Browsing by Author "Alkan, Sevil"

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Bibliometric Analysis of Neurocysticercosis Case Reports and Evaluation of Presented Cases
(Academic Press Ltd- Elsevier Science Ltd, 2025) Gurbuz, Esra; Aydemir, Selahattin; Barlik, Fethi; Saygin, Murat; Yildiz, Rahmi; Alkan, Sevil; Ekici, Abdurrahman
Neurocysticercosis (NCC) has been classified as a neglected tropical disease by the World Health Organization (WHO), with the condition being regarded as the most significant parasitic disease affecting the nervous system. Hence, the aim of this study was to conduct a review of previously published case reports on this topic in order to ascertain whether there is an increasing trend of NCC worldwide and evaluate the cases that have been presented. After a comprehensive search of the Web of Science Core Collection using the keywords "neurocysticercosis" and "case reports", studies were selected by applying inclusion criteria. Important data attributes that were extracted in plain text format included the document titles, publication years, journal names, author(s) name(s), keywords, institutions, and countries. In addition, to evaluate the cases, the age and gender of the patients, complaints on admission, localization of the cyst, and treatment procedure used were recorded in an Excel file. The bibliometric analysis was conducted using Biblioshiny. Additionally, GraphPad and Excel were employed for the creation of graphical representations. The dataset analyzed included 297 documents, 162 from various sources, with an average age of 12.2 years and 6.3 citations per document. The number of case reports tended to increase over the years. India and the USA were the leading contributors to NCC case reports, with 78 (26.3 %) and 64 (21.5 %), respectively. This was followed by Brazil, France, and Spain with 31 (10.4 %), 14 (4.7 %) and 13 (4.4 %) case reports, respectively. Moreover 55.5 % of the patients in the cases presented in the articles were male and 12.9 % were in the 21-25 age group. In regard to the cysts, 81.2 % were located in the brain and 15.1 % were in the spine. The most common complaints were headache and seizures in brain localized NCC cases and back pain and numbness or weakness in extremities in spine localized NCC cases. Albendazole was used in 174 (54.5 %) cases, praziquantel in 22 (6.9 %) cases, and ivermectin in five (1.6 %) cases. In conclusion, NCC continues to be an increasingly serious public health problem in India as well as developed countries such as the USA and European countries. NCC can be seen in all age groups, males are more susceptible than females, cysts are more localized in the ventricular system, and albendazole and/or paraziquentel are used in treatment. In addition, more comprehensive studies on the use of ivermectin in the treatment of NCC should be conducted, as success was achieved in cases where ivermectin was used in treatment.
The Clinical Features, Treatment and Prognosis of Neutropenic Fever and Coronavirus Disease 2019 Results of the Multicentre Teos Study
(Nature Portfolio, 2024) Elik, Dilsah Baskol; Kaya, Safak; Alkan, Sevil; Demirdal, Tuna; Sener, Alper; Kaya, Selcuk; Sipahi, Oguz Resat
This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 +/- 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639-16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137-20.172), the need for mechanical ventilation (p < 0.001, OR 62.042, 95% CI 9.528-404.011); (iii) need for mechanical ventilation: failure to recover from neutropenia (p < 0.001, OR 17.869, 95% CI 3.592-88.907), receiving tocilizumab therapy (p = 0.028, OR 32.227, 95% CI 1.469-707.053), septic shock (p = 0.001, OR 15.4 96% CI 3.164-75.897), and the need for ICU (p < 0.001, OR 91.818, 95% CI 15.360-548.873), (iv) OMM: [mechanical ventilation (p = 0.001, OR 19.041, 95% CI 3.229-112.286) and septic shock (p = 0.010, OR 5.589,95% CI 1.509-20.700)]. Although it includes a relatively limited number of patients, our findings suggest that COVID-19 and FEN are associated with significant mortality and morbidity.
Erişkin Kist Hidatik Vakalarının Retrospektif Değerlendirilmesi
(2024) Çelik, Mehmet; Baran, Ali Irfan; Altındağ, Deniz; Arslan, Yusuf; Tarcan, Tayyar; Sunnetcioglu, Mahmut; Alkan, Sevil
Amaç: Bu çalışmanın amacı kist hidatik nedeniyle takip edilen erişkin hastaların özelliklerini değerlendirmekti. Yöntem: Çalışmaya Ocak 2015-Eylül 2021 tarihleri arasında kist hidatik tanısı konan 18 yaş üstünde hastalar dahil edildi. Hastalara ait klinik, laboratuvar, radyolojik özellikler retrospektif olarak değerlendirildi. Bulgular: Çalışmaya 66 hasta dahil edildi. Hastaların %59,1’i kadın cinsiyette olup, yaş ortalaması 40.9±15.60 yıldı. Hastaların en sık tarifledikleri başvuru semptomu karın ağrısıydı (%42,4). En sık tutulum yeri sırasıyla karaciğer (%78,8) ve akciğerdi (%18,2). Hastaların büyük çoğunluğunda soliter kist (%84,8) vardı. Laboratuvar tetkiklerinde en sık saptanan bulgu total IgE yüksekliğiydi (%74,1). İndirekt hemaglütinasyon (IHA) testi, test edilen hastaların % 77,4’ünde pozitif olarak saptandı. Sonuç: Çalışmamızda kist hidatiğin en sık karaciğerde görüldüğü, sıklıkla tek organ tutulumu şeklinde olduğu, laboratuvar tanısında total IgE yüksekliğinin kist hidatik hastalığınını kesin tanısını koydurmasa da tanıya yardımcı olabileceği sonucuna varıldı.
Global Trends on Blastocystis Spp. Research: a Scientometric Study
(Egyptian Parasitologists United Soc - Epu, 2023) Bilden, Alican; Gurbuz, Esra; Aydemir, Selahattin; Unlu, Ahmet H.; Ekici, Abdurrahman; Alkan, Sevil; Cicek, Muttalip
Background: For many years, the classification and pathogenicity of Blastocystis was a subject of debate. The study rational is built on two hypotheses; whether this uncertainty affects the research on Blastocystis spp., and whether regional differences have an impact on diseases prevalence.Objective: The aim of this study is to guide researchers interested in blasticystosis by presenting a bibliometric review of the existing literature on blastocystosis.Material and Methods: The VOSviewer visualization methodology was used. Institutions, nations, international collaborations, journals, articles, authors, keywords, co-authors, co-citations, and citation rates from the WoS database formed the study data. A total of 1192 documents were found in the WoS database, of which 906 original articles were analyzed.Results: The articles were cited 24,065 times in total and the mean Hirsch (H) index was 74. The countries with the highest number of articles were as follows: USA (n = 93; 10.26%), Singapore (n = 79; 8.72%), China (n = 76; 8.39%), and Malaysia (n: 74; 8.17%). During the period from 2000-2013, there were a limited number of articles, while since 2014 there was a minimum of 34 publications per year. The highest number of articles was published in 2021 (n = 87) and the highest number of citations (n=3,485) was in 2021. The leading affiliation according to the number of published articles was the National University of Singapore (8.72%), University Malaya (6.62%), and Nara Women's University (4.64%). The USA, Singapore, China and Malaysia have led scientific production on Blastocystis spp.Conclusion: Due to development of recent molecular technology, the interest in Blastocystis spp. increased as recorded by ample publicatios and cited references. Development of interdisciplinary scientific research networks to include the most productive countries is crucial for Blastocystis related studies.
Molecular Characterization of Giardia Intestinalis and Cryptosporidium Spp. Detected in Humans in Ağrı, Türkiye
(Iranian Scientific Society Medical Entomology, 2024) Aydemir, Selahattin; Barlik, Fethi; Ekici, Abdurrahman; Barlik, Dilara Hande; Alkan, Sevil; Gurbuz, Esra; Yilmaz, Hasan
Background: We aimed to determine the prevalence of Giardia intestinalis and Cryptosporidium spp. in patients who admitted hospital with diarrhea and to gain information about the transmission of these parasites in Agri, Turkiye. Methods: This study included 184 patients who applied to Agri-Diyadin State Hospital, Turkiye in 2022. The immunochromatographic card test was used for detection of the G. intestinalis and Cryptosporidium spp. Nested PCR-RFLP analysis of the COWP gene and sequence analysis of the gp60 gene were used to genotype and subtype Cryptosporidium spp., whereas Nested PCR and sequence analyses of beta-giardin gene were used genotype G. intestinalis. Results: Of the 184 stool specimens examined, 12 (14.29%) and 7 (3.80%) were positive for G. intestinalis and Cryptosporidium spp., respectively. The Cryptosporidium species were identified as C. parvum belonging to the IId subtype family. The G. intestinalis were identified assemblages A. Conclusion: Assemblage A, which is associated with diarrhea, is responsible for giardiasis and C. parvum IId subtype, often found in sheep, goats and cattle, is responsible for cryptosporidiosis in Agri, Turkiye.
Trends in Naegleria Fowleri Global Research: a Bibliometric Analysis Study
(Elsevier, 2022) Ekici, Abdurrahman; Alkan, Sevil; Aydemir, Selahattin; Gurbuz, Esra; Unlu, Ahmet Hakan
Naegleria fowleri is one of the most dangerous protozoan agents. This article describes a bibliometric review of the literature on N. fowleri research indexed in WoS during a 51-year period. The VOSviewer visualization meth-odology was used to conduct a bibliometric study. The data included articles from the Web of Science database, nations, institutions, journals, keywords, co-authorship, co-citations, international collaborations, and citation rates. A total of 1106 articles were retrieved from the Web of Science database. The articles were cited 21,904 times in total (cited 12,138 times without self-citations). The average citation per article was 19.82. The Hirsch index was 63. The leading country according to the number of published articles was the United States of America (USA) (n = 447; 40.416%), followed by Mexico (n = 80; 7.233%), and Australia (n = 63; 5.696%). Other than these top three countries, the publications were from 74 countries globally. Especially after the 2000s, both the number of citations and the number of publications exhibited an increasing trend. The Virginia Common-wealth University (USA) (9.584%), Centers for Disease Control Prevention (USA) (8.770%), and Instituto Poli-tecnico Nacional Mexico (4.069%) were the leading affiliations. Most of the leading affiliations were from the USA and Mexico. In conclusion, a bibliometric evaluation of N. fowleri was performed for the first time. Authors affiliated with institutions in the USA and Mexico have led scientific production on PAM. Efforts should be made to help developing countries with the highest prevalence of N. fowleri to develop scientific research networks with the USA and/or Mexico in order to increase research with interdisciplinary teams.