Browsing by Author "Anil, Baris"

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Microwave-Assisted Synthesis of New Dihydropyrimidine Derivatives and Mechanism of the Reactions
(Bentham Science Publ Ltd, 2013) Akbas, Esvet; Sahin, Ertan; Yildiz, Ela; Anil, Baris; Akyazi, Inci
5-benzoyl-4-aryl-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidines were synthesized via Biginelli cyclocondensation reaction. The diethyl 2-(4-aryl-5-benzoyl-6-phenyl-3,4-dihydropyrimidin-2(1H)-ylidene) malonates were prepared by the reaction of thioxopyrimidines with diethyl 2-bromomalonate in dioxane/pyridine (10/1 v:v) under microwave irradiation and conventional conditions. The reaction of diethyl 2-(5-benzoyl-4,6-phenyl-3,4-dihydropyrimidin-2(1H)ylidene) malonate with hydrazine hydrate and urea yielded the compounds of (E)-ethyl 2-(5-benzoyl-4,6-diphenyl-3,4-dihydropyrimidin-2(1H)-ylidene)-3-hydrazinyl-3-oxopropanoate and (E)-ethyl 2-(5-benzoyl-4,6-diphenyl-3,4dihydropyrimidin-2(1H)-ylidene)-3-oxo-3-ureidopropanoate, respectively. All of these new derivatives were characterized by analytical and spectroscopic studies. The structure of the diethyl 2-(5-benzoyl-4,6-diphenyl-3,4-dihydropyrimidin-2(1H)-lidene) malonate was identified by a single crystal X-ray diffraction analysis, and the reaction mechanism was also discussed.
Microwave-Assisted Synthesis of Tetrahydropyrimidines Via Multicomponent Reactions and Evaluation of Biological Activities
(Bentham Science Publ Ltd, 2011) Akbas, Esvet; Berber, Ismet; Akyazi, Inci; Anil, Baris; Yildiz, Ela
Various pyrimidine derivatives (1a-c) were synthesized using the Biginelli three component cyclocondensation reactions of a beta-diketone, arylaldehyde, and thiourea, under microwave irradiation and conventional conditions. The acetylation of compound 1a gave 3-acetyl thioxopyrimidin 2. Also, thiazolopyrimidine (3) and (4) derivatives were obtained by a simple one-pot condensation reaction of starting compounds 1a, and 1b with 2-bromopropionic acid. The prepared compounds were screened for their antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using micro dilution procedure. The results of the study showed that the compound 4 was effective and selective for antimicrobial activity against the tested bacteria and fungi. Thus, we suggested that the compound 4 might be a new potential antimicrobial substance for bacteria and fungi.
Preparation and Detailed Characterization of Zirconia Nanopowder Supported Rhodium (0) Nanoparticles for Hydrogen Production From the Methanolysis of Methylamine-Borane in Room Conditions
(Pergamon-elsevier Science Ltd, 2018) Kanat, Mehmet; Karatas, Yasar; Gulcan, Mehmet; Anil, Baris
Uniformly dispersed Rh (0) nanoparticles supported on zirconia nanopowder were synthesized by a two-step and simple ex-situ method summarized by mixing rhodium (III) chloride hydrate with zirconia (nano-ZrO2) aqueous solution in ambient conditions followed by reduction with NaBH4. The ex-situ prepared nano-ZrO2 supported Rh (0) nano-particles (Rh/nano-ZrO2) were characterized by various spectroscopic methods, including TEM, TEM-EDX, HR-TEM, P-XRD, XPS and ICP-OES. The catalytic activity of Rh (0) nano-particles is 1050 h(-1) in terms of initial turnover frequency (TOF), which is the first study in the literature to produce hydrogen by catalytic methanolysis of methylamine-borane. In addition, the catalytic methanolysis of methylamine-borane by using Rh (0) nanoparticles was carried out in different catalyst/substrate concentrations and different temperatures to reveal rate equation and kinetic parameters. Consequently, Rh (0) nanoparticles are taken into account as an encouraging catalyst for the methanolysis of methylamine-borane and for providing a more fertile hydrogen storage gain in fuel cell operations. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
A Simple One-Pot Synthesis of 1,2,3,4-Tetrahydro Derivatives
(Wiley, 2008) Akbas, Esvet; Aslanoglu, Furgan; Anil, Baris; Sener, Ahmet
5-Benzoyl-4-(substituted phenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidines (4a-d) were synthesized using the Biginelli three component cyclocondensation reaction of an appropriate beta-diketone, arylaldehyde, and thiourea in acetic acid under reflux condition in approximately 52-65% yields. The acetylation of compounds 4a-d gave 3-acetyl thioxopyrimidine derivatives 5a-d. Also, pyrimidothiazine compounds 6a-d were prepared by a simple one-pot condensation reaction of starting pyrimidine derivatives 4a-d and 3-bromopropionic acid. The structures of compounds were characterized on the basis of elemental analyses, IR,H-1 and C-13-NMR spectra.
Studies on Reactions of Pyrimidine Compounds
(Taylor & Francis Ltd, 2007) Aslanoglu, Furgan; Akbas, Esvet; Soenmez, Mehmet; Anil, Baris
The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidin (1) have been prepared via Biginelli cyclocondensation reaction in acetic acid under reflux condition in good yield (93%). Reactions of 1 and iodomethane to afford thiopyrimidine compounds 3 and 5. Also, the acetylation of compounds 1 and 3 gave 3-acetyl thioxopyrimidine 2 and methylthiopyrimidine 4, respectively. Thioxopyrimidine derivative 6 was synthesized from 1 and POCl3/DMF Furthermore, the starting compound 1 were cyclized with various bromo compounds to the thiazolopyrimidine 7, 8, 9 and pyrimido[2,3-b]thiazine10 derivatives, in approximately 55-78% yields. The purpose of synthesizing the thioxopyrimidine derivatives is because of the high biological activities. All of these derivatives have been characterized by analytical and spectroscopic studies and the reaction mechanism is discussed.