Browsing by Author "Altinli, Ediz"

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Effect of Pentoxifylline and Vinpocetine on the Healing of Ischemic Colon Anastomosis: an Experimental Study
(Turkish Assoc Trauma Emergency Surgery, 2011) Sumer, Aziz; Altinli, Ediz; Senger, Serkan; Koksal, Neset; Onur, Ender; Eroglu, Ersan; Gunes, Pembegul
BACKGROUND In the current study, we aimed to investigate the influences of pentoxifylline, which increases the flexibility, deformability and viscosity of the erythrocytes while reducing the aggregation abilities of the platelets, and vinpocetine, which has neuroprotective and antioxidant effects, on healing of colonic anastomoses. METHODS We used 30 Albino Wistar rats. Subjects were divided into three groups of 10 rats each. Colonic ischemia was established in all the groups. Following colonic transection, anastomosis was performed. Group A received intraperitoneal saline, whereas Group B and Group C received pentoxifylline and vinpocetine, respectively. The subjects were sacrificed on the postoperative 5th day by ether anesthesia, and their colonic bursting pressures were measured. The anastomotic area was excised for hydroxyproline assay and histopathologic examination. RESULTS According to intergroup comparisons, colonic bursting pressure was found to be higher in the treatment groups than in the control group; however, the difference was not statistically significant. Intergroup comparisons regarding tissue hydroxyproline levels showed statistically significant differences between Groups A and B, Groups A and C and Groups B and C. CONCLUSION Similar to pentoxifylline, vinpocetine was also shown to have a beneficial effect over ischemic colon anastomoses.
Epcam Is a New Potential Serum Biomarker for Early Gastric Cancer
(Bayrakol Medical Publisher, 2023) Eroglu, Ersan; Kiziltan, Remzi; Algul, Sermin; Kemik, Ozgur; Altinli, Ediz
Aim: Overexpression of epithelial cell adhesion molecule (EpCAM) has been shown in a wide spectrum of epithelial cancers. In this study we aimed to examine the utility of serum EpCAM levels as a new marker for early diagnosis of gastric cancer, and to determine its association with different stages of gastric cancer. Material and Methods: A total of 88 patients who underwent resection due to gastric cancer and 44 healthy subjects as the control group were included in the study. The diagnosis of gastric cancer was confirmed by a combination of upper gastrointestinal endoscopy, endoscopic ultrasonography, and histopathology. EpCAM levels were evaluated using the enzyme-linked immunosorbent assay (ELISA) method following the instructions of the manufacturer. Results: The mean preoperative EpCAM level was found as 235.7 +/- 34.2 pg/mL in the patient group and 42.5 +/- 2.38 pg/mL in the control group. The mean preoperative serum EpCAM level was found to be significantly higher in gastric cancer patients compared to the control group (p<0.001). In addition, mean EpCAM levels were higher in patients with class T4 and T2 compared to T1. Mean EpCAM levels were also significantly higher in N1 and N2 classes compared to N0, and in M1 compared to M0 (all, p<0.001). Discussion: The results of this study indicate that the elevated expression of the EpCAM levels can predispose to the development of gastric cancer. Thus, the analysis of this marker could be a useful biomarker for screening patients with gastric cancer.
Prevention of Adhesion To Prosthetic Mesh: Comparison of Oxidized Generated Cellulose, Polyethylene Glycol and Hylan G-F 20
(Turkish Assoc Trauma Emergency Surgery, 2011) Altinli, Ediz; Sumer, Aziz; Koksal, Neset; Onur, Ender; Senger, Serkan; Eroglu, Ersan; Gumrukcu, Gulistan
BACKGROUND The aim of this study was to investigate the impact of oxidized generated cellulose, polyethylene glycol and hylan G-F 20 on adhesion formation, fibrosis and inflammation after repair of abdominal wall defect with polypropylene mesh in an animal model. METHODS Forty rats were divided into four groups and abdominal wall defect was established. The defect as repaired with polypropylene mesh alone (control group), polypropylene mesh and hylan G-F 20 as adhesion barrier, polypropylene mesh and oxidized generated cellulose as adhesion barrier, or polypropylene mesh and polyethylene glycol as adhesion barrier in Groups I, II, III, and IV, respectively. Rats were sacrificed on the 14th day in all groups. RESULTS A comparison of the groups in terms of macroscopic adhesion scores revealed statistically significant differences between the groups using an adhesion barrier and the control group. Severe fibroblast proliferation was seen in the control group and mild fibroblast proliferation was seen in polyethylene glycol group. CONCLUSION Polyethylene glycol is an effective adhesion prevention barrier. Laparoscopic surgery has become the standard method in most of the surgical field. With its laparoscopic apparatus, polyethylene glycol allows easy application on the damaged surface.
Primary Intraperitoneal Pelvic Hydatid Cyst Rupture: Case Report
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2011) Sumer, Aziz; Caglayan, Kasim; Celik, Atilla; Altinli, Ediz; Koksal, Neset
Hydatid disease is an endemic disease in Turkey. It is located mostly in the liver. Primary peritoneal hydatid cyst is rare and the mechanism of this infection is unknown. Ultrasonography and computerized tomography are the main diagnostic tools in identifying hydatid cyst. Surgical treatment is mandatory. In this article we report a case of primary intraperitoneal pelvic cyst hydatid rupture in a 25 years old male who admitted to the emergency department with a history of abdominal pain. At operation, ruptured pelvic hydatid cyst was found and excised. Partial omentectomy was applied. Peritoeal cavity was lavaged with hypertonic saline solution. Medical theraphy with albendazole was started. The postoperative course of the patient was uneventful. In endemic regions, hidatid cyst should be thought in differential diagnosis of pelvic cyst.