Browsing by Author "Alpaslan, D."

Now showing 1 - 3 of 3

P(Thyme Oil) and P(Clove Oil) Organo-Particles With Biocompatible, Anticancer, Antioxidant, and Antibacterial Properties Against Capan-1 and L-929 Cells
(John Wiley and Sons Inc, 2024) Alpaslan, D.; Ersen Dudu, T.; Moran Bozer, B.; Aktas, N.; Turk, M.
The synthesis of p(ClO) and p(TO) organo-particles from clove oil and thyme oil is the first in the literature. The particles were tested against the L-929 cell line for cell viability/cytotoxicity. The anticancer activity was studied against the Capan-1 pancreatic cancer cell line. p(ClO) and p(TO) organo-particles were featured by thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, antimicrobial, and in vitro cytotoxicity specialties were investigated. p(ClO) and p(TO) organo-particles were found to be effective on the L-929 fibroblast cell line and Capan-1 pancreatic cancer cell line in research on Capan-1 and L-929 cell lines. Additionally, it was shown that large dosages of p(ClO) organo-particles were not hazardous to L-929 cell lines. A difference was found between the rates of cell viability and apoptosis and necrosis when the MTT study findings of p(ClO) and p(TO) organo-particles were studied in Capan-1 cell line. The p(TO) organo-particle had the highest % apoptosis rate. At the 100 g mL−1 concentration, the fibroblast cell viability of p(ClO) and p(TO) organo-particles was 176.46% and 107.78%, respectively. The IC50 value derived for the decrease in viability was determined as (2.22 mg mL−1) and it was calculated that it would kill the pancreatic cancer cells by 50% when doxorubicin and p(ClO) were administered combined. © 2023 Canadian Society for Chemical Engineering.
Quantum Size Effect of Cadmium-Doped Titanium Dioxide Photocatalysts Towards Methylene Blue Degradation and Electrooxidation
(Springer, 2022) Kivrak, H.; Saleh, D., I; Alpaslan, D.; Caglar, A.; Selcuk, K.; Dudu, T. E.; Aktas, N.
At present, titanium dioxide supported cadmium catalysts were prepared at 0.5-5% cadmium loading by impregnation method. 0.5% Cd/TiO2 catalyst was characterized with scanning electron microscopy-energy dispersive X-ray (SEM-EDX), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Characterization results revealed that by cadmium doping to titanium dioxide, surface electronic properties and crystal structure of Cd/TiO2 catalysts changed as obtained from SEM-EDX, XRD, and XPS. Following this, methylene blue degradation and electrochemical oxidation measurements were examined under UV light. Electrooxidation measurements were investigated to determine the methylene blue electrooxidation activities of titanium dioxide supported cadmium catalysts prepared at 0.5-5% cadmium loading with the cyclic voltammetry, chronoamperometry, and electrochemical impedance spectroscopy in 1 M KOH + 0.1875 M Methylene blue solution at 100 mV s(-1) in the dark and under UV light. Methylene blue oxidation measurements revealed that 0.5% Cd/TiO2 had the highest catalytic activity and stability in the dark and under UV illumination. 0.5% Cd/TiO2 electrode exhibited enhanced electrocatalytic activity under UV illumination. Photocatalytic methylene blue oxidation enhanced for 0.5% Cd/TiO2 by altering the surface electronic structure and crystal properties of titanium dioxide, assigned to structure sensitivity. As a result, this electrode production method is promising for the photocatalytic water remediation.
Synthesis and Preparation of Responsive Poly(Dimethyl Acrylamide/Gelatin and Pomegranate Extract) as a Novel Food Packaging Material
(Elsevier Ltd, 2020) Alpaslan, D.; Dudu, T.E.; Şahiner, N.; Aktaş, N.
In this study a novel and smart multi-functional hydrogel (MFH) was synthesized from N, N dimethyl acrylamide (DMAAm), gelatin, citric acid (CA) and pomegranate extract (PE) for instant and easy monitoring of the color change in MFH due to changes in medium conditions such as pH and temperature. MFH was utilized as food packaging material, equipped with the developed properties. MFH was synthesized with a redox polymerization technique in film form on petri dishes. Mechanical and water resistance properties of MFH were improved by CA and N, N, methylenebisacrylamide, while PE was used to gain antimicrobial, antioxidant and anthocyanin properties. Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analyzer (TGA), Liquid Chromatography-Mass Spectroscopy (LC-MS/MS) and Scanning Electron Microscopy (SEM) instruments were utilized for characterization of MFH. FTIR revealed the existence of bonding interactions between the functional group of PE and gelatin, carbonyl groups of DMAAm and carboxylic acid groups of CA. TGA results indicate that MFH was stable up to 400 °C. Then the response of total antioxidant and anthocyanin activities leading to the color change in MFH were studied at different pH values. The color change in MFH was monitored even at very small pH changes in the medium. Moreover, antimicrobial activity and stability of MFH were investigated when it was tested in harsh environments and against Escherichia coli, Bacillus subtilis and Staphylococcus aureus on real samples of whole pasteurized milk and cheese for a 7-day period. It exhibited remarkable antimicrobial activity with pasteurized whole milk and cheese. It was concluded that MFH is a very good candidate to be used as biodegradable food packaging material. © 2019 Elsevier B.V.