Browsing by Author "Alkis, I."

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Analysis of Patients With Cytology Negative and Hpv 16/18 Positive on Cervical Cancer Screening Program: Experience From a Single Center in Eastern Region of Turkey
(Lippincott Williams & Wilkins, 2017) Karaman, E.; Alkis, I.; Kolusari, A.
Effect of Estrogen/Drospirenon Combinations and Tibolone on Biochemical Parameters and the Endometrium in Ovariectomized Rats
(Wiley-blackwell, 2010) Alkis, I.; Sendag, S.; Oto, G.; Yildirim, S.; Wehrend, A.
Effect of Estrogen/Drospirenon Combinations and Tibolone on Serum Leptin Levels in Ovariectomized Rats
(Wiley-blackwell, 2011) Alkis, I.; Sendag, S.; Tasal, I.; Cetin, Y.; Wehrend, A.
Effects of High-Rate Frequency Modulation Treatment on Malondialdehyde in Diabetic Polyneuropathy
(Asian Journal of Chemistry, 2010) Kavak, S.; Dulger, H.; Tulgar, M.; Alkis, I.
This study is planned to investigate the effects of transcutaneous electrical nerve stimulation (TENS) treatment on patients which have diabetic polyneuropathy. Fourteen diabetic polyneuropathy patients suffering ischemic pain were examined during the cure. Malondialdehyde (MDA) and glycemia levels were determined by collecting 5 mL blood samples from 14 patients 24 h before beginning the treatment. In case 50 Hz signals as high-rate frequency modulation (HRFM; continuous pulses changed from 90 Hz to 55 Hz over 90 msec, 1.3 times a second), were applied to patients as long as 20 d for 20 min a day. Transcutaneous electrical nerve stimulation (TENS) treatment increased significantly free oxygen radicals (p < 0.05). The levels of MDA before TENS were compared to the levels of MDA after TENS and the end of the following term of 20 days by paired sample test and a meaningful increase was seen significantly (p < 0.01). Besides, glycemia levels were decreased significantly before TENS-after TENS treatment (p/< 0.01) and not changed before TENS and the end of the following term of 20 d (p > 0.05.). Moreover, it was observed that MDA levels were decreased significantly between in the final of the treatment and the end of the following term of 20 d (p < 0.01). Glycemia levels were not changed significantly after TENS and the end of the following term of 20 d (p > 0.05). According to this results, it is observed that TENS treatment has been positive effect on poly neuropathy.
Investigation of Downregulation Effect of Deslorelin Implant in Female Rats: a Preliminary Report
(Wiley-blackwell, 2010) Sendag, S.; Alkis, I.; Eski, F.; Wehrend, A.
Long Term Suppression of Estrus and Prevention of Pregnancy by Deslorelin Implant in Rats: a Preliminary Report
(Wiley-blackwell, 2011) Alkis, I.; Cetin, Y.; Sendag, S.; Wehrend, A.
Long-Term Effect of Deslorelin Implant on Ovarian Pre-Antral Follicles and Uterine Histology in Female Rats
(Wiley, 2013) Cetin, Y.; Alkis, I.; Sendag, S.; Ragbetli, M.; Akyol, V.; Ucar, O.; Wehrend, A.
Contents The objective of the present study was to investigate the inhibitory effects of long-term deslorelin implant administration on the ovarian and uterine structures of female rats. A total of 16 non-pregnant female rats were randomly assigned to two groups, each consisting of eight animals. Animals in the implant group (DESL) received subcutaneously (s.c.) a single deslorelin implant (4.7mg), an analogue of GnRH, while no treatment was applied to the control group (CON). A single adult male rat was introduced into the cages of both the DESL and CON females after 6weeks of implant administration. After 1year of implant administration, all animals were killed and follicular structures and volumes of ovaries and uterus were examined using stereological methods. Stereological observations showed that the mean ovarian total volume of the DESL group (0.28 +/- 0.07cm3) was lower than that of the CON group (1.55 +/- 0.23cm3) (p<0.001). On the other hand, the total number of pre-antral follicles in the ovaries of DESL (555.32 +/- 151.47) females were significantly lower than the control group (1162.96 +/- 189.19) (p<0.001). In the DESL group, the mean volumes of epithelium, endometrium, myometrium and total volume of the uterus were significantly (p<0.001) lower than in the control groups. In conclusion, these findings indicate that the long-term deslorelin implant (i) interferes with the normal cyclicity of female rats and (ii) affects the pre-antral follicle population. Further studies will be required to determine the effects of long-term deslorelin treatment on the pre-antral follicle numbers and future fertility in other species.
Long-Term Effects of Deslorelin on Ovarian Preantral Follicle Number in Female Rats: Preliminary Stereological Observations
(Wiley-blackwell, 2011) Alkis, I.; Sendag, S.; Cetin, Y.; Akyol, V.; Ragbetli, C.; Wehrend, A.; Ragbetli, M.
Primary Gestational Choriocarcinoma of the Uterine Cervix and Fallopian Tube: the Diagnosis of Ectopic Pregnancy Is Not Always a Benign Condition
(Bmj Publishing Group, 2019) Karaman, E.; Kolusan, A.; Alkis, I.; Karaaslan, O.; Sahin, H. G.; Gul, A.
Relation of Maternal Blood Iron, Total Iron Binding Capacity and Ferritin Levels With Fetal Values
(Chemical Publishing Co., 2010) Imamoglu, N.; Alkis, I.; Saylik, S.; Tuna, V.; Bayram, N.; Gulkilik, A.; Demir, H.
In this study, 74 prospective mothers proposed delivery during the period of 01.11.2003-31.08.2004 in Bakirkoy Maternity and Woman's and Children's Diseases Education Hospital, Turkey were included. They were divided into two groups based on hemoglobin levels of mothers as group I (hemoglobin = 11 g/dl, n = 42) and group II (hemoglobin < 11 g/dl, n = 32). Hemoglobin (Hb), hematocrit (Htc), mean erythrocyte corpuscular volume (MCV), mean erythrocyte corpuscular hemoglobin concentration (MCHC), serum iron, total iron binding capacity (TIBC), serum ferritin levels and the percentage of transferrin saturation were determined in mothers and umbilical cord blood of their newborns. Additionally, birth weight of all babies were recorded. Mean ferritin level in umbilical cord blood was found higher than that in mother's blood. A significant correlation was found between serum ferritin levels of mothers and infants and between serum ferritin levels of babies of anemic and non-anemic mothers. No difference was found in terms of baby weight between two groups. In this study, it was concluded that iron deficiency of mother affected ferritin level of infant and that serum ferritin level should be increased in pregnant women for diminishing the risk of iron deficiency anemia in newborn infants.