- 17.2, 60 +/- 18.9, 3.05 +/- 1, and 2 +/- 0.33 in the moderate OSA group; 56.6 +/- 17.9, 52.1 +/- 17.9, 2.7 +/- 0.76, and 1.94 +/- 0.24 in the severe OSA group; and 49.8 +/- 12.5, 54.3 +/- 16.4, 3.08 +/- 0.88, and 1.78 +/- 0.26 in the control group, respectively. CONCLUSIONS: In our study, there were no differences in studied parameters between control and OSA groups. Furthermore, our low number of cases was a restrictive factor. Further studies should be undertaken to clarify this relation.
Serum Myeloperoxidase (Mpo) Activity, Oxidative and Antioxidative Parameters in Operating Room Personnel
(Pakistan Medical Assoc, 2016) Cegin, Muhammed Bilal; Aslan, Mehmet; Goktas, Ugur; Isik, Yasemin; Soyoral, Lokman; Aksoy, Nurten; Kati, Ismail
Objectives: To investigate the effects of occupational exposure to anaesthetic gases on myeloperoxidase activity, oxidative and antioxidative parameters in operating room personnel. Methods: The cross-sectional study was conducted at Yuzuncu Yil University, Van, Turkey, in May 2011, and comprised equal number of operating room and non-operating room personnel. Serum myeloperoxidase activity, sulfhydryl group levels, lipid hydroperoxide levels and catalase activity were determined. SPSS 11 was used for data analysis. Results: There were 64 subjects; 32(50%) each in the two groups. Myeloperoxidase activity and lipid hydroperoxide levels were significantly higher in operating room personnel than in the non-operating room personnel (p<0.001; p<0.001), while catalase activity and sulfhydryl group levels were significantly lower (p<0.009; p<0.003). Catalase activity negatively correlated with lipid hydroperoxide levels in operating room personnel (r=-0.293; p=0.018). Myeloperoxidase activity negatively correlated with sulfhydryl group levels in operating room personnel (r=-0.267; p=0.031). Conclusions: Operating roompersonnel exhibited higher oxidative stress, which may be due to the oxidative effect of anaesthetic gases.