Browsing by Author "Altinoz, Orhan"

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Comparison of the Efficacy of Cis-Platin - Gemcitabine Combination With Cis-Platin - Etoposide in Advanced and Locally Advanced Nonsmall Cell Lung Cancer
(Bilimsel Tip Publishing House, 2007) Ozbay, Bulent; Altinoz, Orhan; Islek, Ayten; Sertogullarindan, Bunyamin
In this study, we aimed to compare the efficay and toxicity of cis-platin - gemcitabine (PG) combination with cis-platin - etoposide (PE) in advanced and locally advanced nonsmall cell lung cancer. PG treatments were given to 18 patients (2 females, 16 males) and PE to 17 patients (5 females, 12 males), totally 35 patients stage III b or IV. Combination chemotherapies of cis-platin at a dose of 80 mg/m(2) on day 1, gemcitabine 1250 mg/m2 on day 1 and 8, and etoposide 100 mg/m(2) 1st, 2nd, and 3rd days, were administered. Overall response rates were found 33.3% and 41.1% in PG and PE, respectively (p > 0.01). Median survival was 5 months in both groups. One year survival was found to be 16.6% in PG group and 17.6% in PE group. Nausea and vomiting were the most frequent side effects of PE group in a rate of 64.7% (in 11 cases) followed by anemia 38.8% (in 7 cases) in PG group, and nefrotoxicity 5.8% (in one case) in PE group. As a result although we have found partial response advantage for PE combination, but not statistically significant, there was no median or one year survival advantage between both groups.
Evaluation of Tuberculosis Cases Detected in Our Region Between 1999 and 2003
(Turkish Assoc Tuberculosis & Thorax, 2008) Ozbay, Bulent; Sezgi, Cengizhan; Altinoz, Orhan; Sertogullarindan, Bunyamin; Tokgoz, Necla
This study investigates the extent of tuberculosis, its clinical features, the specification of the patients with tuberculosis, and evaluates diagnosis, treatment and their effectiveness in our region. The records of 645 patients admitted to the Tuberculosis Control Dispensary in our between January 1999 and December 2003 were evaluated retrospectively. The incidence of the disease was 0.012% and it was more common among young men and diagnosed mostly by individual examination. Twenty-six percent of the patients had a history of physical contact with a tuberculosis patient. The pulmonary and extra pulmonary involvement of the disease was 51.8% and 48.2%, respectively. Bacteriologic examination of the patients was as follows; 42.2% did not have a bacteriologic examination, 21.7% was smear and culture positive, 26.8% was smear and culture negative, and 8.7% was smear negative and culture positive. Diagnosis of tuberculosis by bacteriologic examination increased from 39.7% to 73.6% within years. Cure rates of the disease were between 12.5% and 34.4%. Completion rates of tuberculosis therapy were between 53.5% and 72.6% and treatment success rates were between 82% and 95% whereas mortality rates varied between 1.7% and 2.8%. In conclusion, we observed that new cases and smear positive cases of tuberculosis were more common among the young and among the people with low socioeconomic status, bacteriologic examination increased over time and the rate of successful treatment was high but the cure rate was low.
Influenza-Associated Pneumonia in a Turkish Area With Endemic Avian Influenza
(Wiley, 2008) Ozbay, Buelent; Sertogullarindan, Bunyamin; Tekin, Murat; Altinoz, Orhan
Background and objective: The aim of the study was to describe the effects of influenza associated with community-acquired pneumonia (CAP) on the outcome of patients in an area characterized by endemic avian influenza. Methods: Sixty patients diagnosed with CAP and requiring hospitalization were studied for the presence of influenza. Based on the presence or absence of influenza, patients were divided into two groups: group 1 were CAP patients positive for influenza and group 2 included CAP patients negative for influenza. Laboratory investigations, CXR findings and prognosis were compared. Results: Nasopharyngeal swabs or deep tracheal aspirates were tested for viral aetiology, and seven patients were positive for influenza AH3; one was positive for influenza AH1; seven were positive for influenza B; and one was positive for parainfluenza. Group 1 patients (n = 16) had a mean age of 56 years and group 2 patients (n = 45) had a mean age of 55 years. Significant increases in creatinine kinase and lymphopaenia were seen in group 1 patients. On CXR, interstitial infiltration was more marked in group 1. There was significantly higher mortality in group 1 than in group 2. Conclusion: CAP associated with influenza had a different clinical picture and outcome compared with patients without evidence of influenza.