Browsing by Author "Alizade, A."

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Global Trends in Alzheimer's Disease Treatment: a Bibliometric Analysis
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Alizade, A.; Temelli Göçeroğlu, R.
Alzheimer's disease is a neurodegenerative disease characterized by cognitive and functional deficiencies, such as behavioral changes. As the disease progresses, neurons in the brain are damaged or disappeared. Nowadays, Alzheimer's disease and other common dementia do not have a treatment. None of the pharmacological treatments are currently effective in slowing down Alzheimer's dementia or stopping neuron damage. This paper offers a bibliometric analysis of the literature on treatments for Alzheimer's Disease indexed in the Web of Science database spanning 44 years. The study employed the VOSviewer visualization methodology to conduct the bibliometric analysis. The dataset consisted of articles retrieved from the Web of Science database, covering data on countries, institutions, journals, co-authorship, and international collaborations. In total, 56,530 publications were collected from the Web of Science database. The United States of America (USA) emerged as the leading country in terms of published articles, accounting for 20,389 (36.068%) of the total, followed by China with 5,434 (9.613%) publications, and England with 4,594 (8.127%). Excluding the top three countries mentioned above, publications originated from 168 countries worldwide. Since the 2000s, there has been a notable increase in publication numbers. Leading affiliations include the University of California System (USA) (2.959%), Harvard University (USA) (2.117%), and the University of London (England) (1.951%). The majority of these prominent affiliations are situated in the USA. In summary, this study represents the current bibliometric assessment of treatments for Alzheimer’s Disease. The results of this research will provide foresight to advanced Alzheimer's Disease Treatment research and provide different perspectives on its development. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Metformin Induces Mitochondria-Mediated and Endoplasmic Reticulum Stress-Mediated Apoptosis and Inhibits Angiogenesis-Related Gene Expression in Breast Cancer Cells Via Targeting Vegf-a/Vegfr2
(2025) Alizade, A.; Evyapan, G.; Celik, I.S.; Ozdem, B.
AIM: To investigate the apoptotic and anti-angiogenic effects of metformin in human MCF7 breast cancer cells. METHODS: The effect of metformin on cell viability was assessed by MTS and crystal violet assays, and its effect on cell migration was evaluated by the wound healing assay. The gene expression and protein levels of angiogenesis- and apoptosis-related genes were determined by real-time polymerase chain reaction, Western blot, and flow cytometry. RESULTS: Metformin reduced the viability and migration of breast cancer cells compared with the control group. Furthermore, metformin (10 μM) increased the apoptosis-related gene and protein expression of caspase-3, Bax, AIF, CHOP and GRP78 48 hours after treatment compared with the control group. In contrast, it significantly decreased Bcl-2 and Wee1 gene and protein expression and suppressed angiogenesis-related genes VEGFA, VEGFR2, and NRP1. CONCLUSIONS: Our results suggest that metformin treatment activates apoptosis pathways and inactivates the angiogenesis pathway. Although this study was conducted in vitro and did not directly evaluate blood vessel formation, the observed downregulation of angiogenesis-related genes suggests potential anti-angiogenic activity of metformin at the gene expression level.