Browsing by Author "Alpaslan, Nazli Zeynep"

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Biochemical Marker Levels in Peri-Implant Crevicular\rfluid of Completely Edentulous Patients With Two\rimplant-Supported Mandibular Overdentures Before\rand 6 Months After Loading: Prospective Clinical Trial
(2021) Alkan, Eylem Ayhan; Alpaslan, Nazli Zeynep
Aim: The aim of this study was to determine the levels of biochemical\rmarkers detected in the peri-implant crevicular fluid (PICF) before and 6\rmonths after loading in completely edentulous patients with two implantsupported mandibular overdentures and to correlate them with clinical\rparameters.\rMethodology: Two implants were applied to the mandibular canine\rregion of the 20 completely edentulous and systemically healthy patients\r(11 females, 9 males) with conventional 2-stage surgery. PICF samples of\rthe participants were collected before and 6 months after prosthetic\rloading, and clinical parameters—including modified plaque index (MPI),\rgingival index (GI), bleeding on probing (BoP), probing pocket depth (PPD),\rand keratinized gingival width (KGW)—were recorded. Interleukin-1β (IL1β), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-8 (MMP-8),\rand aspartate aminotransferase (AST) levels were examined in PICF\rsamples via enzyme-linked immunosorbent assay (ELISA).\rResults: The average age of the participants was 57.05 ± 9.82 years.\rAlthough a decrease was observed in all clinical parameters after\rprosthetic loading compared to baseline levels, this decrease was not\rconsidered statistically significant (p>0.05). PICF volume showed a\rstatistically significant decrease from baseline to 6 months (p<0.05). The\rdecreases observed at 6th month values in all of the biochemical markers\rexamined were not found to be statistically significant, similar to the\rclinical parameters (p>0.05).\rConclusion: Within the limits of this study, the PICF marker levels and\rclinical parameters determined following osseointegration and 6 months\rafter prosthetic loading are similar. This suggests that the studied sample\rhas prosthetic restorations that contribute positively to the tissue\rmaturation process and apply ideal forces to the tissue. More\rcomprehensive studies are recommended to understand the tissue healing\rprocess after implant treatment.
Effect of Submucosal Dexamethasone on Postoperative Pain, Swelling and Trismus After Periodontal Surgery: a Randomized Clinical Study
(Springer Heidelberg, 2024) Altindal, Dicle; Alsafadi, Anas; Alshujaa, Basem; Talmac, Ahmet Cemil; Ege, Bilal; Calisir, Metin; Alpaslan, Nazli Zeynep
Objective The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone (DEX) on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery (PFS). Methods In this randomized controlled split-mouth study, 25 patients underwent PFS in the mandible, whereby postoperative, submucosal DEX was injected to the surgical field to the test group and submucosal normal saline was applied to the control group. Pain was evaluated using the Visual Analogue Scale (VAS) and the 101-point numeric rate scale in the first 8 h after PFS and on the 2nd, 3rd, 4th, and 7th days, whereas swelling, chewing efficiency, trismus, healing, discomfort and analgesic consumption were evaluated preoperatively on the 1st, 2nd and 7th days. Results In the intergroup evaluation, the VAS-7th hour value of the test group was lower than the control group(p < 0.05). On the 1st day, it was observed that there was less swelling and more chewing efficiency in the test group than in the control group(p < 0.05). When time-dependent changes were examined, the decrease in mouth opening due to trismus in the control group was greater than that in the test group on the 1st and the 2nd days compared to the preoperative period(p < 0.05). Finally, postoperative healing, discomfort, and analgesic consumption were similar between groups. Conclusion Within the limits of this study, the submucosal DEX may be an effective protocol in the management of pain, swelling, and trismus after PFS. Clinical relevance Our findings shed light on the possible effects of DEX after PFS. Trial registration This study was registered on ClinicalTrials.gov (NCT06119893).
Evaluation of the Effect of Er,cr:ysgg Laser Application on Peri-Implant Crevicular Fluid Receptor Activator of Nuclear Factor-Kappa B Ligand and Osteoprotegerin Levels in the Non-Surgical Treatment of Peri-Implantitis: a Randomized Clinical Trial
(Wiley, 2024) Alpaslan, Nazli Zeynep; Altindal, Dicle; Akbal, Damla; Talmac, Ahmet Cemil; Tunc, Serap Keskin; Ertugrul, Abdullah Seckin
Background: This study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non-surgical mechanical debridement (MD) on clinical parameters and peri-implant crevicular fluid receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri-implantitis. Methods: A total of 49 patients who underwent non-surgical treatment of peri-implantitis were randomly divided into two groups. The control group (n = 26) received MD alone, while the laser group (n = 23) received MD+Er,Cr:YSGG. The clinical parameters (bleeding on probing [BoP], gingival index [GI], plaque index [PI], probing depth [PD]), marginal bone loss (MBL), and biochemical parameters (RANKL and OPG) were measured at baseline (T0) and 6 months after treatment (T1). Results: There was a statistically significant decrease in all the clinical parameters in both groups at T1 compared to T0 (p < 0.05). The BoP, PD, MBL, and RANKL reductions were significantly higher in the laser group than in the control group (p = 0.046, p = 0.014, p = 0.047, p = 0.045, respectively). The OPG levels significantly increased at T1 in the laser group (p = 0.01). The OPG/RANKL ratio increased significantly in both groups at T1, which favored the laser group (p = 0.034). Conclusions: Although both treatment methods were influential in treating peri-implantitis, the laser group (MD+Er,Cr:YSGG) yielded more favorable results by reducing clinical inflammation and improving biochemical parameters. Based on these findings, Er,Cr:YSGG laser may be a beneficial adjunctive treatment in this patient group.
Evaluation of the Reliability of Color-Based Phenotype Probes in the Determination of Gingival Phenotype
(Marmara Univ, Inst Health Sciences, 2024) Alpaslan, Nazli Zeynep; Sari, Elif Töre
Objective: This study aimed to determine gingival thickness with newly developed color-based phenotype probes and to compare the results with the traditional method (transgingival probing). Methods: 100 individuals with a mean age of 38.37 ± 11.03 years who had Miller I class gingival recession in the anterior region were included in the study. In measurements performed with color-based phenotype probes, white (thin), green (medium), and blue (thick) colored tips were used. In the transgingival probing method, a digital caliper with a penetration depth of 0.01 mm sensitivity was used. Results: Of the teeth included in the analysis, 45% were in the maxillary anterior region, and 55% were in the mandibular anterior region. The mean tissue thickness was 0.76 ± 0.17 mm in the mandibular jaw and 1.22 ± 0.36 mm in the maxillary jaw (p= .001). A statistically significant relationship was found between the values determined with the transgingival method and the observed probe color (p= .001). The tissue thickness values of the cases whose observed probe color was white were significantly lower compared to those with green, blue, and no color (p< .05). When the mean tissue thicknesses were compared according to colors, tissue thickness significantly increased toward the blue color (p= .001). There was a statistically significant relationship with the gingival thickness measurement values (p= .001), and a low level of agreement was determined (Kappa=0.159). In addition, it was determined that different colors were observed with the color-based phenotype probes in the same quantitative ranges. Conclusion: Based on the assumption that color-based phenotype probes yield more subjective results, we believe that they can be used in clinical practice to determine gingival phenotype, but when quantitative data are required, prefering to use the transgingival method woud give more accurate results.
Peri-Implant Phenotype, Calprotectin and Mmp-8 Levels in Cases Diagnosed With Peri-Implant Disease
(Springer Heidelberg, 2024) Onder, Yasemin Beliz; Alpaslan, Nazli Zeynep
Objectives The purpose of this prospective cohort study is to evaluate the effect of peri-implant phenotype (PPh) on the severity of peri-implant diseases and the results of non-surgical mechanical treatment (NSMT), along with calprotectin (CLP) and MMP-8(matrix metalloproteinase-8) levels. Materials and methods 77 implants from 39 patients were included. The implants were categorized Group-1(peri-implant mucositis), Group-2(peri-implantitis).Baseline (0. Month-PrT) clinical parameters (PD, GI, PI, BOP, CAL) and radiographic bone loss were documented, and peri-implant crevicular fluid (PICF) samples were collected. Various intruments and methodologies were employed to assess PPh components (mucosa thickness, supracrestal tissue height, keratinized mucosa) and peri-implant attached mucosa (AM). NSMT was applied to diseased implant sites. All clinical parameters were reassessed again by taking PICF samples at the 6th month-after treatment (PT). In PICF samples obtained from both groups, MMP-8 and CLP levels were evaluated using the ELISA test. Results PrT-PD,PrT-GI,PrT-CAL and PrT-BOP percentage values in Group-2 were significantly higher than Group-1.PrT-PD,PrTPI scores are significantly higher in thin biotype implants. All components of the PPh and AM were significantly lower in thin biotype. Intra-group time-dependent changes of MMP-8 and CLP were significant in both groups (p < 0.05). When the relationship between thin and thick biotype and biochemical parameters was evaluated, the change in PrT-PT didn't show a significant difference (p > 0.05). Conclusions PPh plays a role in influencing the severity of peri-implant diseases. However, the impact of phenotype on NSMT outcomes was similar in both groups.
Periodontal Sağlık ve Özgüven İlişkisinin Araştırılması
(2020) Sari, Elif Töre; Alpaslan, Nazli Zeynep
Amaç: Periodontal hastalıklar birçok kolaylaştırıcıfaktöre bağlı olarak gelişebilmektedir. En önemlisi isebireylerin oral hijyenlerindeki yetersizliktir. Periodontalhastalıkların yalnızca ağız boşluğu ile değil, sistemikdurumlar ve psikososyal özellikler ile de ilişkili olabileceğibelirtilmektedir. Bu çalışmada bireylerin periodontalsağlığı ile özgüven düzeyleri arasındaki ilişkinin çeşitliklinik parametreler açısından araştırılması amaçlanmıştır.Ayrıca bireylerin gülüş estetik indeksi (GEİ) skoru dadeğerlendirilmiş ve incelenen parametrelerleilişkilendirilmiştir.Gereç ve Yöntem: Araştırma, Periodontoloji kliniğinerutin dişeti tedavisi için başvuran, gönüllü ve yaşları 18-65 arasında değişen 126 birey üzerinde yürütülmüştür.Katılımcıların her birine, içsel özgüven ve dışsal özgüvenolmak üzere 2 alt kategoriden oluşan 33 maddelik özgüvenölçeği uygulanmıştır. Bireylerin gingival indeks, plakindeksi ve sondlanan cep derinliğini içeren rutinperiodontal parametreleri ve GEİ skoru kayıt altınaalınmıştır. Verilerin istatistiksel analizinde Tek yönlüVaryans analizi ve Ki-kare testi kullanılmıştır.Bulgular: Katılımcıların %60,3’ü 18-30 yaş aralığındaolup, %45,2’si üniversite ve/veya üzeri eğitim seviyesinesahiptir. Periodontal parametre değerleri ve özgüvenskorları arasındaki korelasyonlarda ve GEİ deg eri ileo zgu ven skorları arasında istatistiksel olarak anlamlı farktespit edilmemiştir (P > 0,05). GEİ skoru gingivitis teşhisedilenlerde, periodontitis’e oranla istatistiksel olarakanlamlı şekilde yüksektir (P = 0,005). Erkek katılımcılarındışsal özgüven skorunun kadın katılımcılara göreistatistiksel olarak anlamlı derecede yüksek olduğu tespitedilmiştir (P < 0,05).Sonuç: Bu çalışmanın sonuçları periodontal sağlığıgösteren parametreler ile özgüven skorları arasında olasıbir pozitif ilişkiyi doğrulamamıştır. Bu durumunkatılımcıların çoğunluğunun genç ve eğitim düzeyi yüksekbireylerden oluşmasına bağlı geliştiği düşünülmektedir.Örneklem büyüklüğünün artırıldığı daha kapsamlıçalışmalara ihtiyaç duyulmaktadır.
Stajyer Diş Hekimliği Öğrencileri ve Asistan Diş Hekimlerinin Edinilmiş Immün Yetmezlik Sendromu (Aids) Hakkındaki Bilgi Düzeyleri ve Tutumlarının Değerlendirilmesi
(2021) Alpaslan, Nazli Zeynep; Önder, Yasemin Beliz
Amaç: Edinilmiş immün yetmezlik sendromu (AIDS) aşısı bulunmayan ve hastaların yaşam kalitelerini olumsuz etkileyen bulaşıcı bir hastalıktır. Bu çalışmada stajyer diş hekimliği öğrencileri (grup 1) ve asistan diş hekimlerinin (grup 2) AIDS ile ilgili bilgi düzeyleri ve tutumlarının araştırılması amaçlanmıştır. Gereç ve Yöntem: Bu kesitsel çalışma için gönüllü olan katılımcılara 3 bölümden oluşan (demografik özellikler, AIDS bilgi düzeyi ve tutum) ve çoktan seçmeli soruları bulunan bir anket dağıtılmıştır. Verilerin istatistiksel analizinde Ki-kare testi kullanılmıştır. İstatistiksel anlamlılık düzeyi p<0,05 olarak kabul edilmiştir. Bulgular: Araştırmayı yaş ortalaması 24,26 (±2,52) olan 89 katılımcı (46 kadın, 43 erkek) tamamlamıştır. Gönüllüler gruplara %64 (grup 1) ve %36 (grup 2) oranında dağılmıştır. %97,8 oranında katılımcı AIDS‟in cinsel yolla bulaşan bir hastalık olduğunu belirtmiştir. Anketin ilk kısmı olan bilgi ölçeği bölümünde yalnızca „„AIDS hastasının öksürmesi hastalığı bulaştırabilir‟‟ ifadesine verilen yanıtlar iki grup arasında anlamlı şekilde farklıdır (p=0,023). Tüm tutum ölçeği sorularına verilen yanıtlarda ise, iki grup arasında istatistiksel olarak anlamlı fark tespit edilmemiştir (p>0,05). Sonuç: Bu çalışmanın sonuçları, AIDS hastalığını tanıma ve bulaş yolları açısından her iki grup için de kabul edilebilir bir farkındalığı gösterse de hastalığa bakış açısı ve tutum açısından halen önyargılar mevcuttur. Hekim ve hekim adaylarının hastalığa dair daha fazla bilgi sahibi olabilmesi için eğitici programlar planlanması gerekmektedir.