Browsing by Author "Akyol, V."

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Anatomical and Stereological Examination of Infected Lung Area Volumes in Ct Images of Covid-19 Positive Patients by Age and Gender
(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Koyun, N.; Akyol, V.; Elasan, S.; Göya, C.; Gizli, G.
SARS-CoV-2 (COVID-19), a previously unidentified type of coronavirus in humans, causes respiratory tract infection. The infection is transmitted by droplets and leads to several serious diseases characterized by acute respiratory distress syndrome (ARDS). We aimed to examine the changes in the volumes of lung regions infected with COVID-19, a new and highly pathogenic strain, according to age and gender. After obtaining ethical permission, 6700 patients who applied with positive COVID-19 test were selected between 01/03/2020 and 01/03/2021. Patients with asthma, bronchiectasis, obstructive pulmonary disease, pleurisy, allergic lung disease, lung tumor, and smokers were excluded from the study. After the excluded patients, computed tomography images of a total of 407 COVID-19-positive patients, 188 women, and 219 men, were obtained retrospectively. From the images taken, 2 to 10-decade groups of male and female patients between the ages of 10 and 100 were formed for the study. Images were skipped at certain intervals from the lung CT images for each patient in the groups. By applying stereological methods to the images, the total volume of the lung and the volumes of the infected lung regions were calculated. In the analysis of the infected COVID-19 lung volume/total lung volume (%) ratio by gender and decades, there was a statistically significant difference according to gender in the 2nd, 6th, and 9th decades [(p=0.002), (p=0.001) and (p=0.032)] was observed. In the comparison of the infected COVID-19 lung volume/total lung volume ratio by decades, a statistically significant difference was observed in both genders (p=0.001). Further studies and medical research are needed to better understand age-and sex-specific differences for effective intervention. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Investigation of the Effects of Diclofenac Sodium in Rat Ovary on the Number of Preantral Follicles by Stereological Methods in Prenatal Period
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Çölçimen, N.; Rağbetli, M.Ç.; Kara, M.; Arıhan, O.; Akyol, V.
For healthy future generations pregnancy is a period in which maximum amount of attention should be given. In this period, choice, duration and dosage of medication as well as the changing physiology of the mother should be taken into account. Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs that have analgesic, anti-pyretic and antiinflammatory effects. This group of drugs can be used in the treatment of the ongoing rheumatic diseases or which occur during the pregnancy period and the complications that occur due to pregnancy. We aimed to show how it affects the number of ovarium preantral follicles of newborn fetus on rats by using Diclofenac Sodium which belongs to this drug family group. Diclofenac Sodium (1 mg/ kg, IM) was injected for 15 days from the 5th day of pregnancy to pregnant rats in Diclofenac Sodium group and saline (1 ml/ kg, IM) was injected to the pregnant rats of the sham group at the same time period. In the 4th week after birth, ovarian tissue preparates of rat pups were stained with hematoxylin-eosin and ovarian total tissue volumes and preantral follicle counts were evaluated under light microscope. There was no statistically significant difference between groups for ovarium total tissue volumes and preantral follicle numbers (p>0.05). Lowest value of follicular intensity was observed in Diclofenac sodium group among study groups however no statistically important difference was found (p>0.05). Results obtained in our study may be related with administration of drug in not a high dosage (1mg/kg). Further studies may be performed with higher doses. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Long-Term Effect of Deslorelin Implant on Ovarian Pre-Antral Follicles and Uterine Histology in Female Rats
(Wiley, 2013) Cetin, Y.; Alkis, I.; Sendag, S.; Ragbetli, M.; Akyol, V.; Ucar, O.; Wehrend, A.
Contents The objective of the present study was to investigate the inhibitory effects of long-term deslorelin implant administration on the ovarian and uterine structures of female rats. A total of 16 non-pregnant female rats were randomly assigned to two groups, each consisting of eight animals. Animals in the implant group (DESL) received subcutaneously (s.c.) a single deslorelin implant (4.7mg), an analogue of GnRH, while no treatment was applied to the control group (CON). A single adult male rat was introduced into the cages of both the DESL and CON females after 6weeks of implant administration. After 1year of implant administration, all animals were killed and follicular structures and volumes of ovaries and uterus were examined using stereological methods. Stereological observations showed that the mean ovarian total volume of the DESL group (0.28 +/- 0.07cm3) was lower than that of the CON group (1.55 +/- 0.23cm3) (p<0.001). On the other hand, the total number of pre-antral follicles in the ovaries of DESL (555.32 +/- 151.47) females were significantly lower than the control group (1162.96 +/- 189.19) (p<0.001). In the DESL group, the mean volumes of epithelium, endometrium, myometrium and total volume of the uterus were significantly (p<0.001) lower than in the control groups. In conclusion, these findings indicate that the long-term deslorelin implant (i) interferes with the normal cyclicity of female rats and (ii) affects the pre-antral follicle population. Further studies will be required to determine the effects of long-term deslorelin treatment on the pre-antral follicle numbers and future fertility in other species.
Long-Term Effects of Deslorelin on Ovarian Preantral Follicle Number in Female Rats: Preliminary Stereological Observations
(Wiley-blackwell, 2011) Alkis, I.; Sendag, S.; Cetin, Y.; Akyol, V.; Ragbetli, C.; Wehrend, A.; Ragbetli, M.