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Browsing by Author "Akyüz, A."

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    The Effect of Hydroxychloroquine on Ventricular Repolarization Parameters Jtc and Jtpc Intervals in Patients With Covid-19
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Bilge, Ö.; Çap, M.; Işık, F.; Altindag, R.; Akyüz, A.; Inci, Ü.; Altıntaş, B.
    JT and JTp intervals are among the ventricular repolarization parameters and prolongation, just as the Q T interval is related to ventricular arrhythmias. This study aims to examine the effect of hydroxychloroquine on JTc and JTpc intervals in individuals hospitalized with COVID-19. We involved 130 COVID-19 patients divided into two groups as the hydroxychlor oquine treatment group and the control group, in this study. ECGs of the patients were recorded at admission and after a median of 48 hours following the initiation of hydroxychloroquine treatment. Then, QTc, JTc, and JTpc intervals were measured. Patients’ average age was 48 (37-66 IQR), and 53% of the individuals were female. The median basal JTpc interval was 215 ms(195-230 IQR), while JTpc-Day 3 was 220 ms(195-238 IQR). The median basal JTc interval was 320 ms(301-334 IQR), while JTc-Day 3 was 328 ms(306-343 IQR). JTpc and JTc interval in the hydroxychloroquine group have prolonged significantly (p<0.001), while there were no significant changes in the control group for both values (p>0.05). There was a significant prolongation in the multivariable linear regression analysis in JTc-Day 3 and JTpc-Day 3 after hydroxychloroquine treatment. (ß=-2.589, 95%CI, 2.384-17.894, p=0.011, ß=2.195, 95%CI, 759-14.752, p=0.030, respectively). In this study, we found significant prolongation in JTc and JTpc intervals i n the patients who take hydroxychloroquine treatment. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
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    Separation of Retinol Acetate, Vitamin a Palmitate, Α- and Γ- Tocopherol by Reverse-Phase High Performance Liquid Chromatography and Determination of These Vitamins in Van Lake Fish (Chalcalburnus Tarichi)
    (Scientific and Technical Research Council of Turkey, 1997) Testereci, H.; Yörük, I.H.; Akyüz, A.; Saǧmanligil, H.
    The resolution properties of several commercial columns for vitamin A and E standards by reverse phase chromatography methods have been examined. Hypersil MOS column with methanol-water (96:4) and acetonitrile-water (90:10) mobile phase, Shimadzu-ODS column with methanol-water (96:4) mobile phase have acceptable resoluion in separation of vitamin A esters. Shimadzu-ODS column/96 % methanol and Shimadzu-C8/90% acetonitrile have the acceptable resolution ratio for vitamin E isomers. Methanol extracts of heart muscle and gill in Van Lake fish (Chalcalburnus tarichi) have been examined for vitamin A and E by high performance liquid chromatography. Avarage retinol acetate, vitamin A palmitate, alpha tocopherol, gamma tocopherol in heart muscle of Van Lake fish, have been found as 162±23 ng/g, 18±2.2 ng/g, 8.5±1.0 μg/g, 505.7±94 ng/g, respectively. The vitamin levels in gills have been determined as retinol acetate 231.5±38 ng/g, vitamin A palmitate 23.8±3.5 ng/g, alpha tocopherol 12.4±0.77 μg/g, gamma tocopherol 350.1±97 ng/g. A significant differences have been found among the retinol acetate-vitamin A patmitate and alpha-gamma tocopherol values in heart muscles and gills (P<0.05). A negative correlation for retinol acetate between heart muscle and gill (r:-.86), vitamin A palmitate between heart muscle and gill (r:-.73) and between retinol acetate-alpla tocopherol in heart muscles (r:-.71) have been observed. A positiv correlation between retinol acetate and alpha tocopherol in gills (r:+.52) has been found. No correlation has seen between heart muscles and gills for gamma tocopherol values.