Browsing by Author "Alici, Suleyman"

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Analysis of Factors Associated With Survival in Advanced Stage Gastric Adenocarcinoma
(Kare Publ, 2005) Alici, Suleyman; Kaya, Serap; Izmirli, Mustafa; Tuncer, Ilyas; Dogan, Ekrem; Ozbek, Hanefi; Sayarlioglu, Hayriye
In this study, 138 patients with high grade gastric adenocarcinoma who were admitted to Yuzuncu Yil University, Medical School, Department of Medical Oncology between September 1999 and April 2002 were retrospectively evaluated in terms of the effects of clinicopathological parameters and treatment approaches on survival by single and multiple variable analyses. Patients histopathologically diagnosed as gastric adenocarcinomas with stage IV M0 (without distant organ metastasis) or stage IV M1 (with distant organ metastasis) were included in the study. Mean age of the patients was 61.1 (34-84), 64.6% male and 35.5% female. The ratio of patients with a performance score of 2-3 was 55%. The BMI was below 20 in 53.6% of the patients. According to histological grading, 41.9% of patients had indifferentiated adenocarcinoma, mucinous cell adenocarcinoma or signet ring cell adenocarcinoma. 84% of patients were clinically at stage IV M1. The percentage of patients with tumor localized upper 1/3 of stomach was 60.8%. While 19.6% of patients had received surgical treatment, 47% of the patients had received chemotherapy as adjuvant or paliative purposes. The percentage of the patients who responded to the therapy (complete response + partial response + stable response) was 39% and the percentage of patients who had progression was 7.2%. Overall median survival time was 3.1 months and three years survival rate was 8%. At single variable analysis, BMI, clinical stage, surgery, type of surgery and serum level of albumin were significant prognostic factors related to overall median survival time. Gender, clinical stage, surgery, type of surgery, hemoglobine concentration and serum level of albumin were found to be significant prognostic factors related to survival without progression (p<0.05). The factors found to be significant related to overall survival rate in single variable analysis were reevaluated in multiple variable analysis. No surgical treatment, paliative surgery (compared to radical surgery), BMI below 20 were found to be the statistically significant poor prognostic factors related to survival. The factors found to be significant related to survival without progression in single variable analysis were evaluated in multiple variable analysis and no surgical treatment (compared to surgery), male gender (compared to female) were found to be statistically significant poor prognostic parameters. In terms of both overall survival and survival without progression, whether performing surgery or not was statistically most significant independent prognostic factor. In conclusion, no surgical treatment, paliative surgery instead of radical surgery, and BMI below 20 on first admission were determined as poor prognostic factors related to survival in patients with high grade gastric adenocarcinoma.
Analysis of Survival Factors in Patients With Advanced-Stage Gastric Adenocarcinoma
(int Scientific information, inc, 2006) Alici, Suleyman; Kaya, Serap; Izmirli, Mustafa; Tuncer, Ilyas; Dogan, Ekrem; Ozbek, Hanefi; Sayariloglu, Hayriye
Background: Prognosis in patients with gastric cancer is determined by the tumor itself, as well as certain patient-related factors. Material/Methods: In this study, 138 patients with high-grade gastric adenocarcinoma who were admitted to our hospital between September 1999 and April 2002 were retrospectively evaluated in terms of the effects of clinicopathological parameters and treatment approaches on survival by single and multiple variable analyses. Patients histopathologically diagnosed as having gastric adenocarcinomas with stage IV M-0 (without distant organ metastasis) or stage IV M-1 (with distant organ metastasis) were included in the study. Results: Overall median survival time was 3.1 months and three-year survival rate was 8%. With single variable analysis, body mass index (BMI), clinical stage, surgery, type of surgery, and serum level of albumin were significant prognostic factors related to overall median survival time. Gender, clinical stage, surgery, type of surgery, hemoglobin concentration, and serum level of albumin were found to be significant prognostic factors related to survival without progression (p < 0.05). No surgical treatment, palliative surgery (compared with radical surgery), and BMI below 20 were found to be the statistically significant poor prognostic factors related to survival in multiple variable analysis. In terms of both overall survival and survival without progression, performing surgery or not was statistically the most significant independent prognostic factor. Conclusions: No surgical treatment, palliative surgery instead of radical surgery, and BMI below 20 on first admission were determined as poor prognostic factors related to survival in patients with high-grade gastric adenocarcinoma.
Epidemiologic Evaluation of the Patients Admitted To Department of Medical Oncology, Yuzuncu Yil University, Medical Faculy
(Kare Publ, 2006) Alici, Suleyman; Izmirli, Mustafa; Dogan, Ekrem
OBJECTIVES In this study the aim was to evaluate the cancer incidence, tumour and patient characteristics in Lake Van region by using the registry data of Medical Oncology Department. METHODS Patients (861 males (54.4%); 723 females (45.6%) [man to female ratio was 1.19]; mean age 53; range 14 to 90 years) admitted to Department of Medical Oncology, Ytiztincti Yil University and having diagnosed as cancer (n=1584) between lth January 2001 and 31th December 2004, were evaluated retrospectively. The disease was seen most frequently (23.8%) in 51 to 60 years old age group, also 70.5% of all cases were within the age range of 41-70. The 43.6% of the cases were having local-regional and 56.4% were having metastasized disease. RESULTS When all patients considered the most frequent five types were as follows; gastric cancer 26.5%, esophagus cancer 15.8%, breast cancer 9.5%, colorectal cancer 7.6% and lung cancer 6.4%. When evaluated for gender the most frequent five cancers for women were breast (19.8%), stomach (19.6%), esophagus (19.2%), colorectal (7.3%) and over (5.5%), for men stomach (32%), esophagus (13%), lung (9.3%), colorectal (7.9%), and lymphoma (5.4%). When considered for the systems the most frequent cancer localizations were gastrointestinal system (56.6%), breast (9.5%), lung (6.4), lymphoma (5%) and urologic (4.8% ). CONCLUSION Upper gastrointestinal system tumors are more frequent in Lake Van region for both man and women. Etio-pathologic studies are needed for this difference.
Prognostic Factors and Cox-2 Expression in Advanced Stage Esophageal Squamous Cell Carcinoma
(Springer, 2006) Alici, Suleyman; Ugras, Serdar; Bayram, Irfan; Izmirli, Mustafa
Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including squamous cell carcinomas of the esophagus, but its clinicopathologic role in esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to analyze expression of COX-2 in ESCC and to correlate this expression with clinicopathologic parameters and survival. From 1999 to 2003, endoscopic tissue samples from 110 patients with ESCC were collected for analysis. COX-2 expression was examined through immunohistochemical staining. Clinicopathologic data were analyzed to verify significance. COX-2 expression was detected in 50 of 110 ESCC specimens (45%). COX-2 expression was negative to weak in 73% (COX-2 low) and moderate to strong in 27% (COX-2 high) of tumors. Statistical differences between COX-2 high and COX-2 low were found according to status of the stage (stage IVM1a/IVM1b) (P=.001): cancer antigen (CA) 19-9 (normal/high) (P=.011), CA 12-5 (normal/high) (P=.011), and CA 15-3 (normal/high) (P=.035). Survival was significantly reduced among patients with high COX-2 expression (median overall survival, 3 mo) when compared with the COX-2 low group (median overall survival, 6 mo) (P=.0001). In the univariate analysis, age, body mass index, stage, COX-2, lactate dehydrogenase, CA 12-5, and CA 15-3 were significant factors for survival. With the use of COX regression analysis, only stage (P=.000), COX-2 (P=.000), lactate dehydrogenase (P=.023), and CA 15-3 (P=.002) were independent prognostic factors. Results showed that in patients with ESCC, COX-2 overexpression was significantly correlated with visceral metastases (IVM1b). COX-2 overexpression is an unfavorable prognostic factor in ESCC.
Rheumatoid Arthritis and Pulmonary Carcinoid Tumor
(Modestum Ltd, 2005) Sayarlioglu, Mehmet; Izmirli, Mustafa; Uzun, Kursat; Alici, Suleyman; Erkoc, Reha
A 40-yearold woman was admitted with a history of elbow, wrist, knee pain and prolonged morning stiffness. Rheumatoid arthritis (RA) diagnosed before five years, had been treated with non-steroidal anti-inflammatory agents and low dose corticosteroid. On hospital admission, routine chest x-ray showed a 4x4 cm solitary mass in the right pulmonary. A diagnostic thoracotomy was performed. The histological examination showed a typical carcinoid tumor. This is the third carcinoid tumor case reported to be associated with RA.