Browsing by Author "Alay, M."

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The Association Between Exocrine Pancreatic Dysfunction and Insulin Resistance in an Insulin-Resistant Population in Turkey: a Cross-Sectional Study
(Wolters Kluwer Medknow Publications, 2023) Yildiz, S.; Sonmez, G. M.; Komuroglu, A. U.; Alay, M.
Background:In insulin resistance (IR), it is thought that pancreatic fat accumulation may decrease pancreatic volume, cause an impaired endocrine function, and simultaneously lead to an exocrine dysfunction before diabetes develops. Aim:The association between pancreatic exocrine function and insulin resistance (IR) was assessed in a population with insulin resistance. Method:This was a descriptive cross-sectional study that included 43 IR cases with no other comorbid diseases or pregnancy and 41 healthy controls. Fasting blood adiponectin, leptin, pancreatic amylase, lipase, and stool fecal elastase-1 (FE-1) were studied and compared in both groups. Results:The IR group consisted of 38 females (88.3%) and five males (11.6%), while the control group consisted of 31 females (75.6%) and ten males (24.3%). FE-1 levels were significantly lower in the IR group (P-value <0.01). Blood glucose, insulin, and HbA1c levels were significantly higher in the IR group than in the control (P-value of <0.01, <0.01, <0.01, respectively). Leptin levels were significantly higher in the IR group compared to the controls (P-value = 0.013). After dividing the whole group (n: 84) into two groups as FE-1 <200 & mu;g/g (n: 61) and FE-1 & GE;200 & mu;g/g (n: 23), logistic regression analysis was performed; the significant predictor of low FE-1 was HOMA-IR (ODD ratio: 4.27, P-value <0.01, 95% confidence interval for ODD ratio: 1.95-9.30). Conclusion:This study showed that IR is associated with pancreatic exocrine dysfunction.
Detection of Diseases, in Renal Donor Patients, During the Posttransplant Period and Researching
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Alay, M.; Kara, T.
Kidney donors are followed up periodically for health problems such as chronic renal failure(CRF), hypertension(HT), diabetes mellitus(DM) that may develop after transplantation. The aim of this study was to determine the disease and to investigate the risk factors in renal donors followed in the outpatient clinic of the nephrology. In this study, 40 patients with renal donors aged between 18-75 years who were admitted to the nephrology clinic were included. From all donors; anamnesis was taken to determine if there was any disease after kidney transplantation and physical examinations were performed.Donors have previously looked at; 24-hour urinary glomerular filtration rate(GFR) and proteinuria measurement, creatinine, alanine aminotransferase(ALT), fasting glucose, hemoglobin A1c(HgbA1c) values were recorded. According to the physical examination and laboratory results of the donors, systemic disease after transplantation and risk factors were evaluated. Of the 40 donors included in the study, 29(72%) were female and 11(18%) were male. In the post-transplant background; 3(7.5%) had DM, 6(15%) had HT and 1(2.5%) had both DM and HT. The mean GFR was 81.6±21.3 ml/min. The viral markers of the donors were negative for anti-HCV, anti-HIV and HbsAg. As a result of the study, the incidence of diseases such as DM, HT, CRF in the follow-up of kidney donors admitted to our clinic was found to be the same as in the community. The fact that the incidence of donor diseases after transplantation is the same as the incidence in the community leads to a better option in the treatment of end-stage renal disease. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Effects of Blood Glucose Regulation and Treatment Regime on Mean Platelet Volume in Type 2 Diabetic Patients
(Wolters Kluwer Medknow Publications, 2021) Alay, M.; Atmaca, M.; Ucler, R.; Aslan, M.; Seven, I; Dirik, Y.; Sonmez, M. G.
Background: Mean platelet volume (MPV) is associated with cardiovascular morbidity and mortality in type 2 diabetic patients. However, the effects of blood glucose regulation and treatment regime on MPV has not been adequately studied in type 2 diabetic patients. Aims: We studied the effects of blood glucose regulation and treatment regimen on mean platelet volume in Type 2 diabetic patients. Subjects and Methods: A total of 232 diabetic patients who were admitted to the hospital in short intervals of 3 months in the last 2 years were included in the study. When the second admission HbA(1c) was greater than the first admission HbA(1c), they were classified as being in the deteriorated blood glucose regulation group, otherwise they were classified in the improved blood glucose regulation group. Also, the deteriorated and improved blood glucose regulation groups were classified based on therapy modalities as the sulfonylurea + metformin group and the insulin + metformin group. Paired t-test was used for comparison of the groups. Results: Of the 232 patients, 98 (42.2%) were male and 134 (57.8%) were female. There were 126 (55.2%) patients using sulfonylurea + metformin, while 106 (44.8%) patients were using insulin + metformin. MPV levels were significantly increased in patients with deteriorating glucose regulation (p = 0.003). This increase in MPV was only seen in the oral hypoglycemic treatment group (p = 0.003). Conclusions: Our results suggested a close relationship between poor glycemic control and increased platelet activity in type 2 diabetic patients with oral antidiabetic therapy when compared to the insulin and metformin therapy modality.
Evaluation of Blood Neutrophil To Lymphocyte and Platelet To Lymphocyte Ratios According To Plasma Glucose Status and Serum Insulin-Like Growth Factor 1 Levels in Patients With Acromegaly
(Sage Publications Ltd, 2016) Ucler, R.; Aslan, M.; Atmaca, M.; Alay, M.; Ademoglu, E. N.; Gulsen, I.
Introduction: Cardiovascular, respiratory, and cerebrovascular diseases and malignancies are responsible for morbidity and mortality in acromegaly. Also these diseases are associated with chronic inflammation. The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are currently gaining interest as new markers of inflammation. Moreover, increased morbidity and mortality are positively correlated with the presence of diabetes and levels of insulin-like growth factor 1 (IGF-1) in acromegaly. The objective of the present study was to investigate the relationship between these markers and acromegaly according to plasma glucose status and serum IGF-1 levels. Materials and Methods: We retrospectively analyzed data from 61 acromegaly patients who were in a newly diagnosed period (35 male, 26 female; mean age 38.13 +/- 13.98). Patients with normal plasma glucose (n = 27), impaired fasting glucose (n = 18), and diabetes mellitus (n = 16) were categorized into three different groups. NLR and PLR were compared between the study groups and were evaluated according to IGF-1 levels. Results: There were no statistically significant differences inNLR and PLR measurements among the study groups (p > 0.05). However, there were significant positive correlations between NLR and IGF-1 levels and between PLR and IGF-1 levels when all patients were evaluated (r = 0.334, p = 0.011 and r = 0.277, p = 0.035, respectively). Conclusions: This is the first report studying the relationship of NLR and PLR with glucose status and IGF-1 levels in acromegaly patients. Our study results suggest that subclinical inflammation may play a role in increased incidence of mortality and morbidity, which depends on uncontrolled IGF-1 levels in patients with acromegaly.
Evaluatıon of Neutrophıl-To Ratıo and Mean Platelet Volume in Patıents With Hyperthyroıdısm
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Alay, M.; Sönmez, G.M.; Yildiz, S.
Both Lymphocytes and platelets play an important role in the pathogenesis of Graves' disease (GD), a chronic inflammatory autoimmune disease. The mean platelet volume (MPV), which is considered as an indirect indicator of platelet function, may be increased as an inflammatory marker in GD. The aim of this study is to prove that the autoimmune, chronic inflammatory pathogenesis of GD can be demonstrated by evaluating the whole blood count parameters A total of 75 patients of which 41 were diagnosed as GD and 34 were diagnosed as TNG were included in the study. Complete blood count parameters were evaluated in both groups before treatment and after treatment when euthyroidism was achieved. In GD group, pretreatment MPV values were significantly higher than TNG group (p: 0.021). There was a statistically significant decrease in NLR in GD group compared to TNG group after treatment (p: 0,025). Although there was no statistically significant difference, lymphocyte count was higher in GD group compared to TNG group be fore treatment. The monocyte count was significantly higher in the GD group compared to the TNG group before treatment (p: 0.006). There was no correlation between MPV and free T3, free T4, TSH values before and after treatment in GD group. These results suggest that autoimmunity and inflammation in GD are reflected in whole blood count parameters and that MPV elevation in GD is related to autoimmunity rather than the metabolic effect of thyroid hormones. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Which Hemogram Parameter Is More Cautionary in Euthyroid Patients With Gestational Diabetes Mellitus
(Yuzuncu Yil Universitesi Tip Fakultesi, 2016) Yıldız, S.; Üçler, R.; Alay, M.; Ekici, E.B.
Gestational Diabetes Mellitus is the most diagnosed metabolic disease in pregnancy. The mother and fetus are affected both adversely for this disorder. Gestational Diabetes pathogenesis is associated with subchronic inflammation. The aim of this study was to compare the various hemogram parameters in euthyroid patients with Gestational Diabetes Mellitus and healthy pregnant controls and to determine which parameter is more cautionary for Gestational Diabetes Mellitus diagnosis. This study was conducted in the Endocrinology Department of Van Training and Research Regional Hospital and Obstetrics and Gynecology Department of Private Lokman Heki̇m Van Hospital. The 53 GDM patients and 35 healthy pregnant women, whose gestational age were higher than twenty four weeks and whose euthyroid, normotansive were included in the study. Statistically significant relationships between platelet count (PC), platelet distribution width (PDW), lymphocyte count (LC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red cell distribution width (RDW) and GDM disease were found (p; 0.000, 0.000,0.000, 0.000, 0.000, 0.007 respectively). Platelet distribution width had higher sensitivity and specificity than other parameters. Although platelet distribution width is a less known or an unconsidered parameter in complete blood count, it gives more precise information than other hemogram parameteres. It may be convenient to screen the gestational diabetes as an adjunct to oral glucose tolerance test. © 2017 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.