Browsing by Author "Arabaci, Ozkan"

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Cranial Aperture of the Optic Canal in Chiari Malformation Type 2: A Morphometric Study on CT Images
(Turkish Neurosurgical Soc, 2025) Erdem, Mehmet Zeki; Karaaslanli, Abdulmutalip; Yalinkilic, Abdulaziz; Arabaci, Ozkan; Akdemir, Zulkuf; Beger, Burhan; Beger, Orhan
AIM: To identify morphological differences in the cranial aperture (CA) of the optic canal (OC) in patients with Chiari malformation type 2 (CMT2) by comparing them with healthy individuals. MATERIAL and METHODS: Computed tomography images were analyzed for 40 patients with CMT2 (16 females, 24 males; mean age, 10.05 +/- 4.51 years; age range, 6-18 years) and 40 control subjects (21 females, 19 males; mean age, 10.03 +/- 4.81 years; age range, 6-18 years). Measurements included the height (HCA), width (WCA), and surface area (ACA) of the CA, as well as the distances from the CA to the anterior border of the anterior cranial fossa (AB-CA), lateral border (LB-CA), and midsagittal line (MSL-CA). Additionally, the angles of the OC were assessed in both the axial (APA) and sagittal planes (SPA). RESULTS: In the CMT2 group, mean values were as follows: HCA 3.64 +/- 0.81 mm, WCA 3.08 +/- 0.87 mm, ACA 7.58 +/- 2.84 mm2, AB-CA 44.99 +/- 7.69 mm, LB-CA 29.17 +/- 5.03 mm, MSL-CA 7.07 +/- 2.44 mm, APA 30.64 degrees +/- 6.03 degrees, and SPA 24.31 degrees +/- 5.09 degrees. In the control group, corresponding values were HCA 4.22 +/- 0.60 mm, WCA 4.54 +/- 1.04 mm, ACA 12.81 +/- 3.80 mm2, AB-CA 52.73 +/- 6.71 mm, LB-CA 35.86 +/- 4.33 mm, MSL-CA 10.21 +/- 2.21 mm, APA 35.96 degrees +/- 3.23 degrees, and SPA 28.64 degrees +/- 4.34 degrees. All measurements were significantly smaller in the CMT2 group compared to controls (p<0.001). CONCLUSION: Patients with CMT2 exhibit significantly reduced CA dimensions and angular measurements of the OC. These differences, particularly in depth and orientation, may be clinically relevant when planning surgical interventions such as OC decompression.
Efficacy of Local Dexamethasone Used in Operation Area After Lumbar Microdiscectomy on Postoperative Infection
(Professional Medical Publications, 2025) Yucel, Murat; Cetin, Eyup; Arabaci, Ozkan; Akyol, Mehmet Edip
Background & Objective: Postoperative wound infection, although relatively uncommon, remains a significant complication of spinal surgery. Preventive strategies must therefore be rigorously implemented before, during and after surgery. While local steroid administration is frequently employed during lumbar microdiscectomy to reduce neural edema, limited evidence exists regarding its effects on infection rates. This study aimed to evaluate the impact of locally applied dexamethasone in the surgical site on the incidence of postoperative infection. Methodology: This retrospective observational study was conducted between January 2020 to December 2022 at the Neurosurgery Departments of Van Y & uuml;z & uuml;nc & uuml; Y & imath;l University Medical School. A total of 200 patients (89 females, 111 males) who underwent lumbar microdiscectomy were included. Patients were divided into two groups: those who received local dexamethasone (8 mg) applied to the surgical site (n = 54) and those who did not (n = 146). No systemic steroids were used in either group. Results: In the dexamethasone group, no patients developed superficial wound infection, whereas 11 patients in the non-dexamethasone group did. No deep infection was observed in either group. Although the reduction in infection was not statistically significant, the local infection rate was significantly higher in the non-dexamethasone group (p < 0.05). Conclusion: Local administration of dexamethasone following lumbar microdiscectomy was associated with a lower rate of superficial wound infection compared with no dexamethasone use. Postoperative infection remains an important clinical concern in spinal surgery, and careful attention to perioperative preventive measures is warranted.
Histopathological and Immunohistochemical Investigation of the Effect of Shilajit in Rats With Experimental Spinal Cord Injury
(Turkish Assoc Trauma Emergency Surgery, 2023) Cetin, Eyup; Sancak, Tunahan; Keles, Omer Faruk; Unlu, Ilker; Akyol, Mehmet Edip; Arabaci, Ozkan
BACKGROUND: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI). METHODS: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. High-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 250 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. Thin sections taken from the spinal cord after euthanasia were sent for histopathological and immunohistochemical examination. RESULTS: Histopathological examination of the high-dose group showed lower amounts of morphological findings compared to the low-dose group and control group. While a significant CD68 immune reaction was observed in the control group of rats with spinal injury, the positive immune reaction was found to be significantly decreased in the Shilajit-applied groups. CONCLUSION: It is thought that the use of Shilajit in SCI will reduce the effects of secondary damage in SCI and that its administration to such patients will have positive effects on the results.
Serum Prolidase and Ischemia-Modified Albumin Levels in Neural Tube Defects: a Comparative Study of Myelomeningocele, Meningocele, and Myeloschisis
(int Scientific information, inc, 2025) Zengin, Irfan; Akyol, Mehmet Edip; Arslan, Mustafa; Arabaci, Ozkan; Yurekturk, Eyyup; Cetin, Eyup; Demir, Halit
Background: Neural tube defects (NTDs) are congenital malformations resulting from incomplete neural tube closure, leading to severe neurological impairments. Despite advances in prenatal screening and surgical interventions, the biochemical mechanisms underlying NTDs remain unclear. Prolidase, an enzyme involved in collagen metabolism, and ischemia-modified albumin (IMA), a marker of oxidative stress, may play roles in NTD pathogenesis. This study aimed to compare serum prolidase and IMA levels in infants with NTDs and healthy controls to assess their potential contribution to NTD development. Material/Methods: A case-control study was conducted, including 45 infants diagnosed with NTDs (myelomeningocele, meningocele, and myeloschisis) and 45 age-and sex-matched healthy controls. Serum prolidase and IMA levels were measured using validated spectrophotometric methods. Statistical analyses were performed to compare biomarker levels between groups and among NTD subtypes. Results: Serum prolidase levels were significantly elevated in NTD patients (2.21 +/- 0.06 IU/L) compared to controls (1.07 +/- 0.04 IU/L, p<0.001). Similarly, serum IMA levels were higher in NTD patients (0.40 +/- 0.01 ABSU) than in controls (0.22 +/- 0.01 ABSU, p<0.001). No significant differences were observed in biomarker levels among the different NTD subtypes (p>0.05). Conclusions: Elevated prolidase and IMA levels in NTD patients suggest a potential role in NTD pathogenesis, possibly through impaired collagen metabolism and oxidative stress. Further research is needed to explore their diagnostic and therapeutic implications in neural tube defect management.