Browsing by Author "Anlar, O."

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Acute Motor Axonal Neuropathy Cases in Van Region
(Comenius Univ, 2011) Sayin, R.; Tombul, T.; Gulec, T. C.; Anlar, O.; Akbayram, S.; Caksen, H.
Acute motor axonal neuropathy (AMAN) is a form of Guillain Barre Syndrome (GBS) seen in summer months in Northern China to cause epidemics. This form of the disease, which is also sporadically observed in other countries, constitutes less than 5 % of GBS in Western countries. It usually develops with motor findings. No sensory findings are observed. In some of the cases, the severe impairments in tissues improve however slowly and inadequately. In the motor conduction studies of cases with AMAN, motor action potential values are lowered. On needle electromyography (EMG), motor unit potential (MUP) activity is diminished with spontaneous denervation findings. Investigations were conducted on nerve conduction of patients with GBS aged from 1 to 77 years. AMAN was detected in 25 of these patients. In our investigation, AMAN as a GBS variant was detected in 39.7 % of the patients. The conduction velocities of motor nerves were in normal ranges whereas combined muscle action potentials were significantly lower. No F response could be obtained. Although AMAN is a rare variant of GBS and shows different clinical courses, it has been brought under intense scrutiny since there is high prevalence of acute inflammatory neuropathies in our region (Tab. 1, Ref. 7). Full Text in free PDF www.bmj.sk.
Clinical and Magnetic Resonance Imaging Findings of Siblings From a Turkish Family With Mother Diagnosed as Multiple Sclerosis: Case Report
(Sage Publications Ltd, 2006) Anlar, O.; Sayin, R.; Kayan, M.; Tombul, T.; Unal, O.
Clinical Presentation and the Efficacy of Antiepileptic Therapy in the Patients With Partial and Generalized Epilepsy
(2011) Sayin, R.; Tombul, T.; Anlar, O.; Caksen, H.
Epilepsy is an abnormal recurrent disease, resulting from various disorders of central nervous system. In this study, we aimed to compare the patients in terms of therapeutic efficiency. We enrolled a total of 106 patients in the study and of them, 45 were male and 61 were female, aged between 2 to 52 years. Of these patients, 69 (65%) had partial and 37 (35%) had generalized seizures. Seventy three patients were being treated with monotherapy and 33 patients were being treated with polytherapy. The number of the patients that were taking monotherapy was higher in the pediatric group (age, 0 to 16) compared to adult group (age, above 16). In the study, we tried to express the importance of monotherapy in the pediatric patients, the higher number of the pathologies that can be detected using an imaging method in the patients with partial epilepsy compared to that of generalized epilepsy, and the most frequent occurrence of therapeutic resistance in the partial epilepsies, ©2011 Academic Journals.
Food-Borne Botulism Cases in Van Region in Eastern Turkey: Importance of Electromyography in the Diagnosis
(2003) Anlar, O.; Irmak, H.; Tombul, T.; Akdeniz, H.; Caksen, H.; Kose, D.; Ceylan, A.
Objectives: Food-borne botulism is an acute form of poisoning that results from ingestion of a toxin produced by Clostridium botulinum. Botulism toxin causes its major effect by blocking neuromuscular transmission in autonomic and motor nerve terminals. Methods: In this study, we present the features of eleven cases of food-borne botulism admitted to our hospital in 2001. All of the cases were caused by home-prepared foods; green beans. In these cases, the main symptoms and signs were generalized muscular weakness, dry mouth, dysphagia, dispnea and diplopia. Electrophysiological studies were performed on four patients. Results: Motor conduction studies showed that compound muscle action potentials were decreased with normal latencies and conduction velocities. The needle electromyography showed signs of denervation potentials like fibrillation and positive waves in four patients. Repetitive nerve stimulation with high frequency (20 Hz) induced an increment close to 100% in the amplitudes in 2 of 4 patients. Conclusion: Although toxin could not be detected in the patients, the electromyographic findings supported our diagnosis. We concluded that electromyography has an important role in diagnosis of botulism, especially in the condition that serologic tests are negative or cannot be performed.
Impaired Heart Rate Variability as a Marker of Cardiovascular Autonomic Dysfunction in Multiple Sclerosis
(Blackwell Publishing, 2004) Tombul, T.; Anlar, O.; Tuncer, M.; Huseyinoglu, N.; Eryonucu, B.
Report of a Turkish Girl With Andersen-Tawil Syndrome
(IOS Press, 2006) Çaksen, H.; Ptacek, L.; Üner, A.; Fu, Y.-H.; Erol, M.; Anlar, O.; Sami Güven, A.
The case is a 9-year-old girl with a history of syncope attacks for 6 years and recurrent paraplegia attacks for 1.5 years. She was diagnosed with epilepsy and was given valproate for the attacks, but no improvement was noted. Because of her paraplegia attacks, lasting between a few hours and 3 days, abnormal findings she was diagnosed with conversion. Her prenatal, natal and postnatal history was unremarkable, and her school performance was high. There was a close consanguinity between the parents. She had four healthy sibs. Her mother, maternal uncle and maternal grandmother had intermittent fatigue, numbness on the extremities. On physical examination, she had mild elongated face and dysmorphic changes on the hands. Muscle strength was normal on the upper extremities, but no muscle activity was noted on the lower extremities. She also had no response to touch and pain stimuli on the lower extremities. On laboratory investigation, serum electrolytes including potassium level, renal and liver function tests were normal. Glomerul filtration rate was 59 mL/min/m2. QTc interval was mild prolonged (0.45 seconds). Electromyographic examination was unremarkable. On DNA mutation analysis, no mutation of KCJN2 gene coding for Kir 2.1 protein was diagnosed. Her mother had normal serum electrolytes, but had prolonged QTc interval (0.46 seconds). Her father was completely normal for serum electrolytes and electrocardiographic examination. Unfortunately, maternal uncle and grandmother could not be examined. Based on the clinical and laboratory abnormalities she was diagnosed with Andersen-Tawil syndrome and given potassium supplementation. Her paraplegia and syncope attacks were markedly decreased after initiating potassium therapy. Now, she is in the 3rd year of follow-up. She is continued to use potassium and her paraplegia and syncope attacks noted only one attack a 2-3 months. © 2006 IOS Press. All rights reserved.