Browsing by Author "Anlar, Omer"

Now showing 1 - 4 of 4

The Association of Depression With Treatment and Disability in Multiple Sclerosis
(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri dernegi, 2012) Tanik, Nermin; Aydin, Adem; Selvi, Yavuz; Gulec, Mustafa; Anlar, Omer; Tombul, Temel
Background: To investigate the effects of disability and specific treatments on depression associated with multiple sclerosis (MS). Methods: Fifty-two patients with MS (patient group) and 48 healthy subjects (control group) participated in the study. While the Beck Depression Inventory (BDI) and the Expanded Disability Status Scale (EDSS) were administered to the patients, healthy controls filled out only the BDI. Psychiatric disorders were determined using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Result: Both groups were found to be identical in their socio-demographic properties. The mean age of onset of MS was 29.1 +/- 1.2 years. There was no difference between males and females in terms of depression. The patient group consisted of patients with: relapsing-remitting MS (71.2%), secondary-progressive MS (13.5%), progressive-relapsing MS (11.5%), and primary-progressive MS (3.8%). A 12-fold increased risk for depression was found among patients with MS. Age, attack number and illness duration did not correlate significantly with risk for development of depression in MS. However, a significant relationship was found between EDSS scores and the risk for the development of depression. Depression was detected in patients using azathioprine (100%), interferon beta-1a SC (88.8%) and in patients not receiving any treatment (78.5%). Conclusion: This study indicates that, disability is an important risk factor for the development of depression, irrespective of the treatment modality. (Archives of Neuropsychiatry 2012; 49: 300-303)
Guillain-Barre Syndrome Following Bee Sting
(Georg Thieme verlag Kg, 2005) Yilmaz, Cahide; Caksen, Huseyin; Anlar, Omer; Odabas, Dursun
Peripheral Blood Monocytes in Multiple Sclerosis Exacerbations
(Professional Medical Publications, 2011) Tombul, Temet; Anlar, Omer; Akdeniz, Hayrettin
Objectives: Monocytes (MO), macrophages, and microglia have a central role in the central nervous system inflammation of multiple sclerosis (MS). During clinical activity in MS, MO activation markers increase and some interleukins and tumor necrosis factor-alpha levels are elevated. Our aim was to determine levels of absolute MO count and percentage in peripheral blood of MS patients during the attacks. Methodology: We assessed the percentage of MO by examining the blood smears in 28 patients with definite MS, in 20 patients with acute cerebrovascular disease (CVD) and in 20 healthy control subjects. Results: The mean value of absolute MO count in MS patients, CVD and control groups were as 606.67 +/- 170.52, 746.50 +/- 414.76 and 360.00 +/- 109.54 respectively. The mean values of MO percentage in MS patients, CVD and control group were 8.34 +/- 2.61%, 5.56 +/- 2.48% and 5.36 +/- 1.50% respectively. The mean percentage of MO was significantly elevated in MS patients compared with the both groups of CVD and control (P < 0.001). Conclusion: Our results suggest a possible role of an increase in MO activation in the acute exacerbations of Multiple Sclerosis.
Protective Effect of Sildenafil (Viagra) in Transient Spinal Cord Ischemia
(Karger, 2008) Kiymaz, Nejmi; Yilmaz, Nebi; Mumcu, Cigdem; Anlar, Omer; Ozen, Suleyman; Kayaoglu, Cetin Refik
Prospective study of the neuroprotective activity of sildenafil in a rat spinal ischemia model. The present study involved 21 male Sprague-Dawley rats. The animals were divided into 3 groups. Physiological serum was administered intraperitoneally to the 8 rats in the control group at the beginning of reperfusion for a period of 20 min after abdominal aortal occlusion. Sildenafil (Viagra((R))) was administered as a single 10mg/kg/day intraperitoneal dose to the 8 rats in the sildenafil group at the beginning of reperfusion after 20 min of abdominal aortal occlusion. No occlusion was performed and no agent was administered to the 5 rats in the sham group, but the abdominal aorta was reached by means of surgical intervention. Before the animals were sacrificed, several physiological and biochemical parameters were investigated, preoperative and postoperative motor functions were also assessed, and somatosensory evoked potential (SEP) monitoring and histopathological examinations were carried out. No differences were found between the physiological and biochemical parameters in each of the 3 groups. Neurological scoring performed after reperfusion demonstrated a significant improvement in the neurological results relative to those of the control group over 48 h in subjects that received sildenafil. These animals also showed better 24-hour SEP results, measured in terms of extended latency and decreased amplitude, than the control animals. A histopathological study showed reduced ischemic symptoms in rats that received sildenafil compared with those in the control group. However, no anomalies were observed in the sham group with respect to the histopathological and neurological findings. These results indicate that neurological damage due to spinal-cord ischemia-reperfusion injury can be reduced by sildenafil.